A method of controlling a blood analyzer for measuring platelets is provided. The method comprises: determining a relationship between at least one first measurement value obtained by detecting platelets in at least one previous test by an electrical type detector of the blood analyzer and at least one second measurement value obtained by detecting the platelets in the at least one previous test by an optical type detector of the blood analyzer, and controlling the blood analyzer to prepare the first and/or second measurement sample for a current test according to the determined relationship.

The present invention comprises methods and systems that use acoustic radiation pressure.

The present invention comprises methods and systems that use acoustic radiation pressure.

A device for biological material detection includes a substrate; a through-hole through which a biological material to be tested passes, the through-hole being formed in the substrate; a molecule that interacts with the biological material to be tested passing through, the molecule being formed in the through-hole; a first chamber member that forms, with at least the surface including the through-hole on one surface side of the substrate, a first chamber to be filled with electrolyte; and a second chamber member that forms, with at least the surface including the through-hole on the other surface side of the substrate, a second chamber to be filled with electrolyte. The biological material to be tested is identified by the waveform of the ion current (passage time, shape, etc.) when the biological material to be tested passes through the through-hole.

Provided herein are multiplexible particle systems and related methods of making and using the multiplexible particle systems. A plurality of monodisperse polymer particle populations are provided, wherein each population has a unique electrical parameter for multiplexed detection by flow through a spatially confined electric field, and the distribution of the electrical parameter within each population is sufficiently narrow for reliable multiplex detection. The density difference between populations may be relatively uniform, such as within 30%, including within 30% of a suspending solution density for when the particles are flowed through a confined electric field and detected in a multiplex manner by a change in the electric parameter measured by a counting device. Relatively uniform density of particles is important for ensuring minimal settling while the plurality of particle populations flow together under a single flow regime. The multiplexible particle systems are used in applications including multiplex detection or quantification, electrically barcoding, sorting, and counting.

The present disclosure provides, inter alia, a device for capturing and unfolding a polymeric species (e.g., a misfolded protein) or disrupting aggregates of a polymeric species, the device including: a thin support and a plurality of nanopore structures piercing through the support, each nanopore structure having an inner surface and a void running the length of the structure, an outer boundary of the void being defined by the inner surface of the nanopore structure, the inner surface comprising hydrophobic regions capable of capturing and facilitating the unfolding of the misfolded polymeric species. Also provided are methods of separating and unfolding polymeric species, methods of treatment using these devices, and systems for measuring biomolecule transport, disaggregation and refolding in a liquid sample.

The present disclosure provides, inter alia, a device for capturing and unfolding a polymeric species (e.g., a misfolded protein) or disrupting aggregates of a polymeric species, the device including: a thin support and a plurality of nanopore structures piercing through the support, each nanopore structure having an inner surface and a void running the length of the structure, an outer boundary of the void being defined by the inner surface of the nanopore structure, the inner surface comprising hydrophobic regions capable of capturing and facilitating the unfolding of the misfolded polymeric species. Also provided are methods of separating and unfolding polymeric species, methods of treatment using these devices, and systems for measuring biomolecule transport, disaggregation and refolding in a liquid sample.

A blood analyzing method for detecting a short sample of blood in a suction tube, when blood is sucked by the suction tube constituting a blood analyzing apparatus, includes measuring a first blood parameter by using blood that is present in a first area of a blood analysis area, blood in the blood analysis area being used to analyze the blood in the suction tube, measuring a second blood parameter by using blood that is present in a second area of the blood analysis area, the second area being different from the first area, and detecting the short sample of blood based on the first blood parameter and the second blood parameter.

A blood analyzing method for detecting a short sample of blood in a suction tube, when blood is sucked by the suction tube constituting a blood analyzing apparatus, includes measuring a first blood parameter by using blood that is present in a first area of a blood analysis area, blood in the blood analysis area being used to analyze the blood in the suction tube, measuring a second blood parameter by using blood that is present in a second area of the blood analysis area, the second area being different from the first area, and detecting the short sample of blood based on the first blood parameter and the second blood parameter.

A connector for providing both a fluidic and electrical connection is disclosed, said connector having a proximal end, a distal end and an elongated body in between, characterized in that the elongated body has an inner cavity spanning throughout its length, and the distal end comprises: a) an inner body portion comprising a first inner electrical contact and b) an outer body portion comprising a second outer electrical contact having a spring element. The connector is easily adaptable to many kind of fluidic actuators and particularly to pipette instruments usually found in laboratory practice and developed to adapt fluidic actuators and pipette installments to work according to the Coulter principle in every working condition, in particular to adapt the electrical and fluidic connection between a sensing tip and an instrumented pipette.