An object identification method capable of quickly and accurately identifying a virus or the like is provided. An object identification method according to an aspect of the present disclosure includes feeding an object dispersed in a solvent to a micro-channel, and applying an AC (Alternating Current) voltage to a measurement electrode provided at the micro-channel and measuring an AC characteristic of the object when the object passes through the micro-channel. Then, a combined impedance and a phase are determined by using the measured AC characteristic, and the object is identified by using the determined combined impedance and the phase.

The invention relates to a method for imaging a body fluid sample for visual measurements relating to leukocytes, which comprises: —obtaining a measured concentration (WIC) of leukocytes in the sample; —diluting (330) a test solution obtained from the sample, with a dilution ratio (D) determined in accordance with the measured concentration of leukocytes in the sample, so as to obtain an optimum concentration of leukocytes; —rotating (400) the optical chamber containing the test solution by a centrifugation unit, so as to align the leukocytes of the test solution on an optical plane, wherein the optimum concentration of leukocytes for the test solution corresponds to a target surface density of between 20 and 1000 leukocytes per square millimetre on the optical plane; and —imaging (500) the test solution.

Described herein are cartridges and devices for operating said cartridges for analyzing a biological sample, such as a blood or saliva sample. Also described herein is an impedance sensor for analyzing a biological sample. Further described herein are methods of determining a cell count or detecting an analyte in a biological sample, which can include transporting the biological sample through a sensor comprising a channel or pore; applying an electrical current or voltage to the channel or pore; detecting an impedance within the channel or pore; and determining a cell count or detecting the analyte based on the detected impedance. Also described herein is an electrowetting electrode array that is configured to transport aqueous solutions using low voltage, such as about 50 volts or less. Further described herein are methods of transporting an aqueous liquid using electrowetting electrodes.

A method of forming a nanopore in a lipid bilayer is disclosed. A nanopore forming solution is deposited over a lipid bilayer. The nanopore forming solution has a concentration level and a corresponding activity level of pore molecules such that nanopores are substantially not formed un-stimulated in the lipid bilayer. Formation of a nanopore in the lipid bilayer is initiated by applying an agitation stimulus level to the lipid bilayer. In some embodiments, the concentration level and the corresponding activity level of pore molecules are at levels such that less than 30 percent of a plurality of available lipid bilayers have nanopores formed un-stimulated therein.

A method of forming a nanopore in a lipid bilayer is disclosed. A nanopore forming solution is deposited over a lipid bilayer. The nanopore forming solution has a concentration level and a corresponding activity level of pore molecules such that nanopores are substantially not formed un-stimulated in the lipid bilayer. Formation of a nanopore in the lipid bilayer is initiated by applying an agitation stimulus level to the lipid bilayer. In some embodiments, the concentration level and the corresponding activity level of pore molecules are at levels such that less than 30 percent of a plurality of available lipid bilayers have nanopores formed un-stimulated therein.

The present invention comprises methods and systems that use acoustic radiation pressure.

The present invention comprises methods and systems that use acoustic radiation pressure.

A modular analytic system includes a base, at least one fluid sample processing module configured to be removably attached to the base, at least one fluid sample analysis module configured to be removably attached to the base, a fluid actuation module positioned on the base, a fluidic network comprising multiple fluidic channels, in which the fluid actuation module is arranged to control transport of a fluid sample between the at least one sample processing module and the at least one sample analysis module through the fluidic network, and an electronic processor, in which the electronic processor is configured to control operation of the fluid actuation module and receive measurement data from the at least one fluid sample analysis module.

A nanopore device measures a current signal Is that flows through the nanopore device, which has an aperture and an electrode pair. A transimpedance amplifier converts the current signal Is into a voltage signal Vs. A voltage source is configured to apply a DC bias voltage Vb across the electrode pair in a normal measurement mode, and to apply a calibration voltage Vcal across the electrode pair in a calibration mode. In the calibration mode, at least one circuit constant of a measurement apparatus is calibrated based on the output signal Vs of the transimpedance amplifier and the calibration voltage Vcal.

Various embodiments herein disclose a device, comprising one or more fluid interfacing components and a cartridge holder, wherein the one or more fluid interfacing components are fixed while the cartridge holder moves along a linear guide. Also disclosed herein are methods of using the device to analyze a sample containing particles, and methods of diagnosing a disease in a subject by using the device.