An airborne particle-measuring device quantifies and qualifies contaminants of an air environment in clean-rooms, open spaces, and enclosed spaces such as homes, offices, industrial environments, airplanes in flight, cars and others. The device may include a sensor system, an electronics system, communications and information storage. The sensor system may include a high-power low-wavelength single-frequency continuous laser, an open-cavity high-efficiency mirror having an optical surface tuned to the laser frequency and a flow system that includes a vacuum pump to sample the air. The electronics system may be mounted on a single multilayer PC board with a microprocessor, firmware, electronics and a touch-screen LCD display. Innovations in light source, flow control, analog and digital signal processing, components integration and software allow provision of equipment in a wide range of high-complexity settings that require precise particle measurements.

A system for detecting microbial cells in a sample includes an apparatus configured to image at least one cell in the sample, and a cooling device. The apparatus includes a holder having an internal portion and an external portion which are configured so as to secure a membrane between the portions, and an imaging device disposed above the external portion and configured to permit examination of the at least one cell. The apparatus further includes a stage attachable to a stage platform configured to connect to a motor, and a projecting member projecting from an upper surface of the stage and configured to receive and exchange solution. The cooling device includes a thermoelectric cooling element and/or at least one tube configured to circulate a cooling medium beneath the stage so as to cool the sample.

There is provided a droplet sorting device including a detector configured to detect a state of droplets ejected from an orifice that generates a fluid stream and of satellite droplets existing between the droplets, and a controller configured to control a frequency of a driving voltage supplied to a vibration element that applies vibration to the orifice on the basis of positions where the satellite droplets exist.

An apparatus (10) for characterizing particles, comprising: a microscope objective with an optical axis and a depth of field; a holder cell (22) configured to position the particles in a generally planar volume below the microscope objective, the planar volume being substantially normal to the optical axis and having a depth that is less than or equal to the depth of field, wherein a portion of the cell holder (22) for positioning in the optical axis of the microscope objective is substantially free of significant spectral features in a Raman spectral range; an x-y stage (20) to move the microscope objective relative to the holder cell (22) in x and y directions to align particles with the optical axis of the microscope objective while the particles are held by the holder cell (22), a detector (18) for acquiring an image of a particle through the microscope objective, a laser operable to illuminate a particle held by the holder cell (22), a Raman spectrometer (16) arranged to obtain a spectrum including the Raman spectral range from the illuminated particle, and characterizing logic operative to characterize the particle based on image processing operations performed on the acquired image and based on the Raman spectrum. The holder cell (22) comprises a first plate (34) and a second plate (36) that are separated by a predetermined distance defining the planar volume depth.

The invention relates to detecting cell biomarker signatures and integrated cell biomarker-morphological profiles by detecting resonance-light scattering of functionalized nanoparticles.

A device for monitoring a bioreactor is designed for in-situ analysis, e.g., by NIR. The device is configured for maintaining a sample detection region in the reactor medium and can include two or more components, at least one of which is fabricated additively. In an example, a light beam propagates along a free space optical path, passes through a thin 3D printed layer and traverses the sample detection region, where it becomes modulated or modified by interactions with analytes present in the bioreactor. The transmitted light reaches and passes through another thin 3D printed layer and is detected by a photodetector, internal to the device. The electrical signal from the photodetector can be directed to an analyzer via electrical connections. The device or a component thereof can be designed for single use applications.

A sample detecting device is used in cooperation with an image capturing device. The sample detecting device includes a first assembly and a second assembly. The first assembly includes a light emitting unit and a light-permeable unit. The light-permeable unit is disposed at one side of the light emitting unit. The first assembly and the second assembly match and connect with each other to form a sample containing space. The second assembly includes a body and a convex lens. The body has a first cavity portion and a second cavity portion. The light-permeable unit is disposed in the first cavity portion, and the convex lens is disposed in the second cavity portion. The light emitted from the light emitting unit sequentially passes through the light-permeable unit and the convex lens and leaves the body.

Methods described herein, in some embodiments, permit extraction of particle structural and/or surface charge data from gradient induced particle motion in channels. In one aspect, a method of manipulating particle motion comprises introducing a fluid into a channel, the fluid comprising particles, and driving particle accumulation to a preselected location in the channel by setting advective velocity of the fluid to offset diffusiophoretic mobility of the particles at the preselected location.

A cell observation system 1, for measuring fluorescence emitted from a cell held by a microplate 20 having a plurality of wells 21, comprises a microplate holder 11 for mounting the microplate 20, an electrical stimulator 16 arranged with a plurality of electrode pairs 17 including positive and negative electrodes 17b, 17a, a position controller 30 for controlling a position of the electrical stimulator 16 so as to place the electrode pairs 17 within the wells 21, a moving image acquisition unit 40 for detecting the fluorescence from the sample S within the wells 21, and a data analyzer 50 for setting a part of a region facing the positive electrode 17b on the well 21 as an analysis region and analyzing an optical intensity in the analysis region so as to acquire analysis information concerning the sample S.

The present disclosure relates to a device for chromatic discrimination and counting of organisms in a liquid medium with application to organisms belonging to the genus Daphnia, Ceriodaphnia, Artemia, as well Collembola; or similar organisms. The device can be applied in the field of ecotoxicology and involves technologies in the areas of analytical instrumentation, electronics, computer science and biology.