A container (1) has a measuring-cell housing (5) that protrudes into the container interior (2). The measuring-cell housing (5) has a measuring gap (6) bounded by two opposed spaced-apart lateral surfaces (8, 9), and a connecting surface (10) connects the lateral surfaces (8, 9). Each lateral surface (8, 9) has an optical window (11, 12). A first optical fiber (15, 15) is arranged before the first window (11) and a second optical fiber (17, 17) is arranged before the second window (12). Receiving channels (14, 16, 18) are arranged before the windows (11, 12, 13) and subsequently can be fit with the optical fibers (15, 15, 17, 17, 19) from the outside. The measuring-cell housing (5) having the windows (11, 12, 13) and the receiving channels (14, 16, 18) is connected fixedly to the wall (3) of the container interior (2).

An infusion set and an intravenous bag adapter constructed of ultraviolet transmissive thermoplastic are used in spectroscopic validation of pharmaceuticals. The described hardware allows for qualitative and quantitative assurance of medications and is used to prevent medication errors. The thermoplastic is transmissive in the range below 315 nanometers. In one embodiment, the invention comprises a spectrometer and a test chamber that are unaffected by the presence of ambient light. The spectrometer includes an unshielded slot or receptacle into which the test chamber is easily fitted. This embodiment can function well in drug diversion programs for which unused post-op narcotics can be tested.

A system of measuring hemoglobin and bilirubin parameters in a whole blood sample using optical absorbance. The system includes an optical-sample module, a spectrometer module, an optical fiber module optically connecting the optical-sample module to the spectrometer module, and a processor module. The optical-sample module has a light-emitting module having a LED light source, a cuvette and a calibrating-light module. The processor module receives and processes an electrical signal from the spectrometer module and transforms the electrical signal into an output signal useable for displaying and reporting hemoglobin parameter values and/or total bilirubin parameter values for the whole blood sample.

In some aspects, reader systems for optically detecting binding agents or analyte complexes in a sample as a result of performing biochemical assays can include: a housing defining a positioning receptacle to receive the sample; an excitation source to generate incident light directed at the sample; at least one solid-state photomultiplier detector configured to: i) receive a light emitted by at least one label associated with the binding agents and/or analyte complexes within the sample; and ii) produce a signal in response to receiving the light emitted by the at least one label or substrate solution that is physically or chemically modified by the said label, the at least one detector being connected to integrated signal processing electronics to process the signal; and a user interface in communication with the signal processing electronics for conveying one or more results of the one or more biochemical as says.

The present disclosure concerns an apparatus (10) and method for reading out an optical chip (20). A light source (13) is arranged for emitting single mode source light (S1) from its emitter surface (A1) towards an optical input (21) of the optical chip (20). A light detector (14) is arranged for receiving measurement light (S2) impinging onto its receiver surface (A2) from an optical output (22) of the optical chip (20), and measuring said received measurement light (S2). The emitted source light (S1) is aligned to enter the optical input (21) of the optical chip (20) and the measurement light (S2) is aligned back onto the receiver surface (A2). The receiver surface (A2) is larger than the emitter surface (A1) for facilitating the overall alignment.

A disposable photometric measurement tip comprising a polymer tip, the polymer tip having a capillary filling channel, the capillary filing channel having an opening at a distal end of the polymer tip, a wave guide channel acting as an optical input coupling and a wave guide channel acting as an optical output coupling, each of the wave guide channels having an opening at a proximal end of the polymer tip wherein the capillary filling channel, the wave guide channel acting as an optical input coupling and the wave guide channel acting as an optical output coupling are connected to each other.

Systems and methods are used to couple an optical sampling probe to a port in a single-use bioreactor bag for in-process monitoring. A combination of re-useable and disposable components maintain precision while reducing costs. A disposable barb with an integral window, received by the port of the reaction vessel, is coupled to a re-useable optic component with a focusing lens. A separate focus alignment tool is used to set the lens position to a precise focal point before placement of the optic component into the barb. The fixture includes a window to simulate the window in a barb component, a target with a known spectral signature, and a probe head coupled to a spectral analyzer. The axial position of the lens is adjusted with respect to the spacer component to maximize the spectral signature from a sample target, whereupon the spacer component is bonded to the lens mount.

A portable device for detecting an analyte associated with a target organic molecule in a liquid and/or solid substance. The device includes a test chamber, a probe, and a sensor. The test chamber contains a liquid volume of test solution including an analytical reagent selected to react with the analyte. The test chamber is sealed by a pierceable membrane wall. The probe is removably positionable to pierce the membrane wall to deposit a sample in the test chamber to form a test mixture with the test solution. The sensor is positioned to detect one or more characteristics of the test mixture in the test chamber indicative of a reaction between the analyte and the analytical reagent.

A method includes providing a cuvette containing a fluid sample having a first substance and emitting light from a light source through the cuvette containing the fluid sample for a duration of time. The cuvette is made of a material that at least partially dissolves in the presence of the first substance. Over the duration of time, the cuvette at least partially dissolves and an intensity of light that passes through the cuvette and the fluid sample changes at a rate. The method also includes receiving, by a light detector, the light that passed through the cuvette, measuring a change in intensity of the received light over the duration of time, and determining that the rate of change in intensity of the light over the duration of time is greater than a threshold rate of change.

The present invention relates to a system for conducting the identification and quantification of micro-organisms, e.g., bacteria in biological samples. More particularly, the invention relates to a system comprising a disposable cartridge and an optical cup or cuvette having a tapered surface; wherein the walls are angled to allow for better coating and better striations of the light, an optics system including an optical reader and a thermal controller; an optical analyzer; a cooling system; and an improved spectrometer. The system may utilize the disposable cartridge in the sample processor and the optical cup or cuvette in the optical analyzer.