Devices and systems are provided herein relating to a novel and rapid assay for tissue staining. Methods for using the devices and systems for analyzing tissue samples are also disclosed.

Disclosed herein are seals for liquid-tight bonding of an optical window comprising a BiIn alloy. Also disclosed are optical cells comprising the BiIn alloy seals to provide a liquid-tight seal between a cell housing and a drilled optical window.

A cuvette comprising a pyramidal shaped cavity with four sides surfaces, which are connected to each other by curves, wherein side surfaces and curves merge into a transition area that is located above a ring followed by a cone above the bottom of the pyramidally shaped cavity.

The invention relates to a counting chamber for a microscope, adjustable in height. The method measures a cell count at two different chamber heights and deduces the concentration of particles without an exact calibration of the absolute height, as the height difference gives a measurement of the missing volume and therefore an estimate of the particle concentration.

Provided herein are an optical test platform and corresponding method of manufacturing the same. The test platform may include a shell defining a cavity for receiving a sample tube, a first aperture, and a second aperture. The first aperture and the second aperture of the shell may each be configured to optically couple the cavity with an exterior of the shell. The test platform may further include a first window and a second window embedded in the shell. The first window may seal a first aperture and the second window may seal a second aperture. The first window and second window may each permit the optical coupling of the cavity with the exterior of the shell. The first window and the second window may be optically coupled via the cavity, and the shell may prohibit optical coupling between the first window and the second window through the shell.

A flow cell assembly (16) for a fluid analyzer (14) that analyzes a sample (12) includes (i) a base (350) that includes a base window (350B); (ii) a cap (352) having a cap window (352B) that is spaced apart from the base window (350B); and (iii) a gasket (360) that is secured to and positioned between the base (350) and the cap (352), the gasket (360) having a gasket body (360A) that includes a gasket opening (360B). The gasket body (360A), the base (350) and the cap (352) cooperate to define a flow cell chamber (362). Moreover, an inlet passageway (366) extends into the flow cell chamber (362) to direct the sample (12) into the flow cell chamber (362); and an outlet passageway (368) extends into the flow cell chamber (362) to allow the sample (12) to exit the flow cell chamber (362).

The invention pertains to a system for operando measurements that comprises, a reactor (1) comprising a reactor chamber (9) having at least one window (19) transparent for radiation for irradiating a sample (24) provided inside the reaction chamber (9), a radiation source (21, 31) for generating the radiation for irradiating the sample (24), wherein the radiation source (21, 31) is arranged to irradiate the sample at an irradiation location situated on the sample; a detection unit (26, 33) for detecting radiation scattered, emitted, reflected or diffracted by the sample (24) or transmitted through said sample (24), a sampling capillary (12) comprising an orifice (14) for collecting a fluid sample inside the reactor chamber (9), wherein the orifice (14) of the sampling capillary (12) is arranged at a fixed position relative to the irradiation location,
wherein the reactor (1) is movable relative to the radiation source (21, 31).

A light-emitting module for use in a system for measuring whole-blood hemoglobin parameters or whole-blood bilirubin parameters. The light-emitting module includes an LED light source capable of emitting light wherein the light is directed thereby defining an optical path and a plurality of optical components. The plurality of optical components includes a collimating lens, a first optical diffuser, a circular polarizer, and a focusing lens wherein the plurality of optical components is disposed within the optical path of the light from the LED light source.

A flowcell device, including a flow pathway and an optical subassembly, has a flowcell body that is continuous with a sample being analyzed and a temperature controlled surface. The flowcell body can be disposed between a thermalplate, actively regulated by a thermoelectric cooler, and an insulating member. The flowcell device can be employed in a bioreactor monitoring system.

A method for detecting and counting particles suspended in fluids, such as bacteria suspended in urine, utilizing dynamic features of the suspended particles and employing light scattering measurements. The disclosed method is suitable for determining the susceptibility of bacteria to antibiotics. A cuvette for detecting bacteria in fluids, which is especially suited for the light scattering measurements, is provided.