A vibrometer may measure acoustic responses in portions of a structure along a scan path to acoustic excitation of the structure. A ranging device may measure distances to the portions of the structure along the scan path. A three-dimensional point cloud may be generated based on the acoustic responses in the portions of the structure and the distances to the portions of the structure. The three-dimensional point cloud may include points representing geometry of the portions of the structure. The points may be associated with the acoustic responses in corresponding portions of the structure. One or more properties of the structure may be determined based on an analysis of the three-dimensional point cloud.

Systems and methods are provided for imaging of soft and hard tissues with ultrasound. Such systems and methods can provide for non-contact and quantitative ultrasound images of bone and soft tissue. A method for imaging a biological body segment of soft and hard tissues includes setting geometry and material properties according to a model of the biological body segment to thereby generate a simulated time series data set. The method further includes collecting reflective and transmissive time series data of the biological body segment to thereby form an experimental time series data set and minimizing a difference between the simulated time series data set and the experimental time series data set, thereby imaging the biological body segment. Regularizing travel-time and/or using full waveform tomographic techniques with level set methods enable recovery of cortical bone geometry.

Disclosed are a method of inspecting a printing quality of a 3D printing object using a femtosecond laser beam during a 3D printing process, and an apparatus and a 3D printing system for the same. A laser beam is irradiated from a femtosecond laser source disposed coaxially with a 3D printing laser source to inspect a state of the printing object. The laser beam generated by the femtosecond laser source is separated into a pump laser beam and a probe laser beam. The printing laser beam irradiated from a 3D printing laser source or the pump laser beam is irradiated onto a printing object to generate ultrasonic waves. To measure the ultrasonic waves, a probe laser beam is irradiated onto the printing object. The probe laser beam reflected by the printing object is detected. The quality of the printing object is inspected by analyzing the reflected probe laser beam.

A photoacoustic imaging system is disclosed that includes an ergodic relay coupled optically to a light source configured to produce a light pulse and further coupled acoustically to a transducer. The ergodic relay is further configured to direct at least two PA signals to the transducer. Each of the at least two PA signals are produced at different positions within the field of view of the object to be imaged in response to illumination by a single light pulse. The transducer detects each of the at least two PA signals after each of at least two delays that correspond to the position at which each PA signal was produced.

The invention relates to a device and an according method for hybrid optoacoustic and ultrasonographic imaging of an object (1), comprising an irradiation unit (2, 3) for irradiating the object (1) with electromagnetic radiation, in particular light, and a transducer unit (4) comprising a plurality of transducer elements (5), the transducer elements (5) being configured to emit ultrasound waves impinging on the object (1) and to detect ultrasound waves which are reflected and/or transmitted by the object (1) upon impinging on the object (1), and to detect ultrasound waves which are generated in the object (1) upon irradiation with electromagnetic radiation, wherein the transducer elements (1) are arranged along a curved line, in particular a concave line, or a curved surface, in particular a concave surface.

This invention relates a biomarker detection system, for detecting cancer biomarkers using optical heterodyning. The system includes a tunable laser configured to produce a plurality of laser beams of at least two frequencies, a pair of optical fibers coated with gold nanoparticles and functionalized with an antibody is configured to undergo a change of fiber surface of each optical fiber by adsorbing molecules of an analyte on a surface of the antibody, modify a reflection of the plurality of laser beams inside a fiber core of the each optical fiber when the each optical fiber is bent, and create an audible beat frequency; and perform spectral analysis. A frequency spectrum analyzer configured to provide a composition information of the adsorbed molecules based on a spectral analysis of the beat frequency.

The laser device includes a laser crystal, a resonator including a pair of mirrors between which the laser crystal is interposed, a Q switch that is disposed on an optical path of the resonator and controls a Q value of the resonator, and a Brewster thin-film polarizer that is disposed on the optical path of the resonator and transmits selectively p-polarized light. The thin-film polarizer has wavelength selectivity in which a p-polarized light transmittance at a first wavelength exhibiting a maximum gain of the laser crystal is 5% or more to 25% or less, the p-polarized light transmittance monotonically increases as a wavelength becomes longer than the first wavelength, and a maximum transmittance is exhibited at a third wavelength. The laser device oscillates laser light at a second wavelength that is a wavelength longer than the first wavelength and shorter than or equal to the third wavelength.

An adapter for a container that provides an integrated photoacoustic microscopy system that is capable of real time imaging of samples within the container. The adapter allows a researcher or investigator to evaluate a sample using the photoacoustic effect, with or without a microscope. The adapter comprises a support portion, a planar portion, and a tube. The support portion includes a channel formed therein, the channel including a first surface, a second surface opposite the first surface, and an intermediate surface positioned between the first surface and the second surface, the channel configured to receive the rim of the container such that the intermediate surface of the channel is positioned adjacent a top surface of the rim and the first surface and the second surface extend along opposite sides of the sidewall. The planar portion is coupled to the support portion and extends across the opening of the container. The tube is coupled to and extends from the planar portion, the tube defines a bore having an axis, the axis being oriented at an angle relative to the planar portion, the bore configured to receive a photoacoustic transducer for real time imaging of a sample within the container.

A microscale photoacoustic sensor uses the detection of ultrasound waves generated by a sample in response to incident light absorption to perform photoacoustic spectroscopy, imaging, and microscopy. The microscale photoacoustic sensor, including components to excite a sample and detect ultrasound waves, may be integrated onto a single chip. The microscale photoacoustic sensor may excite a sample using a metasurface collimator. The metasurface collimator includes an array of diffraction grooves to collimate an excitation beam uniformly out of the plane of the sensor to create a wide and homogeneous beam spot. The microscale photoacoustic sensor may detect ultrasound waves using an optical photoacoustic transducer. The optical photoacoustic transducer includes a resonator on a mechanical membrane to detect ultrasound waves with high sensitivity. The microscale photoacoustic sensor may be used in applications such as deep-tissue neural imaging or microfluidic biological screening.

A method and a system for photoacoustic inspection of a part are provided herein. The method may include the following steps: photo-acoustically exciting a predetermined position in a predetermined region on a part by pulsed laser illumination, to yield ultrasonic excitation of the part; coherently illuminating a predetermined location in the predetermined region on the part; detecting an illumination scattered from the predetermined location; determining, based on the scattered illumination, a plurality of sequence of two or more temporally-sequential de-focused speckle pattern images, wherein each of the sequences corresponds to one of the predetermined illuminated locations; and determining a set of translations, each determined based on the sequences, wherein each translation in the set is determined based on two temporally-sequential speckle patterns images in the respective sequence.