The present disclosure relates to devices and methods configured to perform drug screening on cells. At least one embodiment relates to a lens-free device for performing drug screening on cells. The lens-free device includes a substrate having a surface. The lens-free device also includes a light source positioned to illuminate the cells, when present, on the substrate surface with a light wave. The lens-free device further includes a sensor positioned to detect an optical signal caused by illuminating the cells. The substrate surface includes a microelectrode array for sensing an electrophysiological signal from the cells.

An electro-optic modulator is a liquid-crystal-based electro-optical light modulator. The liquid-crystal-based electro-optical light modulator is fabricated using surface Micro-electromechanical Systems (MEMS) techniques. The electro-optical light modulator is used for inspecting flat panel displays or the like. Utilizing surface MEMS techniques for fabrication considerably thins the electro-optic modulator and allows the use of pure liquid crystal without the need for thick containment plates.

Provided herein are systems for the label-free detection of target molecules in samples. The systems include a sensor probe positioned in a sensing region and configured to bind to receptors for the target molecules. The systems also include electrodes configured to expose the sensor probe to an alternating electric field, and a light source optically coupled to the sensor probe and configured to provide light along a length of the sensor probe. In addition, the systems also include a position sensitive photodetector configured to detect a position of light exiting the sensor probe, and a processor configured to assess, based at least in part on the position of the light exiting the sensor probe, an amplitude of oscillation of the sensor at a frequency of the alternating electric field and a direction of a displacement of the sensor. Additional systems and related methods are also provided.

The present invention is directed to devices and systems for rapidly producing high resolution images of magnetic fields in a sample. The devices and systems employ diamond chips with color centers that fluoresce in the presence of magnetic fields. The high resolution is due to the use of one of three excitation methods. The first method employs modulation of an acoustic surface wave, which increases/decreases the sensitivity of the color centers to magnetic fields. The second and third methods employ arrays of magnetic field coils and electrode pairs, respectively, which again increase/decrease the sensitivity of the color centers to magnetic fields. The color centers are preferably nitrogen vacancies in the diamond chips.

Implementations disclosed describe, among other things, a sample inspection system that includes an illumination subsystem to generate a light incident on a sample. The sample inspection system includes a collection subsystem having optical elements to collect a light generated upon interaction of the incident light with the sample. The sample inspection system further includes a light detection subsystem configured to detect the collected light and generate one or more signals representative of characteristics of the sample. The sample inspection system deploys a phase mask that interacts with the incident light and/or the collected light and includes a first region and a second region imparting different phases to the light incident on the phase mask.

Provided herein are systems for the label-free detection of target molecules in samples. The systems include a sensor probe positioned in a sensing region and configured to bind to receptors for the target molecules. The systems also include electrodes configured to expose the sensor probe to an alternating electric field. and a light source optically coupled to the sensor probe and configured to provide light along a length of the sensor probe. In addition, the systems also include a position sensitive photodetector configured to detect a position of light exiting the sensor probe, and a processor configured to assess. based at least in part on the position of the light exiting the sensor probe. an amplitude of oscillation of the sensor at a frequency of the alternating electric field and a direction of a displacement of the sensor. Additional systems and related methods are also provided.

An imaging element for analysis of a sample includes an electrode adapted to receive the sample, a light-emitting element, disposed opposite the electrode, and separated from the electrode by an insulating protective layer, a voltage-controlled current source configured to supply current to the light-emitting element and comprising a control electrode electrically connected to the electrode, so that said light-emitting element generates a light wave in response to a voltage coming from the sample.

An optical inspection apparatus includes a stage that supports a target substrate, the target substrate including a plurality of light emitting elements, a jig that applies an electrical signal to the target substrate, the jig including a regulation resistor, a microscope that generates magnified image data of the target substrate, a camera that captures the magnified image data to generate a color image of the target substrate, and an optical measurement unit that captures the magnified image data of the target substrate to generate a spectrum image and measure optical characteristics of the target substrate.

A measurement apparatus and method based on a photon number resolving detector (3). The measurement apparatus comprises a sample holder (1), a coherent light source (2), and the photon number resolving detector (3). The sample holder (1) is configured to be able to receive a sample (200), and is further configured to be able to accommodate the sample (200) for chemical reaction, adjust the temperature of the sample (200), and adjust the mechanical and motion states of the sample (200). The coherent light source (2) is configured to be able to emit incident light towards the sample (200) on the sample holder (1). The photon number resolving detector (3) is configured to be able to measure data of transmitted light, reflected light, and scattered light passing through the sample (200) on the sample holder (1) and perform statistics and analysis so as to obtain statistical photon characteristics of the transmitted light, the reflected light, and the scattered light.

The present disclosure relates to methods and apparatus for characterising an interaction between a stimulus and a liquid thin film. An aspect of the disclosure provides a spectroscopic ellipsometry apparatus for characterising an interaction between a stimulus and a liquid thin film, the apparatus comprising: a stimulator, configured to provide a stimulus to a liquid thin film disposed on a volume of liquid to generate a wave in the liquid thin film, the liquid thin film and the volume of liquid having an interface therebetween, light beam optics for illuminating an area of the liquid thin film with a light beam, the light beam having a first polarisation, and a light collector coupled to a detector for receiving the light beam after reflection by the liquid thin film, the light beam having a second polarisation after reflection by the liquid thin film; a wave measurement module coupled to the light collector and configured to provide surface wave data to characterise a Lucassen wave in the liquid thin film based on the second polarisation.