Disclosed herein is a biosensor for optical detection of Brownian relaxation dynamics of magnetic particles measured by light transmission. The magnetic particles can be functionalized with biological ligands for the detection of target analytes in a sample. The setup may be implemented in a disc and optical pick-up head configuration.

An opto-magnetic device includes an integrated optical circuit having an input for an input optical radiation and at least one output for an output optical radiation. The optical circuit defines an area sensible to the variations of a local refraction index probed by the optical radiation, destined to come in contact with the sample. A plurality of probe molecules are included to anchor to the sensible area, and a plurality of magnetic particles are included to anchor to molecules of the analyte, bound to the probe molecules upon a molecular recognition. A magnetic actuator is configured to generate a variable magnetic field and oscillate the magnetic particles to cause variation of the refraction index probed by the optical radiation in the sensible area, and a variation of at least one characteristic parameter of the output optical radiation correlated to a concentration of the molecules of the analyte.

A device is disclosed, including: a plate including a sample deposition tube adapted to receive a sample comprising one or more analytes, the sample deposition tube defining a vertical axis substantially perpendicular to a main surface of the plate; and a mirror positioned to project, substantially parallel to the main surface of the plate, an image of the sample deposition tube along its vertical axis, so as to allow determination of the vertical location of the one or more analytes inside the sample deposition tube. Methods for determining the density of one or more analytes using various embodiments of the device are also described.

A method for determining at least one property of magnetic matter includes: applying a magnetic field to magnetic matter; directing first light on the magnetic matter at a first set of incident angles; receiving a first set of signatures associated with the first light scattered from the magnetic matter; varying orientation of the magnetic matter with respect to the magnetic field; directing second light on the magnetic matter at a second set of incident angles; receiving a second set of signatures associated with the second light scattered from the magnetic matter; determining, by processing the first set and the second set of signatures according to a dispersion relation, at least one property of the magnetic matter.

Many samples (inorganic and organic) have magnetic properties. This adaptor which is comprised of an electromagnet and a sample holder (slide) can be directly mounted on a standard microscope (upright or inverted). The magnetic field is uniform across the sample and can be modified (due to the electromagnet design). The mount allows changing the field while simultaneously imaging the sample. Notably, the universality of the adaptor design will allow it to enable a wide range of investigations, impacting numerous fields.

The present invention provides a magnetic-control measurement system, comprises a reaction container and a programable magnetron measurement unit. The reaction container is configured to fill a target suspension having a plurality of magnetic nanoparticles (MNPs); the programable magnetron measurement unit comprises: an opaque housing, a loading platform is configured to place the reaction container, a light-emitting device is configured to generate a high directional light through the reaction container, a magnetic field generator is disposed on opposite two sides of the loading platform for generating an alternating magnetic field forced on the reaction container in an operating time, a sensing device is configured to detect a light intensity variance of the high directional light through the reaction container, a processor is configured to calculate a value and an efficiency of absorption of the target suspension, and a display is communicatively coupled to the processor, to display the value and the efficiency of absorption of the target suspension.

The present disclosure is directed towards characterizing liquids through the use of magnetic discs that rotate in response to dynamic magnetic fields. In some embodiments, a light beam is transmitted into the liquid while the magnetic discs rotate, and one or more parameters of a light beam signal associated with the transmitted light beam are identified. Various characteristics of the liquid may be detected based on the one or more parameters of the light beam signal.

The present disclosure provides a complex having satisfactory dispersibility and stable luminescence characteristics. A complex of the present disclosure includes: a first substance having a property of specifically binding to a target substance; a quantum dot that contains silicon as a main component and that is negatively charged on a surface; and a linker substance that contains a compound represented by general formula (1) below and that covers the surface of the quantum dot, where the first substance has been immobilized on the surface of the quantum dot through the linker substance:

X—L—Si—(R.sub.1)(R.sub.2)(OR.sub.3)  (1)

where X is a basic functional group; R.sub.1, R.sub.2, and R.sub.3 are each independently an alkyl group; and L is an alkylene group.

A specimen measurement device which detects a measurement object material according to the present embodiment, includes: a magnetic field applicator configured to apply a magnetic field to a measurement cartridge including a substrate, a first substance fixed on the substrate and specifically reacting with the measurement object material, a magnetic particle, and a substance fixed on the magnetic particle and specifically acting with the measurement object material; a detector configured to detect light passing through the substrate; and a controller configured to control the magnetic field applicator to perform a first operation to apply a first magnetic field in a direction to move the magnetic particle away from the substrate when a specimen solution containing the measurement object material is introduced into the measurement cartridge, and then perform a second operation to apply a second magnetic field in a direction to move the magnetic particle toward the substrate.

A method of extracting and detecting paramagnetic material in an aqueous medium, the method including: loading a sample into a holder in a cavity enhancement module; directing light from a light source to the sample in the holder; applying an oscillating magnetic field to the sample in the holder; determining a first level of transmittance with the oscillating magnetic field in a first state; determining a second level of transmittance with the oscillating magnetic field in the second state; and determining a change in transmittance of the light from the sample based on the first level of transmittance and the second level of transmittance.