A device including a housing, a zone and a means for testing a fluid sample within the housing is disclosed. The housing is constructed of a fluid impermeable material, and defines a first fluid port, and a second fluid port. The first fluid port is configured to connect to a fluid collection device to receive a fluid sample from the fluid collection device into the housing. The second port is configured to pass the fluid sample from the housing into a testing instrument. The zone is formed in the housing. The zone is constructed of a material that allows an analysis of the fluid sample positioned within the housing, and located adjacent to the zone.

In order to analyze a solution component and a scatterer component in a liquid sample more quickly, there is provided an optical analysis device including a light source unit configured to irradiate a liquid sample with light; a first light receiving unit configured to receive transmitted light emitted from the light source unit and transmitted through the liquid sample; a second light receiving unit configured to receive scattered light emitted from the light source unit and scattered by a scatterer in the liquid sample; an ultrasonic irradiation unit configured to irradiate the liquid sample with an ultrasonic wave; a reflection plate configured to reflect the ultrasonic wave that is emitted from the ultrasonic irradiation unit and propagated through the liquid sample; and a control unit configured to control the light source unit, the first light receiving unit, the second light receiving unit, and the ultrasonic irradiation unit.

A method is provided for manipulating objects in a cavity including a liquid, the method including providing in at least one region of the cavity objects capable of absorbing light in a given wavelength range, forming an aggregate of the objects by submitting them to an acoustic field, and disrupting the aggregate by submitting the aggregate to a light beam emitting at the given wavelength range. Also provided is a device for manipulating objects.

The disclosed apparatus, systems and methods relate to ATPA technology that provides a method for the real-time assessment of the polymerization of a sample, e.g., whole blood or blood plasma coagulation, by a non-contact acoustic tweezing device. The acoustic tweezing technology integrates photo-optical tests used in plasma coagulation assays with mechanical (viscoelastic) tests used in whole blood analysis. Its key disruptive features are the increased reliability and accuracy due to non-contact measurement, low sample volume requirement, relatively short procedure time (less than 10 minutes), and the ability to assess the level of Factor XIII function from measurements of the fibrin network formation time.

Methods, devices and apparatus for measuring expansion/contraction properties of a material are described. According to an embodiment a method comprises: providing a device, said device comprising a sample comprising said material, said sample comprising a first surface and a second surface, a first substrate and a second substrate connected to said first surface and to said second surface of said sample, respectively, a reflective material attached to said second substrate, and two electrical contacts each independently in contact with said sample; applying voltage to said sample using said electrical contacts; illuminating said reflective material using a light source, such that said illumination comprises light having known and controllable polarization; collecting light reflected off said reflective material; measuring amplitude and phase of an oscillating change in polarization of the reflected light; and extracting parameters related to expansion/contraction from said reflected light measurement, thus evaluating said expansion/contraction properties of said material.

The disclosed apparatus, systems and methods relate to ATPA technology that provides a method for the real-time assessment of the polymerization of a sample, e.g., whole blood or blood plasma coagulation, by a non-contact acoustic tweezing device. The acoustic tweezing technology integrates photo-optical tests used in plasma coagulation assays with mechanical (viscoelastic) tests used in whole blood analysis. Its key disruptive features are the increased reliability and accuracy due to non-contact measurement, low sample volume requirement, relatively short procedure time (less than 10 minutes), and the ability to assess the level of Factor XIII function from measurements of the fibrin network formation time.

The invention comprises an applied force-optic analyzer used to determine a sample constituent concentration, a physical measure of the sample, and/or a state of the sample. The analyzer comprises: an electro-mechanical transducer affixed to skin of a subject; a controller, the controller providing a voltage waveform to the electro-mechanical transducer driving displacement of the skin and inducing a pressure wave into the skin; and a spectrometer interfaced to a sample site of the skin, the spectrometer comprising a set of sources and a set of detectors, where the controller is configured to collect signal from the set of detectors as a function of timing of the voltage waveform and apply a calibration model to the signal to determine the analyte concentration.

In order to analyze a solution component and a scatterer component in a liquid sample more quickly, there is provided an optical analysis device including a light source unit configured to irradiate a liquid sample with light; a first light receiving unit configured to receive transmitted light emitted from the light source unit and transmitted through the liquid sample; a second light receiving unit configured to receive scattered light emitted from the light source unit and scattered by a scatterer in the liquid sample; an ultrasonic irradiation unit configured to irradiate the liquid sample with an ultrasonic wave; a reflection plate configured to reflect the ultrasonic wave that is emitted from the ultrasonic irradiation unit and propagated through the liquid sample; and a control unit configured to control the light source unit, the first light receiving unit, the second light receiving unit, and the ultrasonic irradiation unit.

A Quantitative Phase Imaging system uses acoustic pressure waves and has capability to measure the nano-mechanical disturbances formed on the cell. By means of the obtained images, cell hardness can be measured and the pato-physiologic features of the cancer cells shall be characterized. By means of this method where mechanical interaction is not directly used, it is aimed to display the characteristic vibration rings formed by the acoustic vibration rings on the cancer sample.

The disclosed apparatus, systems and methods relate to ATPA technology that provides a method for the real-time assessment of the polymerization of a sample, e.g., whole blood or blood plasma coagulation, by a non-contact acoustic tweezing device. The acoustic tweezing technology integrates photo-optical tests used in plasma coagulation assays with mechanical (viscoelastic) tests used in whole blood analysis. Its key disruptive features are the increased reliability and accuracy due to non-contact measurement, low sample volume requirement, relatively short procedure time (less than 10 minutes), and the ability to assess the level of Factor XIII function from measurements of the fibrin network formation time.