A cell survival rate determining device includes a distribution acquisition unit acquiring a particle size distribution in a solution containing particles including cultured cells; a classification unit classifying the particles into a small particle group and a large particle group using a predetermined threshold in the distribution; a ratio calculation unit calculating the value of a ratio between the number of particles belonging to the small particle group and the number of particles belonging to the large particle group; and a survival rate determination unit determining the survival rate of the cultured cells from the value of the ratio using a pre-acquired relationship between the ratio and cell survival rate.

An objective of the present invention is to provide an optical measurement device capable of performing remote optical measurement. An optical measurement device may include a light source that generates irradiation light with a beam shape, a beam control unit configured to control an irradiation direction of the irradiation light L1, a condensing unit configured to condense returned light generated by irradiating a part of a measurement target with the irradiation light, and a detection unit configured to detect information regarding the measurement target included in the returned light condensed by the condensing unit. The beam control unit can control the irradiation direction of the irradiation light for measurement to any direction, and thus the condensing unit can efficiently receive the faint returned light from the measurement target.

A system and method are provided for distributed acoustic sensing in a multicore optical fiber. The system includes a transmitter for simultaneously propagating a sequence of M light pulses through the multicore optical fiber using a spatial mode selected from a set of N spatial modes provided by a spatial mode selector for the transmitter that is coupled to an input to the multicore optical fiber, with M and N being respective integers greater than one. The system further includes a receiver for receiving the sequence of M light pulses at an output of the multicore optical fiber and detecting an environmental perturbation in the multicore optical fiber based on an evaluation of a propagation of the sequence of M light pulses through the multicore optical fiber.

Embodiments of the invention comprise apparatus and methods for detecting the presence of a substance in a test material using a plurality of wavelength-specific couplers (e.g. tilted fiber gratings) which provide a spatially distributed multi-node all-optical measurement system. Each node of the measurement system can comprise an optical module that is sensitive to the intensity of a limited band of wavelengths. The node is thus capable of detecting the presence of an absorption peak in a spectrum without having to obtain the full spectrum. By providing a plurality of optical modules that are sensitive to different wavelengths, the spectral signature of different substances may be monitored without having to measure full spectra. The measurement system may be particularly useful in a process control environment where it is desirable to take measurements of one or more substances in different locations.

An apparatus and related method for determining the optical density and/or change in optical density of a reaction mixture in an agitated vessel or container. The apparatus may include at least one electromagnetic emitter configured to pass radiation through the reaction mixture to at least one receptor, whereby the receptor receives the transmitted or scattered light, while the reaction mixture is subjected to shaking. The emitters may have an interchangeable association with the vessel or container and/or the receptors may have an interchangeable association with the vessel or container. Further, a processor may be provided to receive the transmitted or scattered light data and filter to eliminate or reduce the effect of the frequency at which the reaction mixture is shaken. The processor analyzes the filtered data to provide the optical density and/or change in optical density of the reaction mixture.

A system and method are provided for distributed acoustic sensing in a multimode optical fiber. The system includes a transmitter for simultaneously propagating a sequence of M light pulses through the multimode optical fiber using a spatial mode selected from a set of N spatial modes provided by a spatial mode selector for the transmitter that is coupled to an input to the multimode optical fiber, with M and N being respective integers greater than one. The system further includes a receiver for receiving the sequence of M light pulses at an output of the multimode optical fiber and detecting an environmental perturbation in the multimode optical fiber based on an evaluation of a propagation of the sequence of M light pulses through the multimode optical fiber.

A system and method are provided for distributed acoustic sensing in a multicore optical fiber. The system includes a transmitter for simultaneously propagating a sequence of M light pulses through the multicore optical fiber using a spatial mode selected from a set of N spatial modes provided by a spatial mode selector for the transmitter that is coupled to an input to the multicore optical fiber, with M and N being respective integers greater than one. The system further includes a receiver for receiving the sequence of M light pulses at an output of the multicore optical fiber and detecting an environmental perturbation in the multicore optical fiber based on an evaluation of a propagation of the sequence of M light pulses through the multicore optical fiber.

The present invention provides improved methods for characterizing kinetics and thermodynamics of solutions containing macromolecules over a range of concentrations, temperatures, pH, and added excipients in order to improve their long term stability.

An automatic analysis device has a plurality of types of photometers having different quantitative ranges, and an analysis control unit for quantifying the desired component in specimens based on measurement values of one or more photometers selected from among the plurality of types of photometers. The analysis control unit: sets a switching region in an overlap region of respective quantitative ranges of the plurality of types of photometers, said switching region having a greater width than does the variation in quantitative values of the desired component based on the measurement values of photometers having the same specimen; compares the quantitative value of a quantitative range portion that corresponds to the switching region and the quantitative values of the desired component based on the measurement values of the photometers; and selects a photometer to be used in quantitative output of the desired component from among the plurality of types of photometers.

Methods and systems for performing lavage. The method may include providing an irrigation fluid to a surgical area. The method may also include removing via at least one suction line the irrigation fluid and medical waste at the surgical area to generate a fluid stream in the at least one suction line. The method may also include analyzing the fluid stream based on spectroscopy to generate a result. The method may also include generating a feedback signal based on the result. The method may also include when the feedback signal indicates a negative result, lavage is complete and the surgical area is closed, and when the feedback signal indicates a positive result, lavage is not complete and the method of performing lavage is repeated.