The present disclosure relates to a novel absorbance-based colorimetric device system, and to methods of using the novel absorbance-based colorimetric device system.

Disclosed is a device including a substrate having a plurality of detection areas to receive at least a portion of a sample having an analyte or suspected of having an analyte and at least one reference marker adjacent to at least one of the detection areas, wherein each of the detection areas detects a specific analyte and the at least one reference marker defines a scale mark, a shape mark, a color mark, or a combination thereof. Also disclosed is an imaging system and method for using the device and imaging system.

Systems, apparatuses, and methods are described herein for disease detection using an analyte-agnostic approach. Such systems, apparatuses, and methods can include using an array with hydrogels disposed on a substrate, where the hydrogels include one or more polymerized monomers and one or more photoinitiators or photocleavage products thereof. One or more samples including one or more unlabeled analytes can be contacted with an array of polymers. The samples disposed on the array can be incubated for a first predetermined period of time, and heated at a predetermined temperature for a second predetermined period of time. An imaging device (e.g., flatbed scanner) can be used to measure an amount of one or more colorimetric or luminescence signals produced by the array after the incubating and heating. A neural network trained using the samples can then be used to predict a diagnostic or disease class for the sample.

There is provided a paper-based colorimetric sensor kit for quickly and simply diagnosing mercury in situ with a naked eye. The paper-based colorimetric sensor kit includes: a circular template for rolling circle amplification (RCA); a primer that does not hybridize to the circular template when a mercury ion is bonded to a primer that hybridizes to the circular template; a DNA polymerase; a sensing material kit including a nanoparticle probe labeled to a DNA coil formed in the circular template for RCA; and a radial chromatography paper.

Embodiments described herein generally relate to: sensing and/or authentication using luminescence imaging; diagnostic assays, systems, and related methods; temporal thermal sensing and related methods; and/or to emissive species, such as those excitable by white light, and related systems and methods.

The present disclosure is directed to techniques for coupling activation of sensor devices with use of authorized products. A system includes a sensor device. The sensor device includes a housing that attaches to an absorbent article configured to absorb and contain bodily exudates. The sensor device further includes at least one sensor formed on or within the housing configured to capture sensor data in association with wear of the absorbent article. The system also includes a processor that executes computer executable components. The computer executable components include a communication component that receives an activation code and an activation component that activates a functionality based on the receipt of the activation code.

The present invention is directed to kits and methods for detecting and discriminating the target pathogens Influenza A Virus and Influenza B Virus and optionally Respiratory Syncytial Virus in a sample and to devices containing said kits and for use in said methods. The invention employs restriction enzymes, polymerase and oligonucleotide primers to produce, in the presence of a target pathogen, an amplification product which is contacted with oligonucleotide probes to produce a detector species.

Disclosed is an instrument analyzing elemental composition of a sample, including a measurement assembly including: an exciter generating an excitation directed at a target position to cause emission from the sample; a detector assembly receiving the emission from the sample at the target position, arranged to generate one or more measurement signals that are descriptive of the emission; an imaging apparatus for capturing images of an area around the target position; and a controller for carrying out a measurement, arranged to operate the exciter to generate the excitation and to carry out analysis of the elemental composition of the sample based on the measurement signals. The controller performs reliability analysis associated with the measurement by operating the imaging apparatus to capture images of the sample, determining estimated reliability of the measurement based on the captured images, and selectively issuing an indication of measurement reliability based on the estimated reliability.

Optical property measurement using a sensor behind a display screen Examples of this application disclose a method for measuring optical properties of a target. The method comprises illuminating the target with an illumination area with a display screen in contact with the target, and analysing signals reflected from the target and transmitted back through the display screen to a sensor positioned behind the display screen, to determine the optical properties of the target.

Single-use diagnostic consumables for use in performing multiple analyses on a fluid sample are provided. The diagnostic consumables include a first sensing region configured for analysis of at least one analyte in a fluid sample that has been received by the diagnostic consumable. The diagnostic consumable further includes a fluid transport material configured to flow a portion of the fluid sample into a second sensing region fluidically connected to the fluid transport material and configured for performing a second analysis of the fluid sample. Methods for performing multiple analyses of a fluid sample on a single-use diagnostic consumable are also provided.