Instruments, systems, and methods for measuring optical density of microbiological samples are provided. In particular, optical density instruments providing improved safety, efficiency, comfort, and convenience are provided. Such optical density instruments include a handheld portion and a base station. The optical density instruments may be used in systems and methods for measuring optical density of biological samples.

A method, computer program product, and apparatus are provided for controlling components of a detection device. The device may detect turbidity of liquid with sensors such as a density sensor and/or nephelometric sensor. A light modulation pattern may reduce or eliminate interference in sensor readings. Readings may be performed during off cycles of an illumination light to reduce interference but to provide improved visibility of a tube. Dark and light sensor readings may be performed with an emitter respectively off or on to account for ambient light in subsequent readings. Readings from the density sensor and/or nephelometric sensor may be used to calculate McFarland values. The device may be zeroed based on an emitter level that results in a sensor reading satisfying a predetermined criterion.

A turbidity calibration-correction apparatus is configured for an automated calibration-correction of a turbidity. The calibration-correction apparatus includes: a turbidity calibration standard configured for calibration of the turbidity measurement apparatus, a memory configured to store an attribute-value including at least a correction-value that is a function of a turbidity value of the turbidity calibration standard measured by the turbidity measurement apparatus, where the calibration-correction is based on the correction-value, and a communicator configured to transfer at least an identity of the turbidity measurement apparatus and the correction-value from the turbidity measurement apparatus to the calibration-correction apparatus.

Apparatuses and associated methods of manufacturing are described that provide a tip resistant optical testing instrument configured to rest on a surface. The optical testing instrument includes a shell defining a cavity for receiving a sample tube. The shell includes a bottom shell surface, wherein the bottom shell surface defines at least one support element, wherein the at least one support element is configured to engage the surface to support the optical testing instrument in a testing position, and a translational surface configured to engage the surface to support the optical testing instrument in an angled position. In an instance in which the optical testing instrument tilts from the testing position to the angled position, the translational surface is configured to engage the surface contacting the translational surface to prevent the optical testing instrument from tipping further and allow the optical testing instrument to return to the testing position.

A hand-held microfluidic testing device is provided that includes a housing having a cartridge receiving port, a cartridge for input to the cartridge receiving port having a sample input and a channel, where the channel includes a mixture of Raman-scattering nanoparticles and a calibration solution, where the calibration solution includes chemical compounds capable of interacting with a sample under test input to the cartridge and the Raman-scattering nanoparticles, and an optical detection system in the housing, where the optical detection system is capable of providing an illuminated electric field, where the illuminating electric field is capable of being used for Raman spectroscopy with the Raman-scattering nanoparticles and the calibration solution to analyze the sample under test input to the cartridge.

A transmissometer and method for determining a transmissivity of an atmosphere within a chamber. A chamber contains the atmosphere. A light source generates a test beam and a light detector detects the test beam. A periscope is movable between a first position which allows the test beam to pass through the atmosphere in the chamber and into the light detector and a second position in which the test beam is deflected to pass into the light detector without passing through the atmosphere in the chamber. A processor determines the transmissivity of the atmosphere from a transmissivity measurement for the test beam obtained by the light detector when the periscope is in the first position and a transfer standard obtained at the light detector when the periscope is in the second position.

A method, computer program product, and apparatus are provided for controlling components of a detection device. The device may detect turbidity of liquid with sensors such as a density sensor and/or nephelometric sensor. A light modulation pattern may reduce or eliminate interference in sensor readings. Readings may be performed during off cycles of an illumination light to reduce interference but to provide improved visibility of a tube. Dark and light sensor readings may be performed with an emitter respectively off or on to account for ambient light in subsequent readings. Readings from the density sensor and/or nephelometric sensor may be used to calculate McFarland values. The device may be zeroed based on an emitter level that results in a sensor reading satisfying a predetermined criterion.

A bidirectional reflectance distribution function (BRDF) measurement system is provided that measures the BRDF across many photonic bands such as the UV, Vis, NIR, SWIR, MWIR, and LWIR (scale) simultaneously (speed) in an innovative measurement system. The measurement system includes an illuminating optical system, a detection system, and a calibration reference. The illuminating optical system directs illuminating light to an imaging location and the detection system detects returning light from the imaging location. The calibration reference including an optical metamaterial having a receiving surface. The calibration reference is placed at the imaging location and alters illuminating light incident on the receiving surface to produce returning light having known optical properties.

Instruments, systems, and methods for measuring optical density of microbiological samples are provided. In particular, optical density instruments providing improved safety, efficiency, comfort, and convenience are provided. Such optical density instruments include a handheld portion and a base station. The optical density instruments may be used in systems and methods for measuring optical density of biological samples.

An optical system that obtains characteristics of a transmission path in atmosphere, when laser light propagates through this transmission path, at a place separated from this transmission path and before the propagation, and corrects wavefront of the laser light based on the obtained characteristics, is provided. The optical system is provided with an irradiation device and an atmospheric characteristics obtaining system. The irradiation device irradiates an external target with light via a first optical path. The atmospheric characteristics obtaining system is arranged in a second optical path separated from the first optical path and obtains characteristics of atmospheric environment in the first optical path with respect to the irradiated light. The irradiation device is provided with wavefront correction optics. The wavefront correction optics correct wavefront of the irradiated light based on the obtained characteristics.