Aspects relate to a spectroscopic analyzer device that can be used for biological sample detection, and specifically for virus infection detection. The spectroscopic analyzer device includes a spectrometer, such as a micro-electro-mechanical systems (MEMS) based infrared spectrometer, and an artificial intelligence (AI) for screening of viral samples. In addition, the spectroscopic analyzer device includes a light source and a disposable optical component configured to receive a sample and to facilitate light interaction with the sample.

The present disclosure relates generally to the field of neurology. In particular, the disclosure relates to a method of detecting a neurodegenerative disease in a subject and methods of treatment thereof. The methods include detecting the level of an exosome-bound aggregated biomarker in a sample obtained from the subject, wherein an increased level of the exosome-bound aggregated biomarker as compared to a reference indicates that the subject is suffering from a neurodegenerative disease. Also described are methods for detecting a subject at risk of developing amyloidosis or a neurodegenerative disease, methods for detecting and treating amyloidosis or a neurodegenerative disease in a subject, and methods of determining the aggregation state of a biomarker in a sample.

A sensor for determining a liquid type, includes: a plano-convex lens; a lens holder configured to support the plano-convex lens via an edge of the lens; an outputting optical fiber that abuts against a plane surface of the plano-convex lens to output light; a light-receiving optical fiber that abuts against the plane surface of the plano-convex lens to receive light; a light-emitting unit connected to the outputting optical fiber; and a light amount measuring unit connected to the light-receiving optical fiber to measure a light amount. The outputting optical fiber is provided so that an end face of the outputting optical fiber is disposed on the edge of the plano-convex lens, and preferably, a central axis thereof at the end face thereof passes through the plane surface of the plano-convex lens.

A device includes capture sites; an imaging system for imaging the capture sites; a memory that stores a map of the capture sites including capture site shapes having respective predefined positions in the map and to be placed on an image of the capture sites, at a predefined position and in a predefined orientation so that the capture site shapes respectively indicate the areas of the image occupied by the capture sites; and a module for detecting an odor from an image of the capture sites and the map. The device includes an update module for obtaining an image of the capture sites, for determining, in the image, real areas respectively occupied by the capture sites, for determining, on the basis of the real areas, a correction of the position and/or of the orientation of the overlay of the map; and for updating the position and/or orientation of the overlay.

A measuring apparatus (100a, 1a) includes a light source (110) configured to emit probe light; a total reflection member (16) in contact with a to-be-measured object and configured to cause total reflection of the probe light that is incident; a light intensity detector (17) configured to detect light intensity of the probe light exiting from the total reflection member (16); an output unit (2) configured to output a measurement value obtained on the basis of the light intensity; a first support (31) supporting the light source (110) and the light intensity detector (17); and a second support (32) provided to the first support (31), detachable from the first support (31), and supporting the total reflection member (16).

A blood biomarker analysis systems providing fast biomarker identification includes a multimodal bioassay device having a biosensor within a portable pipette-shaped device and using nanoplasmonic barcode detectors, such as formed of antibody conjugated gold nanoparticle arrays (AuNPs), capable of capturing any of a plurality of biomarkers. The biomarker analysis system further includes the pipette-shaped device being smartphone-connected and portable to form a highly accurate, point-of-care bioassay device.

Disclosed herein are nanostructured plasmonic materials. The nanostructured plasmonic materials can include a first nanostructured layer comprising: a first layer of a first plasmonic material permeated by a first plurality of spaced-apart holes, wherein the first plurality of spaced apart holes comprise a first array; and a second nanostructured layer comprising a second layer of a second plasmonic material permeated by a second plurality of spaced-apart holes, wherein the second plurality of spaced apart holes comprise a second array; wherein the second nanostructured layer is located proximate the first nanostructured layer; and wherein the first principle axis of the first array is rotated at a rotation angle compared to the first principle axis of the second array.

A method for optically detecting biomarkers in a biosensor is disclosed, wherein the optical detection obtains spatially and spectrally resolved optical signals from a sample on a biosensor, and one or more of these spatially and spectrally resolved optical signals can be analyzed in parallel with image acquisition. The image analysis comprises reading data of the acquired images, correcting them to reduce inhomogeneities and noise, localizing particles in the images, characterizing each particle individually to obtain its position and characterization parameters, and classifying the particles based on their characterization parameters. Using the number of particles per class for all the acquired images of the sample, a statistical value is calculated per sample and each statistical value is correlated with an indication of the presence of a biomarker in the sample.

A measurement system for obtaining information about a sample comprises an excitation-beam source configured for irradiating the sample with an excitation-beam. The measurement system comprises a probe unit configured for exposing the sample to a probing radiation or a probing field, and a detection unit configured for obtaining a first information about an interaction of the probing radiation or the probing field with the sample, if a plasmon or plasmon-polariton was excited by the excitation-beam, and obtaining a second information about an interaction of the probing radiation of the probing field with the sample, if a plasmon or plasmon-polariton was not excited by the excitation-beam.

A fluid sensor includes a support structure having a top main surface region; a thermal emitter on the top main surface region of the support structure; a thermal radiation detector on the top main surface region of the support structure; and a waveguide structure having a first and a second waveguide section on the top main surface region of the support structure. The first waveguide section guides a first portion of the thermal radiation to the thermal radiation detector and the second waveguide section guides a second portion of the thermal radiation to the thermal radiation detector. The waveguide structure enables an interaction of an evanescence field of the guided first and/or second portion of the thermal radiation with a surrounding fluid.