G01N2021/5903

SURFACE PLASMON RESONANCE IMAGING SYSTEM AND METHOD FOR MEASURING MOLECULAR INTERACTIONS
20190360932 · 2019-11-28 · ·

A system in an embodiment can comprise an optical assembly, an SPR light source, and an SPR camera. The optical assembly in this embodiment can comprise a hemispherical prism comprising a planar top surface configured to support a surface-plasmon-resonance (SPR) sensor; a high numerical aperture (NA) lens; and a housing configured to mount the hemispherical prism and the high NA lens the such that the high NA lens is located distal from the planar top surface of the hemispherical prism. The SPR light source in this embodiment can be configured to emit a low-coherent monochromatic light beam for SPR imaging toward the high NA lens. The SPR camera in this embodiment can be configured to capture an SPR image formed after the low-coherent monochromatic light beam is incident upon and reflected by a metal-coated sample contacting surface of the SPR sensor. Additionally, the high NA lens in this embodiment can be configured to refract the low-coherent monochromatic light beam from the SPR light source toward the hemispherical prism; and the hemispherical prism can be configured to collimate the low-coherent monochromatic light beam, as refracted by the high NA lens, toward the SPR sensor. Other embodiments are disclosed.

COMPACT GAS SENSORS
20190353593 · 2019-11-21 ·

Systems and methods herein provide low power non-dispersive infrared (NDIR) gas sensors. The gas sensors comprise a thin film plasmonic light source that produces a time modulated parallel light beam at multiple selected wavelengths. The parallel light beam from the light source passes through a gas chamber without using focusing or collimating optical components. The gas sensors are continuously self-calibrated against environmental changes, such as temperatures and relative humidity, and aging. The gas sensors are suitable for use in hazardous environments because their low power and small thermal mass reduces the risk of explosion. The gas sensors can be integrated into conventional mobile device platforms.

Plasmonic nanohole arrays on hybrid substrate for highly sensitive label-free biosensing

A biosensor device including a metal layer, a transparent substrate layer, and a dielectric layer, wherein the metal layer includes a plurality of sub-wavelength apertures, and wherein the dielectric layer is located between the metal layer and the transparent substrate layer to form a spectrally isolated and well-defined optical transmission resonance through the extraordinary optical transmission (EOT) phenomenon.

Label-free sensing chip and application thereof
10379045 · 2019-08-13 · ·

The present invention provides a label-free sensing chip for identifying a chemical substance, comprising: (a) a transparent substrate comprising a base and first periodic ridges; and (b) a metal layer covering said transparent substrate, comprising second periodic ridges and third periodic ridges, in which said second periodic ridges has a height equal to or greater than the height of the first periodic ridges, and each ridge of the second periodic ridges fits into the space between each ridge of the first periodic ridges, and said third periodic ridges correspondingly located on said first periodic ridges. The present invention also provides a method for identifying a chemical substance by using the foresaid label-free sensing chip.

Surface plasmon-based nanosensors and systems and methods for sensing photons and chemical or biological agents
10329147 · 2019-06-25 · ·

Surface plasmon-based nanosensor, comprising: at least one first element of metal, preferably silver or gold, or of semiconductor, the first element being excitable to surface Plasmon resonance, in particular localized surface plasmon resonance, in the presence of electromagnetic radiation from a source, and at least one second element preferably near the first element that in the presence of the electromagnetic radiation is exciton-plasmon coupled to the first element and emits electromagnetic radiation representative of the exciton-plasmon coupling, and systems and methods for sensing photons and chemical or biological agents.

DETECTION DEVICE

A detection device including a light guide element, a sensing element, a surface plasma resonance layer and a spatial filter element is provided. The light guide element has a top surface and a bottom surface opposite to the top surface. The sensing element is disposed beside the bottom surface of the light guide element. The surface plasma resonance layer is disposed on the top surface of the light guide element and is adapted to receive biopolymers. The spatial filter element is disposed between the bottom surface of the light guide element and the sensing element. The spatial filter element has a plurality of first light channels and a plurality of second light channels. The plurality of first light channels extend in a first direction, the plurality of second light channels extend in a second direction, and the first direction and the second direction are intersected. A normal direction of the top surface of the light guide element and the second direction form an included angle , and the included angle corresponds to a resonant angle of the surface plasma resonance layer.

Surface plasmon-based nanosensors and systems and methods for sensing photons and chemical or biological agents
10239752 · 2019-03-26 · ·

Surface plasmon-based nanosensor, comprising: at least one first element of metal, preferably silver or gold, or of semiconductor, the first element being excitable to surface Plasmon resonance, in particular localized surface plasmon resonance, in the presence of electromagnetic radiation from a source, and at least one second element preferably near the first element that in the presence of the electromagnetic radiation is exciton-plasmon coupled to the first element and emits electromagnetic radiation representative of the exciton-plasmon coupling, and systems and methods for sensing photons and chemical or biological agents.

Wave guide sensor

An embodiment sensor includes a hybrid waveguide. The hybrid waveguide includes a first dielectric optical waveguide lying on and in contact with a dielectric support layer; a first surface waveguide optically coupled to the first dielectric optical waveguide, parallel to the first dielectric optical waveguide, and lying on the dielectric support layer. The first surface waveguide has a lateral surface configured to guide a surface mode. The hybrid waveguide includes a cavity intended to be filled with a dielectric fluid, separating laterally the first dielectric optical waveguide from the lateral surface of the first surface waveguide.

System for biodetection applications

The present invention relates to a system for biodetection applications comprising two basic elements, a substrate with a functionalized surface and a nanoparticle, the system being capable of enhancing the plasmonic effect of the nanoparticle. The invention also relates to a biosensor incorporating such system, in addition to the method for detecting and quantifying a target analyte selected in a sample using such system. Finally, the invention relates to a device which can detect the enhanced optoplasmonic effect of the nanoparticles by means of the system of the invention or by combining the detection of such optoplasmonic effect with the analysis of the changes in the mechanical characteristics in the substrate.

Plasmonic biosensor

The present invention relates to a plasmonic biosensor system. The system includes a nano-hole array device comprising at least one nano-hole array (NHA) including at least one or a plurality of nano holes (NH), an image sensor (A3) for capturing light provided by a light source (A1) and transmitted through the nano-hole array (NHA), and at least one or a plurality of nano-particles (NP) configured to be received by the nano-holes (NH) of the nano-hole array (NHA).