The present disclosure relates to a sensor cap for an optochemical sensor for determining or monitoring at least one analyte present in a medium having a substantially cylindrical plug-in component and a sleeve-shaped outer component. The plug-in component has an optical component with a convex-shaped surface region for optimal flow, and the optical component at least partially consists of a material transparent to measuring radiation. On the surface region of the optical component is an analyte-sensitive matrix having at least one functional layer. The plug-in component and the sleeve-shaped component are designed such that the connecting region coming into contact with the medium is between the plug-in component and the sleeve-shaped outer component in the edge region of the optical component or is at a radial distance from the edge region of the optical component, and is sealed, without a gap, facing the medium.

The present disclosure relates to an optical measurement probe for the detection of measurement values correlating with a measurand of a measuring medium, including a probe housing having at least one immersion region structured to be immersed in the measuring medium, a radiation source arranged in the probe housing, a radiation receiver arranged in the probe housing, and an indicator chamber formed in the probe housing and sealed via a membrane arranged in the immersion region of the probe housing, wherein an indicator is contained in the indicator chamber, the indicator including an AIE-active substance dissolved in an indicator solution or in an indicator gel, which AIE-active substance is a substance formed from species, molecules, complexes or clusters whose luminescence efficiency is increased via formation of aggregates containing the species.

A continuous glucose monitoring system may include a hand-held monitor, a transmitter, an insulin pump, and an orthogonally redundant glucose sensor, which may comprise an optical glucose sensor and a non-optical glucose sensor. The former may be a fiber optical sensor, including a competitive glucose binding affinity assay with a glucose analog and a fluorophore-labeled glucose receptor, which is interrogated by an optical interrogating system, e.g., a stacked planar integrated optical system. The non-optical sensor may be an electrochemical sensor having a plurality of electrodes distributed along the length thereof. Proximal portions of the optical and electrochemical sensors may be housed inside the transmitter and operationally coupled with instrumentation for, e.g., receiving signals from the sensors, converting to respective glucose values, and communicating the glucose values. The sensors' distal portions may be inserted into a user's body via a single delivery needle and may be co-located inside the user's body.

The present disclosure relates to a sensor for determining measured values of a measured variable representing an analyte content in a measuring fluid, comprising a measuring probe with a probe housing that comprises an immersion region provided for immersion into the measuring fluid, and a single-layer or multi-layer membrane arranged in the immersion region, wherein the membrane comprises at least a first layer that is formed from a polymer and comprises a superhydrophobic surface that is in contact with the measuring fluid when the immersion region is immersed in the measuring fluid.

The invention relates to a sensing unit (1) comprising a housing (2) that has a first housing opening which can be oriented towards a medium (M) to be analyzed, and a second housing opening on which at least one means for detachably rigidly connecting to a sensor shaft or sensor housing are arranged, or may be arranged, on the inner and/or outer side; at least one sensor element (3) that is arranged in the housing (2) and comprises indicators and, optionally, indicator protectors, said sensor element (3) having a first side facing the first housing opening and a second side lying opposite the first housing opening; and at least one protector element (4) which is arranged in the region of the first housing opening between the at least one sensor element (3) and the medium (M) which surrounds the sensing unit (1), particularly in the region of said housing opening, such that the sensor element (3) does not come into direct contact with the medium (M).

An sensor (2) based on an optical-sensing technique measures gaseous or dissolved analytes in a measurement medium (4). The sensor has a sensor housing (6) and an optochemical sensor element (20, 220) arranged within the sensor housing. The optochemical sensor element (220) has a substrate (222), a sensing layer (224) and a barrier layer (230). The barrier layer is arranged to protect the optochemical sensor element from interfering substances (234) present in the measurement medium.

Described herein are a wearable apparatus and methods for detecting the presence of a targeted substance in a liquid. For example, the wearable apparatus can be a fingernail that detects illicit drugs in a beverage. The wearable apparatus comprises a detection layer comprising an indicator that is configured to display a signal upon the detection of an interaction with the targeted substance. In some examples, the wearable apparatus can include a lateral flow assay.

Described herein are apparatus and methods for detecting substances of abuse or other analytes in liquids. For example, the apparatus and methods described herein can be used for real-time detection of analytes, such as substances of abuse. The methods comprise providing a detection area comprising a chromatographic membrane capable of receiving the liquid and allowing for migration of the liquid, the chromatographic membrane comprising an anti-analyte antibody-particle conjugate, an analyte-conjugate protein at a test line; exposing at least the first location of the apparatus to the liquid; and determining whether an interaction between the analyte-conjugate protein and the liquid occurs to detect the presence of the analyte. The chromatographic membrane may further comprise an anti-species antibody at a control line. Specific buffers are disclosed, and these buffers may be used in the preparation of the apparatus to overcome challenges associated with miniaturization and challenges associated with exposure to beverages.

The invention relates to an optical sensor device for measuring at least two analytes. The sensor device contains at least one first dye and a second dye, wherein the dyes have an optical behaviour that depends on the respective analytes. The at least one first dye is contained in a membrane. The membrane limits a cavity. The cavity contains a buffer mixed with the second dye. A reservoir for the buffer and second dye is provided, the reservoir being in diffusive contact with the cavity. The optical behaviour of the dyes can be stimulated with excitation light, and the resulting optical behaviour can for example be detected by photodetectors making use of associated dichroic mirrors. Components of the optical sensor device may be arranged in a common housing.

The present disclose generally relates to optochemical imaging of a chemically active surface. A system that can facilitate such optochemical imaging can include an analyte-permeable membrane configured to prevent diffusion of outside contaminates into the system. The analyte permeable membrane comprising: a first surface; and a second surface opposed to the first surface configured to contact a chemically-active surface to permit diffusion of an analyte into the system from the chemically-active surface. The system also includes a measurement component coupled to the analyte-permeable membrane and configured to interact with the analyte. The interaction between the analyte and the measurement component causes a detectable change of a property of the measurement component.