Disclosed is a device for evaluating damage of fracturing fluid to reservoir and operation method thereof, the device includes a liquid storage tank, a suction tube, a chromatography device, a bracket, a receiving container and a height adjuster; the disclosure has the following beneficial effects: since different liquids pass through the porous medium at different time and speed and the silica gel particles will not expand when immersed in the liquid, a porous structure is formed by placing silica gel particles of different sizes to simulate the pore-throat structure of unconventional oil and gas reservoirs, hence removing the influence of fracturing fluid on the hydration and expansion damage of the reservoir matrix, by testing the time and flow rate of different fracturing fluids flowing through the silica gel pores, the degree of damage caused by fracturing fluids to unconventional oil and gas reservoirs is evaluated.

Described is a mixer for a liquid chromatography system. The mixer includes an inlet, an outlet, a first flow channel, and a second flow channel. The inlet receives a fluid flow to be mixed and the outlet provides the mixed fluid flow. Each of the two flow channels is coupled between the inlet and the outlet. The second flow channel includes an offset volume that delays fluid propagation through the second flow channel relative to the first flow channel. The offset volume includes a coiled channel which increases radial dispersion and decreases axial dispersion of a fluid flowing through the offset volume, thereby enabling a further reduction in periodic noise in a detector baseline signal as compared to known split flow mixers for liquid chromatography systems.

An ion suppressor includes ion exchange membranes between a pair of electrodes. Regeneration liquid channels are provided in the spaces between the electrodes and the ion exchange membranes, and an eluent channel is provided between the ion exchange membranes. Ion re-exchange in the eluent on the downstream side of the eluent channel is suppressed, thereby making it possible to improve the detection sensitivity for the ion to be measured. For example, the eluent channel has a folded structure, thereby increasing the amount of current on the downstream side of the eluent channel, and thus, the accumulation of ions is suppressed, and accordingly, ion re-exchange in the eluent can be suppressed.

A method for determining in a sample, by mass spectrometry, the amount of one or more analytes selected from the group consisting of 12,13-DiHOME, 3-hydroxybutyrate (BHBA), 3-hydroxyoctanoate, 3-methylglutarylcarnitine, 3-ureidopropionate, 7-alpha-hydroxy-4-cholesten-3-one (7-Hoca), citrate, fucose, fumarate, gamma-tocopherol, glutamate, glutarate, glycerol, glycochenodeoxycholate, glycocholate, hypoxanthine, maleate, malonate, mannose, orotate, 2,3-pyrdinedicarboxylate, ribose, serine, taurine, taurochenodeoxycholate, taurocholate, palmitoleate, linolenate, xanthine, xylitol, and combinations thereof is described. The method comprises subjecting the sample to an ionization source under conditions suitable to produce one or more ions detectable by mass spectrometry from each of the one or more analytes; measuring, by mass spectrometry, the amount of the one or more ions from each of the one or more analytes; and using the measured amount to determine the amount of each of the one or more analytes in the sample.

Disclosed are methods, systems, and computer program products for using liquid chromatography/tandem mass spectrometry (LC-MS/MS) for the analysis of endogenous biomarkers, such as 11-oxo androgens, in a sample. The 11-oxo androgens may comprise at least one of 11-hydroxyandrostendione (11OHA), 11-hydroxytestosterone (11OHT) or 11-ketotestosterone (11KT). More specifically, the methods, systems, and computer program products are described for detecting and quantifying the amount of an 11-oxo-androgen in a sample.

Disclosed is a method for determining an operating flow rate for a chromatographic column (4) in an HPLC system (1). The method comprises: measuring/calculating a pressure of the system (1) without the chromatographic column (4) for one or more flow rates; fitting a function to the flow rate(s) and corresponding pressure(s), calculating from the function and a predetermined recommended flow rate for the chromatographic column (4) a system pressure drop at the predetermined recommended flow rate. An operating flow rate is determined by summing the system pressure drop and a maximal column pressure limit, and determining a contribution of the system pressure drop to the summed pressure. If this contribution exceeds 1% an operating flow rate for the column is determined to a flow rate that corresponds to a pressure at a pressure monitor arranged before the column that is lower than the predetermined maximum column pressure limit.

A radiosynthesis system is disclosed that leverages droplet microfluidic radiosynthesis and its inherent advantages including reduction of reagent consumption and the ability to achieve high molar activity even when using low starting radioactivity. The radiosynthesis system enables the parallel synthesis of radiolabeled compounds using droplet-sized reaction volumes. In some embodiments, a single heater is used to create multiple reaction or synthesis sites. In other embodiments, separate heaters are used to create independently-controlled heating conditions at the multiple reaction or synthesis sites. In one embodiment, a four-heater setup was developed that utilizes a multi-reaction microfluidic chip and was assessed for the suitability with high-throughput radiosynthesis optimization. Replicates of several radiochemical operations including the full synthesis of various PET tracers revealed the platform to have high repeatability (e.g., consistent fluorination efficiency). The system may also be used for synthesis optimization.

A fitting includes a screw portion that is rotatable around an axis extending in one direction, an operating portion that applies a torque around the axis to the screw portion, and a rotation auxiliary member that is configured to be engageable with the operating portion. A slot extending from a first end to a second end is provided in the rotation auxiliary member, and also a first projection that protrudes outward is provided on the rotation auxiliary member. A positional relationship of the first projection is set such that an engaging force between the rotation auxiliary member and the operating portion is increased due to a change in width of the slot in a case where a force is applied to the first projection in the first rotation direction with the rotation auxiliary member engaging with the operating portion.

A device for separating one or more molecules of interest in a liquid specimen including a monolithic body defining a fractionation column. The column includes an inlet opening at a proximal end of the fractionation column; an outlet opening at a distal, opposite end of the fractionation column; a solid phase chamber positioned between the inlet opening and the outlet opening; a specimen introduction area adjacent a proximal end of the solid phase chamber; an analyte exit area adjacent a distal end of the solid phase chamber; an inlet chamber adjacent the inlet opening that tapers into the specimen introduction area; and an outlet chamber that extends from the analyte exit area to the outlet opening. A metered amount of solid phase packed within the solid phase chamber between a first porous frit and a second porous frit of the solid phase chamber.

The present disclosure discusses a method of separating a sample (e.g., pharmaceutical drug, genotoxic impurity, biomarker, and/or biological metabolite) including coating a metallic flow path of a chromatographic system; injecting the sample into the chromatographic system; flowing the sample through the chromatographic system; separating the sample; and analyzing the separated sample using mass spectroscopy. In some examples, the coating applied to the surfaces defining the flow path is non-binding with respect to the sample—and the separated sample. Consequently, the sample does not bind to the low-binding surface of the coating of the flow path. The applied coating can increase the chromatographic peak area for the sample of the chromatographic system.