Obtaining sufficient suppression effect of channel diffusion and stably transferring solution are made possible even in a piping having an extremely small inner diameter used for an analysis apparatus such as an HPLC. A piping device for an analysis apparatus includes a piping equipped with a folded shape that suppresses inner channel diffusion, and a member directly or indirectly in contact with the piping from at least one side to support the piping to suppress deformation of the folded shape.

Systems and methods are described to maintain a liquid sample segment of a sample transmitted through a transfer line from a remote sampling to an analysis system. A system, embodiment includes, but is not limited to, a sample transfer line configured to transport a liquid sample from a remote sampling system via gas pressure; a sample loop fluidically coupled with the sample transfer line, the sample loop configured to hold a sample fluid; and a backpressure chamber fluidically coupled with a gas pressure source and with the sample transfer line, the backpressure chamber configured to supply a backpressure against the liquid sample during transport through the sample transfer line.

Described is a dual mode sample manager for a liquid chromatography system. The dual mode sample manager includes a sample needle, a sample loop, a metering pump, a needle seat and first and second valves. Each valve is configurable in two valve states to enable two modes of operation. In one mode, sample acquired and stored in the sample needle is injected into a chromatography system flow and, in the other mode, sample acquired through the sample needle and stored in the sample loop is injected into the chromatography system flow. The automated switching of the sample manager between the two modes of operation avoids the need for maintaining two separate liquid chromatography systems or manual reconfiguration of a chromatography system for users desiring the capability of both modes of operation.

A first solution is supplied from a first pump. A second solution is supplied from a second pump. A flow path from the first pump and the second pump to a column is switched between a first flow path and a second flow path. In the first flow path, a first mixer is located upstream of an injection part for a sample, and the second mixer is located downstream of the injection part. In the second flow path, the first mixer and the second mixer are located upstream of the injection part. The first flow path is formed in a first mode in which the sample is diluted before introduction into the column. The second flow path is formed in a second mode in which the sample is not diluted before introduction into the column.

A compression fitting includes a nut with a threaded end for receiving a threaded tube and a receiving end for holding a plunger head; and a plunger with an inner bore for receiving a capillary tube and the plunger head for engaging a ferrule positioned within the receiving end between the plunger head and the threaded tube, the plunger slidingly engaged with the nut to force the ferrule from the nut.

A method for collecting a sample for sample analysis includes drawing a first portion of the sample into a sample storage portion of a chromatography system while the chromatography system is in a first configuration. The method further comprising switching the chromatography system to a second configuration; sealing an end of a sample pick-up needle and draining a portion of a liquid from the second tubing; switching the chromatography system to a third configuration; drawing a second portion of the sample into the sample storage portion of the chromatography system; switching the chromatography system to an injection configuration; and fluidly connecting the sample storage portion to the chromatography column and supplying the first portion of the sample and the second portion of the sample from the sample storage portion to the chromatography column.

A method for collecting a sample for sample analysis includes drawing a first portion of the sample into a sample storage portion of a chromatography system while the chromatography system is in a first configuration. The method further comprising switching the chromatography system to a second configuration; sealing an end of a sample pick-up needle and draining a portion of a liquid from the second tubing; switching the chromatography system to a third configuration; drawing a second portion of the sample into the sample storage portion of the chromatography system; switching the chromatography system to an injection configuration; and fluidly connecting the sample storage portion to the chromatography column and supplying the first portion of the sample and the second portion of the sample from the sample storage portion to the chromatography column.

Systems and methods are described to maintain a liquid sample segment of a sample transmitted through a transfer line from a remote sampling to an analysis system. A system embodiment includes, but is not limited to, a sample transfer line configured to transport a liquid sample from a remote sampling system via gas pressure; a sample loop fluidically coupled with the sample transfer line, the sample loop configured to hold a sample fluid; and a backpressure chamber fluidically coupled with a gas pressure source and with the sample transfer line, the backpressure chamber configured to supply a backpressure against the liquid sample during transport through the sample transfer line.

A sample injector is provided for a chromatography system that includes a mobile phase drive and a separation unit. The mobile phase drive is configured for driving a mobile phase through the separation unit, and the separation unit is configured for chromatographically separating compounds of a sample fluid in the mobile phase. The sample injector is configured for injecting the sample fluid into the mobile phase and comprises a needle and a handling unit configured for positioning the needle. Operating the sample injector includes providing a receptacle that includes a filtration unit configured for filtering a sample fluid comprised within the receptacle, moving the filtration unit within the receptacle in order to filter at least a portion of the sample fluid contained in the receptacle, operating the handling unit to position the needle into the receptacle, and aspirating a volume of the filtered sample fluid.

A sample injector is provided for a chromatography system that includes a mobile phase drive and a separation unit. The mobile phase drive is configured for driving a mobile phase through the separation unit, and the separation unit is configured for chromatographically separating compounds of a sample fluid in the mobile phase. The sample injector is configured for injecting the sample fluid into the mobile phase and comprises a needle and a handling unit configured for positioning the needle. Operating the sample injector includes providing a receptacle that includes a filtration unit configured for filtering a sample fluid comprised within the receptacle, moving the filtration unit within the receptacle in order to filter at least a portion of the sample fluid contained in the receptacle, operating the handling unit to position the needle into the receptacle, and aspirating a volume of the filtered sample fluid.