A liquid junction assembly for providing a flow connection between two tubular conduits. The assembly includes respective bodies configured to define elongated passages of respective first and second cross sections to receive and locate the respective tubular conduits, a plate with at least one hole therethrough of a third cross section smaller than the first and second cross sections, and a seat for the plate, defined in a face of one or both of the bodies. The bodies and the plate are assembled with the plate in the seat and the elongated passages and the hole aligned along a common axis.

A separating column for use with a filling tube to prepare for chromatography is disclosed. The separating column includes an axially movable spring stamp; and a plurality of springs coupled to the stamp. Moreover, the stamp is depressed directly into the column tube during column packing via the filling tube. Additionally, the stamp is fixed in the column tube while maintaining the packing pressure so that the springs are compressed during the packing process and press the stamp permanently and dynamically onto a chromatographic bed.

A chromatography device having a housing formed from an upper housing ultrasonically welded to a lower housing. A compression extension and a boss located inside of the housing with the media disposed between the compression extension and the boss such that a perimeter of the media is compressed between the compression extension and the boss forming a liquid impermeable seal along the perimeter after the upper housing is ultrasonically welded to the lower housing.

A particulate plug for removing a preservative from a solution, suspension, or emulsion comprising a drug is presented. The plug comprises microparticles of a hydrophobic polymer/fatty acid blend. The microparticles of hydrophobic polymer/fatty acid blend selectively absorb preservative allowing the drug to remain in solution for delivery.

A the quick extraction kit includes a column and a cap. The column has an interior space to be filled with materials for extraction and cleanup. The column has at its top an opening and a flange, and at its bottom an lower tube. The lower tube has an outlet at its bottom. The cap has a base plate, an upper tube on the base plate, and a pair of reinforcing ribs. In particular, the base plate of the cap and the flange of the column together creates a sealing joint there between by spin welding. The upper tube of the cap is in communication with the column and has an inlet. Each of the reinforcing ribs has a bottom surface bonded with the top surface of the base plate, and an inner side surface adjacent to the bottom surface and bonded with a peripheral side surface of the upper tube.

A fitting for providing a fluid connection between a capillary and a fluidic conduit of a fluidic component, wherein the fitting comprises a capillary reception configured for receiving the capillary, a force applicator configured for being operable to apply a fixing force for fixing the capillary within the fitting, a force limitation mechanism configured for limiting the fixing force being applicable by the force applicator to the capillary, a force splitter configured for splitting the fixing force into an advance force component for advancing the capillary received in the capillary reception towards the fluidic component and into a clamping force component for clamping the capillary received in the capillary reception within the fitting, and a biasing mechanism particularly arranged between the force applicator and the force splitter and configured for biasing the force splitter against the capillary.

In a preparative separation-purification system for passing a solution containing a target component through a trap column 21 to capture the target component in the column 21, and for subsequently passing an eluting solvent through the column 21 to elute the captured component and collect it in a container, an outlet aperture 27 of the column 21 has a tapered shape whose sectional area is largest on a plane facing an inner space of the column 21 and decreases in the flowing direction of the liquid. A filter 26 for preventing deposition of the target component is also provided at the boundary between the inner space of the column 21 and a passage for discharging liquid from the inner space. By this configuration, clogging of the passage at the outlet end of the column 21 due to deposition of the target component is prevented.

A vise for column, for attaching a plug to a column tube of a column for chromatography comprising the column tube and the plug to be attached to one end of the column tube, is provided. The vise comprises a column supporter configured to be able to support a part of the column for chromatography, a main body configured to be connected to the column supporter and extending from the column supporter by a predetermined distance, and a column presser configured to be supported at another end of the main body opposite to one end to which the column supporter is connected, and configured to be movable toward and away from the column supporter, and configured to be able to press the plug against the column tube.

Chromatography column components are described. One component, a chromatography plug, can include a body, the body including: a first surface; a second surface opposing the first surface; a passage through the body extending from an opening in the first surface to an opening in the second surface; and a circumferential surface extending from the first surface to the second surface; a plurality of ridges, located on the first surface, wherein each of the plurality of ridges having a first end and an opposed second end, and the first end of each of the plurality of ridges being closer to one another than the second ends of each of the plurality of ridges. In some instances, a bridge can be located between the first ends, the bridge extending into the body. A porous partition can be located on or in the plug.

The present invention relates chromatography cartridge comprising a barrel to be sealed with a cap utilizing a seal member such as an O-ring. The barrel comprises barrel lip on the circular top surface of the barrel. The cap comprises a seal holder and a space to accommodate the seal member. Then the cap is mounted on the barrel an interior contact surface of the cap will contact the barrel lip and force the barrel lip to shear inwards. The barrel lip and the contact surface will form a first cartridge seal. The barrel lip will in turn contact the seal member which will contact a seal surface of the cap and the seal holder to form a second cartridge seal.