The present invention relates to an apparatus (200) for bio-product processing. The apparatus (200) comprise a processing column (201) comprising an upper column tube (202B) releasably coupled to a lower column tube (202A). The lower column tube (202A) has a processing chamber (218) provided therein. The apparatus (200) additionally comprises an adapter (222) for moving within the processing column (201) so as to vary the volume of the processing chamber (218) within the lower column tube (202A), and a column stand (214) for supporting the adapter (222).

The present invention relates to a pre-packed chromatography cartridge (10) suitable for flash chromatography. The chromatography cartridge (10) comprises a barrel (20) having one end sealed with a cap (40), a thread (23) arranged on the outer cylindrical surface of the barrel (20) and engaged to a mating thread (43) on the inner cylindrical surface of the cap (40). The barrel is provided with at least one protrusion (24) arranged on the outer cylindrical surface and below the thread (23) in the direction from the end sealed by the cap (40). The protrusion (24) extends essentially radially outwards from the outer cylindrical surface of the barrel (20). The cap (40) is provided with a cylindrical flange (44) arranged below the thread (43) of the cap (40). A locking member (46) is arranged on the flange (44) and extends essentially radially inwards from the inner cylindrical surface of the flange (44). Together with the protrusion (24) of the barrel (20), the locking member (46) forms a mechanical connection that secures the cap (40) such that it cannot be unscrewed from the barrel (20).

The present disclosure is directed at the selection and design of columns for liquid chromatography including liquid chromatography devices and systems and corresponding methods of operation, particularly in the field of high pressure liquid chromatography (HPLC).

A device for separating one or more molecules of interest in a liquid specimen including a monolithic body defining a fractionation column. The column includes an inlet opening at a proximal end of the fractionation column; an outlet opening at a distal, opposite end of the fractionation column; a solid phase chamber positioned between the inlet opening and the outlet opening; a specimen introduction area adjacent a proximal end of the solid phase chamber; an analyte exit area adjacent a distal end of the solid phase chamber; an inlet chamber adjacent the inlet opening that tapers into the specimen introduction area; and an outlet chamber that extends from the analyte exit area to the outlet opening. A metered amount of solid phase packed within the solid phase chamber between a first porous frit and a second porous frit of the solid phase chamber.

The present invention provides a detector and method for detecting substances in complex mixtures. The detector includes a microfabricated preconcentrator, a separation column with an on-chip thermal conductivity detector, a controller for controlling flow and thermal management and a user interface. The thermal conductivity detector includes a first resistor located at an inlet of the separation column and a second resistor located at an outlet of the separation column.

Described is a chromatographic column assembly that includes an outer tube comprising a metal, a first conduit disposed within the outer tube, a second conduit disposed within the outer tube, and a first joint located between the first conduit and the second conduit. The outer tube is deformed by a first uniform radial crimp at a longitudinal location along the outer tube that surrounds the first conduit on a first side of the first joint, and a second uniform radial cramp at a longitudinal location along the outer tube that surrounds the second conduit on a second side of the first joint. The first and second uniform radial cramps form a fluid-tight seal between the first conduit and the second conduit and each have a substantially flat base region over which a diameter of the outer tube is reduced for a non-zero longitudinal length.

A sorbent tube apparatus (10) for high-pressure fluid sample analysis, the sorbent tube apparatus (10) comprising a pressurisable housing (32) having first and second fluid ports (48a, 48b) and defining a fluid chamber (34) therein; and a sorbent tube (12) mountable within the pressurisable housing (32), the sorbent tube (12) extending from one of the first and second fluid ports (48a) and spaced apart from the other of the first and second fluid ports (48b) to be in fluid communication with the fluid chamber (34), thereby enabling in use pressure equalisation between the sorbent tube (12) and fluid chamber (34). A method of analysing high-pressure fluid, an analytic probe apparatus, a further sorbent tube apparatus and method of preventing or limiting damage to a sorbent tube during high-pressure fluid sampling are also provided.

A heating apparatus for a gas chromatography column is described. The GC column heating apparatus includes a conical heater assembly comprising a heating element between an inner layer and an outer layer. The apparatus can also include optionally an outer cowl and/or an inner cowl surrounding the conical heater assembly. The conical heater assembly rapidly increases the temperature of the column by conductive heating. The selection of shape (in particular, the cone angle of a conical heater) and materials allows the GC column to adapt to expansion that occurs upon heating. A gas chromatography (GC) column heating and cooling apparatus is also described, in which the heater and outer cowl define a flowpath through which a cooling fluid can pass and cool the GC column.

The present disclosure relates to a filter. The filter includes a porous element, a compression element and a housing. At least a portion of the porous element is coated with an alkylsilyl coating. The compression element is configured to receive the porous element thereby forming an assembly. The housing has an opening formed therein. The opening is configured to receive the assembly. The assembly is retained within the opening when the assembly is received therein.

Systems, methods, and devices for detecting leaks in chromatography systems are disclosed. The leak detection system includes a sealable compartment disposed to surround at least one component of a chromatography system. The detector is in communication, e.g., fluid communication, with an interior of the sealable compartment and configured to detect the leak by various mean including the presence of liquid or the presence of vapor, or both within the sealable compartment.