There are provided techniques, including methods and systems, for chromatographically analyzing a test sample. The techniques include obtaining a sample chromatogram of the test sample with a chromatography system, the chromatography system including a detector having an adjustable response factor. The techniques also include adjusting, while obtaining the sample chromatogram, the response factor of the detector based on a compensation signal for compensating expected chromatographic artefacts to obtain an artefact-compensated sample chromatogram. The disclosed techniques allow compensating for chromatographic artefacts, which include baseline drift(s) and/or peak tailing(s), during acquisition of chromatograms.

A waveform processing assistance device includes an acquirer that acquires a plurality of waveform data obtained by an analysis of a sample, a selector that selects reference data among the waveform data, an extractor that extracts correct answer peaks and correct answer data from the reference data a determiner that determines each processing section including a correct answer peak and each parameter initial value, a waveform processor that performs waveform processing in each determined processing section based on each parameter initial value, an adjuster that generates a parameter adjustment value at which a waveform processing result obtained in each processing section matches or approximates corresponding correct answer data, and a program creator that creates a waveform processing execution program that includes an instruction to execute waveform processing using the parameter adjustment value in each processing section.

A method of performing experiments on samples may include receiving criteria defining a starting state for performing an experiment in a system including a scientific instrument; determining whether the starting state is established in the system; and, responsive to the starting state being established, allowing the experiment, that analyzes a sample using the scientific instrument, to proceed. Determining whether the starting state is established may include automated monitoring of at least one parameter for at least one data channel, and determining whether all such parameters simultaneously meet associated conditions of the criteria for specified time periods. The method may include automatically monitoring the system and re-establishing the starting state prior to performing each of one or more subsequent experiments. The method may include automatically monitoring and establishing a second starting state prior to performing each of one or more additional experiments.

Regarding a chromatogram data processing device configured to process three-dimensional chromatogram data collected on a target sample in which dimensions are made up of time, wavelength, and absorbance, and the chromatogram data processing device includes a differential spectrum generating means configured to generate a differential spectrum that represents a change in a wavelength differential coefficient, which is a differential coefficient in a wavelength direction in a predetermined wavelength range, based on the three-dimensional chromatogram data, with respect to an absorbance spectrum representing a relation of the wavelength and the absorbance at each time in an entire temporal range or a predetermined temporal range, and a determination means configured to determine whether or not one or plural other components are included in a peak of a target component, based on a temporal change in a waveform of the differential spectrum, so that the determination on whether or not a target sample includes impurities can be performed with high accuracy without the requirement of complicated computation processing.

Provided is a preparative separation chromatograph including: a chromatograph 10 having a detector 15; a fraction collector 20; a controller 34 for commanding the fraction collector to initiate a component-collecting operation with reference to a point when the rate of change in an output signal from the detector 15 exceeds a positive reference value and to discontinue the operation with reference to a point when the absolute value of the rate of change becomes smaller than that of a negative reference value after the rate of change turns negative; a storage section 31 for storing sampling-rate information which relates the value of the output signal to the time interval at which the controller determines the rate of change; and a sampling rate determiner 33 for determining the time interval for calculating the rate of change based on the sampling-rate information and actual values of the output signal.

The present application relates to a system for removal of nitrate from water. The system includes a first reactor comprising a porous oxide-derived silver electrode (OD-Ag) for electrocatalytic reduction of nitrate (NO.sub.3.sup.?) to nitrite (NO.sub.2.sup.?) and a second reactor comprising a Pd-based catalyst for catalytic reduction of nitrite (NO.sub.2.sup.?). Also disclosed is a method of removing nitrate from water.

The present application discloses method and sewer (111) for detecting faults associated with a gas chromatograph device (100) in a process plant. The gas chromatograph device (100) is associated with a database (110) configured to store a measured chromatogram, and historic chromatograms. Initially, the server receives the measured chromatogram from the database. Upon receiving the measured chromatogram, the server is configured to detect at least one real-time symptom for measured chromatogram. The real-time symptoms may be detected by comparing the historic chromatograms with predetermined configuration data to the measured chromatogram. Upon detecting the real-time symptoms, the server is configured to determine faults associated with the gas chromatograph device. The faults are determined by mapping the real-time symptoms and fault signature data received from the database. The fault signature data is generated using machine learning model trained by providing the faults and the historic gas chromatogram.

A chromatographic data system processing apparatus performs data processing based on plot data measured by a chromatograph. The chromatographic data system processing apparatus includes a virtual curve calculation portion which obtains a virtual curve based on the measured plot data, a tentative feature point acquisition portion which obtains a tentative feature point based on the obtained virtual curve, and an actual plot data feature point extraction portion which extracts an actual plot data feature point corresponding to the tentative feature point from the measured plot data.

The present disclosure provides a method for creating learning data to be used for creating a discriminator discriminating target samples having attributes different from each other.

Provided herein are methods to determine the relative amount of empty and/or partial capsids in compositions comprising recombinant adeno-associated virus (rAAV) particles. The methods utilize chromatography (e.g., size exclusion chromatography) with dual wavelength detection.