The invention relates to a method for investigating process streams comprising five or more different hydrocarbon-containing components. In the method at least one process flow line (35) is in operative connection with an online IR spectrometer (2) and an online gas chromatograph (1). The process stream passed through the process stream conduit (35) is subjected to an online characterization which comprises measurements both with the online IR spectrometer and with an online gas chromatograph. The spectral data and the chromatography data are mathematically related to one another by suitable statistical models, thus allowing training of a model used for evaluating the analytical data and for characterizing the process streams. The method according to the invention is characterized by short measurement times in the range of seconds and milliseconds and a high accuracy. The method according to the invention for investigating process streams preferably relates to investigation of process streams deriving from processes proceeding in parallel, the process streams preferably deriving from reaction spaces arranged in parallel.

The present application discloses method and sewer (111) for detecting faults associated with a gas chromatograph device (100) in a process plant. The gas chromatograph device (100) is associated with a database (110) configured to store a measured chromatogram, and historic chromatograms. Initially, the server receives the measured chromatogram from the database. Upon receiving the measured chromatogram, the server is configured to detect at least one real-time symptom for measured chromatogram. The real-time symptoms may be detected by comparing the historic chromatograms with predetermined configuration data to the measured chromatogram. Upon detecting the real-time symptoms, the server is configured to determine faults associated with the gas chromatograph device. The faults are determined by mapping the real-time symptoms and fault signature data received from the database. The fault signature data is generated using machine learning model trained by providing the faults and the historic gas chromatogram.

A system and method are disclosed for analyzing samples, which includes a spectrometry system for detecting components of a sample; a gas chromatography column for separating the components of a sample; a first sample unit for receiving a first sample from a sample source; and a second sample unit for receiving a second sample from a sample source. Each sample loop unit allows independent processing of samples in preparation for analysis.

The present invention relates to method and an apparatus for quantitatively analyzing a gaseous process stream, in particular a stream from a process for producing ethylene carbonate and/or ethylene glycol, in particular where such stream comprises gaseous organic iodides.

A sampling system for collecting periodic composite and/or non-composite samples of vaporized gas during a transfer process from a vaporizer of a cryogenic hydrocarbon liquid including 1) a direct sample pathway to a gas analyzer for instantaneous, real-time vaporized gas analysis, 2) a speed loop pathway for directly collecting fresh vaporized gas samples for subsequent analysis, and 3) a composite sample pathway including a pressurized sample accumulator for collecting a plurality periodically obtained samples of a select volume during the transfer process to create a composite sample of the vaporized gas.

The disclosure features methods that include obtaining a vibrational spectrum of a solution in a biological manufacturing system, analyzing the vibrational spectrum using a first chemometrics model to determine a value of a first quality attribute associated with the solution, analyzing the vibrational spectrum using a second chemometrics model to determine a value of a second quality attribute associated with the solution, and adjusting at least one parameter of a purification unit of the biological manufacturing system based on at least one of the values of the first and second quality attributes.

A system and method are disclosed for analyzing samples, which includes a spectrometry system for detecting components of a sample; a gas chromatography column for separating the components of a sample; a first sample unit for receiving a first sample from a sample source; and a second sample unit for receiving a second sample from a sample source. Each sample loop unit allows independent processing of samples in preparation for analysis.

The present invention relates to methods for determining the change in concentration of a substance in solution over time by continuously monitoring in real time. In particular, the present invention relates to methods for continuously monitoring the concentration of compounds during the manufacturing process of biomolecules.

In one aspect, disclosed herein is a method for determining sulfate concentration in a sample, comprising: a) providing a liquid sample comprising urea and at least one impurity; b) concentrating the liquid sample under conditions effective to reduce the liquid volume; c) forming a dilute sample solution by diluting the concentrated liquid sample of step b) in water; and d) analyzing the dilute sample solution of step c) with ion chromatography to determine if a concentration of sulfate is present in the provided liquid sample of step a); wherein the analyzing of step d) is capable of determining the presence of a sulfate concentration present in an amount less than about 1 ppm.

The present disclosure provides an apparatus and method for producing a policosanol having a specific chromatographic fingerprint. The apparatus of the present disclosure has a feed tank and receiving tanks which are connected to a vacuum system. The method of the present disclosure is carried out by a high vacuum rectification process and includes: firstly, feeding a saponified crude alkanol into a melting tank in which the material is melted and then flows into the feed tank, and then injecting the material into a rectifying still using a delivery pump, followed by first rectification under vacuum condition and sequential collection of fractions at different phases from the tower top and stillage residue from the tower bottom; and after the completion of the rectification of the first batch crude product, carrying out second feeding on the basis of consistent vacuum in the feed tank and the rectifying tower.