A method for calibrating an imager of a reagent analyzer, comprises positioning a dry reagent pad at a first read position in a field of view of the imager, the first read position illuminated by an illumination source with a first intensity, detecting a reference optical signal by the imager, indicative of a first reflectance value of the dry reagent pad at the first read position, positioning the dry reagent pad at a second read position, the second read position illuminated with a second intensity different from the first intensity, detecting a first optical signal by the imager, indicative of a second reflectance value of the dry reagent pad at the second read position, and calculating, by a processor, a calibration factor for the dry reagent pad at the second read position based on a difference between the reference optical signal and the first optical signal.

A method and automated apparatus for rapid non-invasive detection of a microbial agent in a test sample is described herein. The apparatus may include one or more means for automated loading, automated transfer and/or automated unloading of a specimen container. The apparatus also includes a detection system for receiving a detection container, e.g., container or vial, containing a biological sample and culture media. The detection system may also include one or more heated sources, holding structures or racks, and/or a detection unit for monitoring and/or interrogating the specimen container to detect whether the container is positive for the presence of a microbial agent therein. In other embodiment, the automated instrument may include one or more, bar code readers, scanners, cameras, and/or weighing stations to aid in scanning, reading, imaging and weighing of specimen containers within the system.

An apparatus comprising a magnetic assembly and methods for operating the apparatus are provided. The magnetic assembly may be used to manipulate molecules in a liquid preparation, for example to isolate or separate the molecules from the liquid. The magnetic assembly may be used to wash and/or isolate nucleic acid molecules of interest from a liquid preparation.

A method for calibrating an imager of a reagent analyzer, comprises positioning a dry reagent pad at a first read position in a field of view of the imager, the first read position illuminated by an illumination source with a first intensity, detecting a reference optical signal by the imager, indicative of a first reflectance value of the dry reagent pad at the first read position, positioning the dry reagent pad at a second read position, the second read position illuminated with a second intensity different from the first intensity, detecting a first optical signal by the imager, indicative of a second reflectance value of the dry reagent pad at the second read position, and calculating, by a processor, a calibration factor for the dry reagent pad at the second read position based on a difference between the reference optical signal and the first optical signal.

This invention relates to a cartridge assembly tray for conducting automated biochemical tests, such as immunoassay tests. The tray comprises a base member, a hinged frame and a locking mechanism. The base member includes a plurality of slots within the base member. Each of the plurality of slots is to receive a test cartridge. The hinged frame is coupled to the base member. The hinged frame is capable to rotate to an opened position or a closed position. The hinged frame includes a horizontal push bar configured to apply a downward force to test cartridges received in the plurality of slots when the hinged frame is in the closed position. The locking mechanism is to lock the hinged frame in the closed position when the hinged frame rotates to the closed position.

A milking system with a milking device, a milk line, and a sampling and analysis device to sample and analyse the milk are disclosed. The sampling and analysis device includes a control unit, a tape wound on a tape reel, and including a base material with a series of reagent pads arranged to provide a detectable response in the presence of a substance in the sample, a tape mover to move and unwind the tape, a dosing device to provide a part of the sample onto one of the reagent pads, and an optical sensor device to detect optical radiation from said reagent pad with said sample, and to analyse the detected optical radiation to provide an indication of a presence or concentration of said substance. The dosing device includes a displaceable nozzle with a supply line for supplying the sample to the nozzle. The nozzle is arranged for supplying the sample upwardly to the reagent pad. The dosing device further includes a nozzle mover to move the displaceable nozzle towards and away from the tape, and an overflow device, or cup, including a wall that surrounds the nozzle. An overflow space is provided between the wall and the nozzle, and further includes a discharge. The overflow device can collect excess fluid, both when sampling and certainly when flushing. Herein, gravity helps in collecting fluid, but importantly, also in supplying the sample, since the sample droplet cannot break off the nozzle unexpectedly.

A signal processing system used for GMR-based detection of a target analyte in a sample under test, comprising: a measurement circuit configuration unit configured to build a GMR sensor measurement circuit by routing in at least one GMR sensor, and to build a reference resistor measurement circuit by routing in at least one reference resistor; a magnetic field excitation unit configured to apply an AC magnetic field of frequency ω.sub.2 to the at least one GMR sensor; a carrier signal applying unit configured to apply a carrier signal of frequency ω.sub.1 to the GMR sensor measurement circuit, and apply carrier signals of frequency ω.sub.1, ω.sub.1+ω.sub.2, and ω.sub.1−ω.sub.2 to the reference resistor measurement circuit; a measurement signal pick-up unit coupled to the measurement circuits, configured to collect reference resistor measurement signals from the reference resistor measurement circuit and GMR sensor measurement signals from the GMR sensor measurement circuit; and a phase sensitive solution unit coupled to the measurement signal pick-up unit, configured to analytically solve for resistance change of the at least one GMR sensor based on both the reference resistor measurement signals from the reference resistor measurement circuit and the GMR sensor measurement signals from the GMR sensor measurement circuit.

A microfluid thromboelastometry instrument for analyzing a viscosity of a sample fluid is provided. The microfluid thromboelastometry instrument includes a cartridge for measuring changes in the viscosity of a fluid, the cartridge includes an inlet and an outlet, wherein a flow of the fluid is provided through the cartridge between the inlet and the outlet. The cartridge includes at least one micro-pillar having at least one first position, the at least one micro-pillar is capable of bending with a fluid flow, and an amount of bending increases as the viscosity of the fluid increasing and restores to the at least one first position of the at least one micro-pillars in response to viscosity decrease of the fluid. The micro-pillar is fixed to the surface of the cartridge from the root and has a free distal extremity. A displacement of the micro-pillar distal extremity relative to the micro-pillar root is monitored.

The present invention involves a fill needle system for aseptically dispensing a pharmaceutical fluid in an aseptic chamber comprises a fill needle tubing in fluid communication with a pharmaceutical fluid source via flexible tubing and extending through a fill needle hub; a fill needle dispensing tip disposed at a dispensing end of the fill needle tubing; a fill needle sheath shaped and arranged to removably mate with and seal aseptically to the fill needle hub to form an aseptically sealed volume enclosing the dispensing tip; and a fluid pressure pulse induction system disposed and configured to compress the flexible tubing in order to dislodge droplets of pharmaceutical fluid retained on the dispensing tip after halting dispensing of the pharmaceutical fluid. An associated method of dispensing pharmaceutical fluid comprises operating the fluid pressure pulse induction system to dislodge the droplets. The system may comprise a controller for automatically controlling the dispensing and droplet dislodging.

Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.