The present invention relates to a cancer diagnostic apparatus for checking a cancer incidence by allowing an antibody (captured antibody), which reacts with an rpS3 (ribosomal protein S3; antigen) capable of checking a phenomenon of a cancer, to react with the rpS3, and performing concentration measurement after extracting an emission signal of the reacted antigen (rpS3), and a cancer diagnostic system using the cancer diagnostic apparatus. The cancer diagnostic system includes: the cancer diagnostic apparatus for irradiating an ultraviolet ray (UV) from a bottom of a bio-chip provided with an antibody reacting with an antigen (ribosomal protein S3; rpS3), making an image from a visible ray obtained from the ultraviolet ray, which is converted by the antigen and the antibody bound to each other while passing through the bio-chip, and extracting only a specific frequency color from the visible ray to generate cancer diagnosis information; and a user terminal.

A cell capture system including an array, an inlet manifold, and an outlet manifold. The array includes a plurality of parallel pores, each pore including a chamber and a pore channel, an inlet channel fluidly connected to the chambers of the pores; an outlet channel fluidly connected to the pore channels of the pores. The inlet manifold is fluidly connected to the inlet channel, and the outlet channel is fluidly connected to the outlet channel. A cell removal tool is also disclosed, wherein the cell removal tool is configured to remove a captured cell from a pore chamber.

A system for fluorescence activated cell sorting includes at least two excitation lasers having different orientations relative to an objective such that light from the at least two lasers passes through the objective and intersects a fluidic channel at different positions within an interrogation region. The fluidic channel directs a flow of a plurality of fluorescently labeled particles through the interrogation region. The system further includes at least one detector and at least one optical element that directs light emitted from the plurality of fluorescently labeled particles and transmitted through the objective to the at least one detector. The system may further include optics for generating and detecting side and forward scattered light. Methods for operating example systems to collect fluorescent, side scattered and forward scattered light from a plurality of particles are also described herein.

The present invention generally concerns an automated system capable of performing quantitative PCR (qPCR) analysis of a nucleic acid present in a biological sample together with preparation of a sequencing-ready nucleic acid library from the sample, either simultaneously or sequentially. In a further aspect, the present invention also provides a method for performing qPCR of a nucleic acid present in a biological sample together with simultaneous of sequential preparation of a sequencing-ready nucleic acid library from the sample. Finally, the present invention also provides removable cartridges for use in the automated systems and methods according to the invention.

A method of making at least a portion of at least one microfluidic actuator having a flexible diaphragm portion and an opposite surface portion, the diaphragm and opposite surface each having opposed faces, at least one of the faces comprising surface-activated PDMS, and the opposed faces being arranged such that when the opposed faces contact each other, they form a fluidic seal, including performing repeated make-and-break-contact protocol on the contacting opposed faces until the tendency for permanent bonds to form between the contacting faces has been neutralized, thereby enabling the diaphragm portion to perform actuated movements to engage and disengage with the opposite surface portion, without the diaphragm sticking to the opposite surface portion.

Systems, methods, and devices for discretizing and analyzing fluidic samples are provided. In one aspect, a microfluidic array for discretizing a fluidic sample comprises one or more flow channels and a plurality of fluidic compartments in fluidic communication with the one or more flow channels. In another aspect, a system for discretizing and analyzing fluidic samples comprises a rotor assembly shaped to receive a microfluidic device.

An analysis device includes a guide-in section, a piercing member, an airtight member, a gas introduction member, and a measurement member. The guide-in section is configured to guide a rectangular block shaped analysis kit containing a sample. The piercing member pierces a sealing film at an upper face of a liquid reservoir formed in the analysis kit. The airtight member forms an airtight space against the analysis kit at the periphery of a location pierced by the piercing member. The gas introduction member introduces gas into the airtight space. The measurement member measures a component present in the sample in the analysis kit guided into the guide-in section.

This disclosure provides a gene chip comprising a substrate and at least one positioning device fixed on an upper surface of the substrate, wherein the at least one positioning device is provided with a receiving cavity for receiving a bead, the receiving cavity being arranged on a surface of the at least one positioning device facing away from the substrate, and a cross-sectional area of the receiving cavity is gradually decreased in a direction toward the upper surface of the substrate. This disclosure further provides a gene detection device comprising the gene chip.

A detection chip and a detection system are provided. The detection chip includes a sample adding opening and at least one detection branch structure, each of the at least one detection branch structure includes a detection portion, the detection portion includes a detection groove and a reaction reagent, the detection groove is in connection with the sample adding opening, the reaction reagent is contained in the detection groove, and the detection portion is configured to allow optical detection to be performed on the reaction reagent in the detection groove.