An apparatus (1) for dissolution testing comprises a tank (2) having a circular cylindrical outer body portion (21) with a transparent side wall and a circular cylindrical inner body portion (22) with a transparent side wall, wherein the inner body portion (22) is coaxially arranged with respect to the outer body portion (21) such that an outer interior (23) having a ring-shaped cross section is defined between the outer body portion (21) and the inner body portion (22) and an inner interior (24) having a circular cross section is defined inside the inner body portion. The apparatus (1) further comprises a plurality of dissolution vessels (4) arranged in the outer interior (23) of the tank and a heater assembly being arranged to heat a test media in the vessels (4) to a predefined temperature. The apparatus (1) according to the invention allows for a comparably precise monitoring of vessels (4) inside the tank (2) and/or an appropriate manipulation of the vessels (4) inside the tank (2).

An automatic filter changer that automatically inserts and removes a filter from a fluidic path. Filters are introduced into the automatic filter changer in stacks. The lead filter and each stack is removed from its respective stack one by one by a filter separator. The separated filters are deposited onto a shuttle plate which moves the filters into their respective fluidic paths. Fluid couplers connect to each filter to complete their respective fluidic paths and allow fluids to be filtered before sampling. Once collection of the samples is complete, the filters are removed from the fluidic path and discarded or saved for reuse. The shuttle path is returned to its original position to receive new filters to repeat the process again. A graphic user interface is provided to allow the user to program a specific set of instructions to automate the entire process.

Embodiments of the present invention provide an apparatus and method for determining whether a dosage unit of a pharmaceutical drug disintegrates in an immersion fluid of a disintegration tester within a prescribed time limit and to record and transmit to human-accessible output devices the times required. In one implementation, the apparatus comprises a computer system, a motion sensor, a capture device, a fastener for attaching the capture device and motion sensor to the reciprocating arm of the disintegration tester, and one or more data communications interfaces to carry commands and data between the computer system, the motion sensor and the capture device.

A device suitable for measuring or quantifying the permeation or diffusion of one or more substances through a membrane, said device including a housing at least part of which is configured to form a first chamber or cell capable of holding a fluid or liquid in use, and a membrane support means to hold or locate at least one membrane in use adjacent to said first chamber or cell, wherein the first chamber or cell includes one or more windows or orifices through which ultraviolet (UV), visible (VIS) and/or infrared (IR) electromagnetic radiation can pass.

Dissolving activity analyzer including an integrating cavity comprising a reflective inner wall or walls, and configured to receive a cuvette containing liquid sample. The integrating cavity comprises a light inlet port and a light outlet port, the light inlet port being configured to receive light from a light source and the light outlet port being configured to deliver light to a spectrometer. The dissolving activity analyzer is configured to operate in a diffusely reflecting mode in which light from the light source follows a light path from the inlet port into the integrating cavity, is incident onto the reflective inner wall or walls and is diffusely reflected, such that the light from the light source irradiates the liquid sample before being transmitted through the light outlet port and received by the spectrometer to provide an absorbance spectrum of the liquid or liquid matrix contained in the liquid sample.