A rack to be suspended from a support structure includes a hook portion, an upright portion, and a shelf. The hook portion defines a cavity configured to receive an upper edge of a wall of the support structure therein. The upright wall is connected to and extends from the hook portion. The shelf is connected to the upright wall at a location spaced apart from the hook portion along a height of the upright wall. The shelf projects outward from the upright wall to a distal edge of the shelf that is spaced apart from the upright wall. The shelf defines a plurality of slots through the thickness of the shelf. The slots are open along the distal edge and are configured to accommodate one or more of multiple reclosable container caps or multiple tubes connected to the reclosable container caps.

The present invention describes an integrated incubator and image capture module that regulates the incubator atmosphere and obtains high-resolution digital images of sample specimens. The incubator has a cabinet type enclosure that enables the provision of a controlled environment to the contents of the incubator by having at least three ports on one face of the cabinet for the passage of sample containers. Additionally, an image capture module is located immediately adjacent to the incubator. In this regard, using at least three separate access/egress points for the sample containers streamlines operation of the system and enhances preservation of the incubator environment. Furthermore, locating the image capture module directly adjacent to the incubator reduces the amount of time a sample container is exposed to the external environment, thereby reducing the extent to which samples are exposed to potential contaminants and reducing the exchange of the lab and ambient atmospheres.

A method for reconstituting a lyophilized reagent contained within a reagent well comprises the steps of drawing a diluent into a pipette tip attached to an automated pipettor and dispensing the diluent into the reagent well containing the lyophilized reagent. The reagent well has an internal side wall, a bottom wall, and an open upper end and includes one or more retention features disposed about the periphery of the internal side wall and defining a central opening into the well that permits passage of the pipette tip into the reagent well. The one or more retention features are integrally formed with the internal side wall, and each of the one or more retention features extends over a portion of the lyophilized reagent, thereby retaining the lyophilized reagent within the reagent well.

A rack for a diagnostic robot with at least one support for at least one container; at least one gas-outlet to supply the at least one container with a gas at a predefined but individually adjustable pressure level; a first gas pump to generate a gas at a predefined super-atmospheric pressure level; a second gas pump to generate a gas at a pre-defined sub-atmospheric pressure level; a first tubing system attached to the first gas pump and holding the gas generated by the first gas pump; a second tubing system attached to the second gas pump and holding the gas generated by the second gas pump; and at least one tube bridge, wherein one end of the bridge connects via a first valve into the first tubing system and the other end of the bridge connects via a second valve into the second tubing system, and wherein the at least one gas-outlet is connected to the center of the bridge.

A system and method for automated single cell capture and processing is described, where the system includes a deck supporting and positioning a set of sample processing elements; a gantry for actuating tools for interactions with the set of sample processing elements supported by the deck; and a base supporting various processing subsystems and a control subsystems in communication with the processing subsystems. The system can automatically execute workflows associated with single cell processing, including mRNA capture, cDNA synthesis, protein-associated assays, and library preparation, for next generation sequencing.

A container for receiving vessels for use in an automated analyzer is presented. The container comprises a wall assembly including a first wall and a second wall. The wall assembly forms a receptacle for receiving a vessel having one or more covers or lids. At least one of the first and second walls moves to provide a first open configuration for receiving the vessel and a second closed configuration. The container further comprises an actuator configured to translate the vessel from a first position after being received in the container to a second position and the wall assembly in the second closed configuration is positioned so that at least one engaging element attached to the wall assembly engages with the covers or lids of the vessel to open the covers or lids while the vessel is being translated by the actuator from the first position to the second position.

A system and method for automated single cell capture and processing is described, where the system includes a deck supporting and positioning a set of sample processing elements; a gantry for actuating tools for interactions with the set of sample processing elements supported by the deck; and a base supporting various processing subsystems and a control subsystems in communication with the processing subsystems. The system can automatically execute workflows associated with single cell processing, including mRNA capture, cDNA synthesis, protein-associated assays, and library preparation, for next generation sequencing.

A system and method for automated single cell capture and processing is described, where the system includes a deck supporting and positioning a set of sample processing elements; a gantry for actuating tools for interactions with the set of sample processing elements supported by the deck; and a base supporting various processing subsystems and a control subsystems in communication with the processing subsystems. The system can automatically execute workflows associated with single cell processing, including mRNA capture, cDNA synthesis, protein-associated assays, and library preparation, for next generation sequencing.

A rack to be suspended from a support structure includes a hook portion, an upright portion, and a shelf. The hook portion defines a cavity configured to receive an upper edge of a wall of the support structure therein. The upright wall is connected to and extends from the hook portion. The shelf is connected to the upright wall at a location spaced apart from the hook portion along a height of the upright wall. The shelf projects outward from the upright wall to a distal edge of the shelf that is spaced apart from the upright wall. The shelf defines a plurality of slots through the thickness of the shelf. The slots are open along the distal edge and are configured to accommodate one or more of multiple reclosable container caps or multiple tubes connected to the reclosable container caps.

Automated systems and methods for the quantitative collection and extraction of a fecal sample, the system including: a primary loading module configured to receive a plurality of primary stool specimen containers, and a secondary loading module configured to receive a plurality of secondary extraction tubes, each with a collection wand; a robotic arm for loading stool on the wand and inserting the stool-loaded wand into the extraction tube; a quality control module configured to assess and confirm whether loading of the collection wand meets a preset acceptable tolerance and if so, assisting with positioning of the robotic arm for accurate insertion of the stool loaded wand into the selected extraction tube; an exhaust module; and executable software loaded into the system and in communication with a database that pairs the primary stool specimen container with a corresponding secondary extraction tube(s).