The current invention relates to the method to detect early stage pre-symptom cancer with enhanced accuracy. The claimed methods use anti-tumor agent to cause lysis of any existing cancer cells in a person, and causing release of genetic material from the lysed cancer cells into the blood stream of the person. The claimed methods further utilize a PCR method to amplify cancer gene in released generic material from a blood plasma sample of the person. The claimed methods further perform genetic sequencing on the blood plasma sample after PCR to identify existence of the cancer genes, thereby confirming existence of cancer.

Devices, systems and methods including a sonicator for sample preparation are provided. A sonicator may be used to mix, resuspend, aerosolize, disperse, disintegrate, or de-gas a solution. A sonicator may be used to disrupt a cell, such as a pathogen cell in a sample. Sample preparation may include exposing pathogen-identifying material by sonication to detect, identify, or measure pathogens. A sonicator may transfer ultrasonic energy to the sample solution by contacting its tip to an exterior wall of a vessel containing the sample. Multipurpose devices including a sonicator also include further components for additional actions and assays. Devices, and systems comprising such devices, may communicate with a laboratory or other devices in a system for sample assay and analysis. Methods utilizing such devices and systems are provided. The improved sample preparation devices, systems and methods are useful for analyzing samples, e.g. for diagnosing patients suffering from infection by pathogens.

The automatic analysis device 100 is provided with: a specimen dispensing mechanism 101 that dispenses subject blood plasma and/or normal blood plasma to be added to correct the coagulation time of the subject blood plasma, into a plurality of specimen containers 103; reaction containers 104 that contain the subject blood plasma and/or the normal blood plasma; a reagent dispensing mechanism 106 that dispenses a reagent into the reaction containers 104; and a detecting unit 113 which applies light from a light source 115 to the subject blood plasma and/or the normal blood plasma to which the reagent is added in the reaction containers 104, and which measures the coagulation time on the basis of the obtained scattered light and/or transmitted light.

An autosampler system for handling liquids having nanoparticles is described. A system embodiment includes, but is not limited to, a sample arm assembly; an ultrasonic bath accessible by a sample probe of the sample arm assembly; and an ultrasonic control system operably coupled with the ultrasonic bath, the ultrasonic control system configured to manipulate an ultrasonic condition of a liquid held by the ultrasonic bath.

Devices, systems, and methods for detecting molecules of interest within a collected sample are described herein. In certain embodiments, self-contained sample analysis systems are disclosed, which include a reusable reader component, a disposable cartridge component, and a disposable sample collection component. The reader component may communicate with a remote computing device for the digital transmission of test protocols and test results. In various disclosed embodiments, the systems, components, and methods are configured to identify the presence, absence, and/or quantity of particular nucleic acids, proteins, or other analytes of interest, for example, in order to test for the presence of one or more pathogens or contaminants in a sample.

Devices, systems and methods including a sonicator for sample preparation are provided. A sonicator may be used to mix, resuspend, aerosolize, disperse, disintegrate, or de-gas a solution. A sonicator may be used to disrupt a cell, such as a pathogen cell in a sample. Sample preparation may include exposing pathogen-identifying material by sonication to detect, identify, or measure pathogens. A sonicator may transfer ultrasonic energy to the sample solution by contacting its tip to an exterior wall of a vessel containing the sample. Multipurpose devices including a sonicator also include further components for additional actions and assays. Devices, and systems comprising such devices, may communicate with a laboratory or other devices in a system for sample assay and analysis. Methods utilizing such devices and systems are provided. The improved sample preparation devices, systems and methods are useful for analyzing samples, e.g. for diagnosing patients suffering from infection by pathogens.

Devices, systems and methods including a sonicator for sample preparation are provided. A sonicator may be used to mix, resuspend, aerosolize, disperse, disintegrate, or de-gas a solution. A sonicator may be used to disrupt a cell, such as a pathogen cell in a sample. Sample preparation may include exposing pathogen-identifying material by sonication to detect, identify, or measure pathogens. A sonicator may transfer ultrasonic energy to the sample solution by contacting its tip to an exterior wall of a vessel containing the sample. Multipurpose devices including a sonicator also include further components for additional actions and assays. Devices, and systems comprising such devices, may communicate with a laboratory or other devices in a system for sample assay and analysis. Methods utilizing such devices and systems are provided. The improved sample preparation devices, systems and methods are useful for analyzing samples, e.g. for diagnosing patients suffering from infection by pathogens.

An automatic chemical analyzer, maintenance kit, and maintenance method capable of, even in a case where a problem of the automatic chemical analyzer occurs, clarifying a cause of the problem in a user site and coping with the problem without collecting a device or a component. The automatic chemical analyzer maintenance kit is connectable to an automatic chemical analyzer including a reaction vessel for accommodating at least a pipetted specimen and a reagent, and a stirring mechanism including a piezoelectric element that irradiates the reaction vessel with ultrasonic waves. The piezoelectric element includes a plurality of divided electrodes. The automatic chemical analyzer maintenance kit measures, for each of the divided electrodes, an absolute value of an impedance of the piezoelectric element and a phase difference between a voltage applied to the divided electrode and a current, and determines if there is an abnormality an electrode based on a measurement result.

According to the invention, a robotic arm is used to transport a separation device integrated with a liquid handling system that uses a single probe or disposable pipette tip for liquid handling purposes. A biological fluid sample and necessary reagents are transferred into a separation device by the liquid handling system under metrological control. Thereafter, the content in the separation device is exposed to ultrasonic power to achieve homogeneity and accelerate protein denaturization or molecular interaction. Then, a clean sample extract with complete removal of unwanted proteins and other impurities is obtained by filtration and is loaded into a sample loop and injected for analysis by a binary pump system with various types of chromatographic detectors, for example, a mass spectrometer.

Devices, systems, and methods for detecting molecules of interest within a collected sample are described herein. In certain embodiments, self-contained sample analysis systems are disclosed, which include a reusable reader component, a disposable cartridge component, and a disposable sample collection component. The reader component may communicate with a remote computing device for the digital transmission of test protocols and test results. In various disclosed embodiments, the systems, components, and methods are configured to identify the presence, absence, and/or quantity of particular nucleic acids, proteins, or other analytes of interest, for example, in order to test for the presence of one or more pathogens or contaminants in a sample.