G01N35/00693

DILUENT PREPARATION MODULE
20220155330 · 2022-05-19 ·

Certain types of automated medical analysis equipment are used to analyze blood or other fluids. The equipment may thus use various diluents or reagents that allow the blood or other fluids to be run through the analysis equipment for analysis and data collection. Disclosed is a diluent preparation module that combines purified water and reagent concentrate for use by this equipment. Also disclosed is a diluent preparation unit that combines more than one diluent preparation modules for redundancy and back-up purposes. Also disclosed are systems for supplying the Diluent prepared by the diluent preparation module or diluent preparation unit to one or more analytic instruments.

Methods and systems of performing an assay

Methods and systems of performing an assay. A system for performing an assay includes an enclosure defining a temperature-controlled space. An imaging system, an actuator and a dispenser are disposed within the space. The actuator receives a well plate having wells. The actuator is to move the well plate relative to the imaging system to enable the imaging system to obtain image data of one of the wells. The dispenser includes a pump, an outlet and a reservoir holder to receive a reservoir containing a compound. The pump is to be fluidly coupled to the reservoir and an outlet. The pump is to pump the compound from the reservoir through the outlet into one of the wells. The system also includes a controller. The controller is to cause the dispenser to dispense the compound into the first one of the wells while the imaging system obtains the image data.

A METHOD AND A SYSTEM FOR AUTOMATED HANDLING OF PIPETTES
20220143593 · 2022-05-12 ·

The disclosure relates to a method and a system for automated handling of a pipette. The system may include an identifying device for identifying the pipette, a robot being configured to perform a handling operation on the pipette, and a control unit. The control unit may be configured to obtain data related to the pipette from a database. The control unit may also be configured to obtain data from one or more of the identifying device and the robot.

MULTIVARIATE PROCESS CHART TO CONTROL A PROCESS TO PRODUCE A CHEMICAL, PHARMACEUTICAL, BIOPHARMACEUTICAL AND/OR BIOLOGICAL PRODUCT

Aspects of the application relate to methods, a computer program and a process control device. According to one aspect, a computer-implemented method for determining a multivariate process chart is provided. The multivariate process chart is to be used to control a process to produce a chemical, pharmaceutical, biopharmaceutical and/or biological product. The multivariate process chart includes a first trajectory, an upper limit for the first trajectory and a lower limit for the first trajectory.

System and method for characterizing, monitoring, and detecting bioaerosol presence and movement in an indoor environment

One variation of a method includes, during a calibration period: triggering collection of an initial bioaerosol sample by an air sampler located in an environment; and triggering dispensation of a tracer test load by a dispenser located in the environment; accessing a detected barcode level of a barcode detected in the initial bioaerosol sample; accessing a true barcode level of the barcode contained in the tracer test load; and deriving a calibration factor for the environment based on a difference between the detected barcode level and the true barcode level. The method further includes, during a live period succeeding the calibration period: triggering collection of a first bioaerosol sample by the air sampler; accessing a detected pathogen level of a pathogen detected in the first bioaerosol sample; and interpreting a predicted pathogen level of the pathogen in the environment based on the detected pathogen level and the calibration factor.

Sample measuring method and sample measurement device

A sample measuring method of optically measuring a sample housed in a container in a sample measurement device, the method including: loading the container such that the container is shielded from light; starting to read information regarding a measurement to be performed on the sample in response to the loading the container; and measuring the sample based on the read information.

CALIBRATION CURVE GENERATION METHOD, AUTONOMOUS ANALYSIS DEVICE, AND CALIBRATION CURVE GENERATION PROGRAM
20230258669 · 2023-08-17 ·

An object of the present invention is to suppress time and effort into generating a calibration curve while ensuring accuracy of the calibration curve in an analysis step of generating the calibration curve by using two or more standard solutions (two or more concentrations). A calibration curve generation method according to the present invention includes acquiring time course data by irradiating a mixed reaction liquid obtained by mixing one standard solution containing a component to be measured having a concentration other than a zero concentration and a reagent reacting with the component to be measured with light and measuring a turbidity change over time of the mixed reaction liquid, extracting pieces of light amount data in a plurality of different times from a fitting line obtained by complementing discrete portions of the time course data, and generating the calibration curve indicating a relationship between the plurality of pieces of light amount data and a plurality of concentrations by converting the plurality of different times into the plurality of concentrations of the component to be measured (FIG. 1).

METHOD FOR CALIBRATING A PHOTOMETRIC ANALYZER
20220136961 · 2022-05-05 ·

The present disclosure discloses a method for calibrating a photometric analyzer which is designed to determine the silicate content of an analyte, comprising the steps of: detecting a first measurement point, with the steps of adding a first reagent to a sample of a first calibration standard, adding a second reagent to this sample, adding a third reagent to this sample; detecting a second measurement point, wherein the second measurement point differs from the first measurement point, with the steps of adding the second reagent to a sample of a second calibration standard, adding the first reagent to this sample, adding a third reagent to this sample; determining the zero point and the slope of the calibration line using the first and second measurement points.

SYSTEMS AND METHODS FOR TRACKING VIEWING POSITION DURING SAMPLE ANALYSIS
20230305284 · 2023-09-28 ·

A sample analyzer is configured to obtain first and second stage position data. The first stage position data indicates a first position of a movable stage in a first dimension, and the second stage position data indicates a second position of the movable stage in a second (perpendicular) dimension. The sample analyzer is configured to, based on the first and second stage position data, determine a viewing position of one or more viewing or imaging optics relative to the movable stage. The sample analyzer is configured to display a vessel map, which comprises a visual representation of a sample vessel associated with the movable stage. The sample analyzer is configured to display a viewing position marker overlaid on the vessel map. The viewing position marker indicates the viewing position of the one or more viewing or imaging optics relative to the sample vessel as represented by the vessel map.

System and method for analyzing a sample with a dynamic recipe based on iterative experimentation and feedback

A system for analyzing one or more samples includes a sample analysis sub-system configured to perform one or more measurements on the one or more samples. The system further includes a controller configured to: receive design of experiment (DoE) data for performing the one or more measurements on the one or more samples; determine rankings for a set of target parameters; generate a recipe for performing the one or more measurements on the one or more samples based on the DoE data and the rankings of the set of target parameters; determine run parameters based on the recipe; perform the one or more measurements on the one or more samples, via the sample analysis sub-system, according to the recipe; and adjust the run parameters based on output data associated with performing the one or more measurements on the one or more samples.