A mobile, self contained molecular diagnostics system is provided with a microfluidic chip, detection apparatus and an integrated or wireless control interface and imager. The system provides automated sample preparation and rapid optical detection of multianalyte nucleic acids and proteins. On chip PCR may be performed to improve the optical fluorescence signal for nucleic acid detections. Plasmonic protein detection is performed using a dark field smartphone microscope. Dark field illumination is based on an evanescent field generated by LED total internal reflection. The smartphone element may also be used as an interface to control the detection apparatus, acquire images, process data and for wireless communications with remote computers. The handheld automated system has low power requirements and is particularly suited for point of care and on demand diagnostics in resource limited settings.

Disclosed herein are systems, devices, and methods related to a determination of whether an asset has a fluid issue. In particular, examples involve a platform defining a predictive model for outputting an indicator of whether an asset is likely to have a fluid issue based at least on historical fluid data for one or more assets. The historical fluid data may comprise at least one of a plurality of fluid reports for the one or more assets and an indication of a fluid issue for each fluid report. The platform may receive at least one fluid report associated with a given asset and based at least on the predictive model and the received at least one fluid report, make a determination that the given asset is likely to have a fluid issue. The platform may cause a computing device to output an indication of the determination.

Combined dissolution rate and permeation rate testing apparatus includes temperature-controllable testing cell units arranged on a housing frame. Each testing cell unit includes a donor chamber receivable of dissolution media, a receptor chamber receivable of bodily fluid, gaskets that retain a membrane between the two chambers, and controllable mixers that mix the fluid in the receptor chamber. A flow control arrangement operatively circulates dissolution media through the donor chamber and enables sampling of the dissolution media. Another flow control arrangement operatively circulates bodily fluid through the receptor chamber. An analysis unit analyzes dissolution media removed from the donor chamber and bodily fluid removed from the receptor chamber to provide data about dissolution of a pharmaceutical product dissolved in the dissolution media and permeation of the pharmaceutical product through the membrane into the bodily fluid.

An automatic analyzer having no limitation on a range of a placeable position on a sample placement disk for patient specimens, emergency specimens, quality control samples, and calibration samples, and being capable of performing analysis while changing the number of simultaneously-measurable samples for each type of each specimen is provided. In the automatic analyzer, either a calibration sample dedicated disk or a patient specimen dedicated disk is placed in an analyzing unit 8 as a sample placement disk 19, and the analyzing unit 8 has a disk identifying unit 24 which identifies a type of the sample placement disk 19, and a computer 22 identifies the type of the sample placement disk 19 based on an identification result of the disk identifying unit 24, and performs analysis on a liquid sample based on the identified type of the sample placement disk 19.

An automatic analyzer that sets thresholds of measurement items and remaining reagent amounts. A reagent is dispensed, and checked whether a dead volume is set. If the dead volume is not set, and if the amount of a reagent in a reagent bottle is equal to or larger than a dead volume default value, the process proceeds to the measurement of the next specimen, and the amount is smaller than the default value, the use of the reagent bottle is ended, the reagent bottle is replaced, and the measurement is continued. If the dead volume is set, if the remaining amount of the reagent in the reagent bottle is equal to or larger than the setting amount, the process proceeds to the measurement of the next specimen, and if not, the use of the reagent bottle is ended, the reagent bottle is replaced, and the measurement is continued.

A method is described for supplying consumables to an automated analyzer by providing at least one reagent and at least one solid consumable from a supply module which is docked to the analyzer, followed by undocking the supply module from the analyzer and removing it therefrom. Also described is a respective system and a supply module for supplying consumables to an automated analyzer.

An automatic analyzer is capable of normally maintaining a device condition and exhibiting a stable performance by automatically monitoring a cleaning implementation situation using a wash rack. The automatic analyzer includes an analysis unit, a rack loading unit into which at least a sample rack that holds the sample and a wash rack that holds a cleaning liquid are loaded. A transportation mechanism transports the sample rack and the wash rack to the analysis unit. A management control unit causes the wash rack to be transported to an analysis unit, causes a cleaning operation of the analysis unit by the cleaning liquid held by the wash rack, and causes stopping of the sample analysis operation of the analysis unit to which the wash rack has been transported until a performance of the analysis unit is determined to be normal based on the cleaning operation.

The present invention improves the technology for detecting the level of a reagent in a container using changes of the capacitance, for instance, of an aspiration tube for aspirating the reagent from the container. The present invention can eliminate noises to detection of the capacitance caused by metals surrounding the container and changes of the moving speed of aspiration tube. Changes of the capacitance are detected using an empty container and recorded. The recorded changes are subtracted from changes of the capacitance measured with a container containing a reagent to eliminate the noises to the detection of changes of the capacitance.

An automatic analyzing apparatus capable of eliminating static electricity charged in a specimen container at a specimen dispensing position provided. The automatic analyzing apparatus includes a dispensing mechanism having a probe that aspirates a liquid and an arm that holds the probe, and a static eliminator having a generation source of neutralizing ions and a neutralizing ion blowing mechanism for blowing the neutralizing ions generated in the generation source to a target, which are provided in the dispensing mechanism.

The present disclosure provides an automated system for processing of tissue. The system comprises a plurality of containers for storing at least one of tissue samples, buffer solutions, enzymes and other reagents, tissue processing container for processing of the tissue, and a robotic assembly coupled to the tissue processing container. The robotic assembly is configured to: carry the tissue processing container towards each of the plurality of containers, and align an inlet port of the tissue processing container with an outlet port of each of the plurality of containers for collecting the liquids, and moves the tissue processing container in multiple-planes to perform at least one of the washing processes, digestion process, phase separation process and combination thereof. The system also comprises of a control unit interfaced with the robotic assembly for controlling operations of the robotic assembly while processing the tissue.