Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.

Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.

A method for controlling an electronic pipette, which pipette comprises a piston actuated in a cylinder by a motor, which motor is controlled with a control system, which control system is controlled through a user interface for operating the pipette, wherein actual backlash affecting the movement of the piston of the electronic pipette is measured with a system located in the pipette, the measured backlash value is forwarded to the control system of the electronic pipette, and the movement of the piston is adjusted by the control system based on the measured backlash value.

Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.

Automated isothermal titration micro calorimetry (ITC) system comprising a micro calorimeter with a sample cell and a reference cell, the sample cell is accessible via a sample cell stem and the reference cell is accessible via a reference cell stem. The system further comprises an automatic pipette assembly comprising a syringe with a titration needle arranged to be inserted into the sample cell for supplying titrant, the pipette assembly comprises an activator for driving a plunger in the syringe, a pipette translation unit supporting the pipette assembly and being arranged to place pipette in position for titration, washing and filling operations, a wash station for the titrant needle, and a cell preparation unit arranged to perform operations for replacing the sample liquid in the sample cell when the pipette is placed in another position than the position for titration.

A pipetting device which has a platform with a storage surface, a support device and a main unit arranged on the support device. The storage surface is intended for receiving laboratory containers. The main unit is arranged above the storage surface and has an opening at the bottom with a receiving device for receiving a pipetting head. The pipetting device is wherein the receiving device is movable relative to the storage surface in the three coordinate axis directions (X, Y, and Z).

An automatic analyzer is provided wherein degree of freedom in arrangement of a dispensing mechanism and of a unit provided below the dispensing mechanism is improved. The automatic analyzer comprising a dispensing mechanism driving a probe for a specimen or a reagent, wherein the automatic analyzer comprises an arm of two degrees of freedom supporting the probe, a first shaft and a second shaft that support the arm and transmit power to the arm, and a motor that gives power allowing the first and second shafts to be rotated and vertically moved, the second shaft being divided in an axial direction and having different diameters and, at the time of lowering the arm by the power of the motor, divided one of the second shaft being housed inside the other, whereby the second shaft is shortened.

Methods and systems for automatic spatial and single-cell multi-omics sample preparation and analysis. In examples, a continuous flexible sample strip is dispensed from a strip dispenser assembly, via a rotary mechanism. A prepared biological sample may be mounted to a sample receiving surface of the flexible sample strip to generate a continuous length of prepared sample strip and spatial and single-cell multi-omics data corresponding to the mounted biological sample may be generated based on the continuous length of prepared sample strip. In some embodiments, the methods and systems may be directed to preparing and analyzing a solid phase biological sample, such as an OCT embedded frozen tissue block or a FFPE tissue block. In other embodiments, the methods and systems may be directed to preparing and analyzing a liquid phase biological sample.

Described herein are compositions, uses thereof, and methods for treating a viral infection in a host cell or organism infected by the virus, such as coronaviruses (e.g., severe acute respiratory syndrome coronavirus [SARS-CoV], severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2, the virus and its mutant forms that cause COVID-19], Middle East respiratory syndrome coronavirus [MERS-CoV]), Zika virus, Lassa virus, Crimean Congo hemorrhagic fever virus, hepatitis E virus, and other RNA viruses. Also described herein are synthetic rocaglate compositions, uses thereof, and methods for reducing or inhibiting translation initiation of a messenger ribonucleic acid (mRNA) of a virus in a host cell or organism infected by the virus.

A sample transport system has a carrier configured to hold a sample tube for a sample to be transported and mixed, a transporter configured to support the carrier, a guide portion configured to impart motion to the carrier on the transporter and deliver the carrier to a destination location, and a controller. The controller is configured to identify instructions associated with the sample, the instructions including a movement profile configured to cause mixing of the sample, communicate with the guide portion to cause the carrier to follow the movement profile on the transporter to cause the mixing of the sample, and deliver the sample to the destination location.