A method for processing a sample of a cell culture composition includes diluting the sample followed by filtering the diluted sample, wherein the dilution may be at least 10 parts by volume of a diluent to one part sample, and the filter may be a porous membrane with a molecular weight cutoff of less than 20,000 Daltons. The dilution may be carried out at a multiple-port dilution valve having a first condition and a second condition. The sample may be mixed with the diluent at a predetermined dilution ratio when the dilution valve is in the second condition.

The present invention relates to a preparative chromatography system (200, 500, 800) and a chromatography process (400, 700) adapted to repetitive cycling of chromatography volumes. The system (200, 500, 800) comprises at least two upstream pumps (203a, 803a, 203b, 803b) and separate flow paths (220) from process liquid sources to the chromatography device (200, 500, 800). The system (200, 500, 800) is arranged to prime one flow path (220) with one process liquid while providing another process liquid to the chromatography device and thereby minimizing the hold-up volume of the system (200, 500, 800).

Methods, systems and apparatuses using: (i) a flow control unit including: piping inlets and outlets for connecting thereby to different parts located at different locations of a water facility (WF) and of the apparatuses themselves and multiple controllable valves, each being deployed at a different inlet or outlet of the multiple piping inlets and outlets; (ii) a detection unit including at least one sensor for sensing characteristics of the WF in various locations and/or states of the WF; and a controller, configured to control operation of the valves, for measuring one or more characteristics of a selected detection location or state of the WF or of water manipulated within the apparatuses. The methods, systems and apparatuses may further be configured to apply manipulations over a water sample, sampled from the WF and/or over water from the WF and measure responses to the applied manipulation(s).

An automated method for performing a leakage test of a fluidic system of an in-vitro diagnostic device as well as an automated in-vitro diagnostic device comprising a controller configured to perform the leakage test. The method comprises activating a pump to provide a fluid from a fluid supply into an electrically conductive probe. The probe is positioned so that a tip of the probe is at a predetermined distance from a reference surface of a reference element. In case of leakage, an electrical signal or change in an electrical signal or a change of the electric or magnetic field between the probe and the reference element is detected in a predetermined measuring time period and at least one maintenance action is triggered.

A liquid chromatography monitoring system comprises a computer or electronic controller comprising computer-readable instructions operable to: (a) draw a fluid into a syringe pump; (b) configure a valve so as to fluidically couple the pump to either a fluidic pathway through a fluidic system or to a plug that prevents fluid flow; (c) cause the syringe pump to progressively compress the fluid therein or expel the fluid to the fluidic pathway, while measuring a pressure of the fluid; (d) determine a profile of the variation of the measured pressure; (e) compare the determined profile to an expected profile that depends upon the fluid; and (f) provide a notification of a sub-optimal operating condition or malfunction if the determined profile varies from the expected profile by greater than a predetermined tolerance.

In a gas analysis apparatus including analyzers that need ignition, such as FIDs, in order to make it possible to surely ignite the analyzers while downsizing the entire apparatus, the apparatus includes first and second analyzers to accept a sample gas, a first gas line provided with the first analyzer, a second gas line provided with the second analyzer and joined downstream of the first analyzer in the first gas line. At least one of the first analyzer and the second analyzer is configured to cause pressure fluctuations in the gas line including the analyzer when analyzing the sample gas. A first backflow prevention mechanism is disposed between another of the analyzers and a junction of the gas lines. The first backflow prevention mechanism is configured to prevent a fluid from flowing backward from the one of the analyzers through the junction toward the another of the analyzers.

The present invention relates to a chromatography system and a method therefor. The chromatography system comprising an inlet port (102) for receiving a sample, an outlet port (106) for delivering the sample, a detector (201), a column (104), and a valve (202) in fluid communication with the inlet port, the outlet port, the detector, and the column. The valve (202) comprises a first position (304) wherein the inlet port is in fluid communication with the outlet port via a first fluid path comprising the detector and the column, wherein the detector is arranged upstream the column. The valve comprises a second position (404) wherein the inlet port is in fluid communication with the outlet port via a second fluid path comprising the detector and the column, wherein the detector is arranged downstream the column.

Systems and methods are described to concentrate and homogenize a remote sample for analysis. A sample concentration and homogenization system embodiment includes, but is not limited to, at least a first valve, at least a first column fluidically coupled to the first valve, a flow meter fluidically coupled with the first column when the first valve is in a first flow path configuration to measure an amount of the liquid sample passed through the first column, and a homogenization valve including a sample homogenizing loop in which the concentrated sample is homogenized.

A liquid analyzer comprises a liquid sample intake for immersion in a liquid sample; at least one measurement zone; and a first pump module operable to effect liquid flow from sample intake towards the at least one measurement zone. A first pressure monitor is provided to measure pressure between the sample intake and the at least one measurement zone and the operation of the first pump module to regulate the liquid flow in the liquid conduits is regulated in dependence thereon.

The disclosure concerns a method for operating an automated analyzer, including transporting a liquid containing a plurality of particles into a chamber, such as a reactor chamber and/or measuring cell chamber of the analyzer, introducing a gas or gas mixture, for example, air into the chamber, such as through the liquid present in the chamber so that the particles in the liquid are stirred up, and subsequently draining at least part of the liquid from the chamber through a fluid line ending in the chamber and an open valve arranged in the fluid line.