Disclosed are a system and method for evaluating a tissue sample that has been removed from a subject. Movement of fluid through the tissue sample is monitored by measuring time of flight of acoustic waves passed through the tissue sample. A system for performing the method can include a transmitter that outputs the energy and a receiver configured to detect the transmitted energy. Using the disclosed method and system, an optimized protocol for ensuring adequate distribution of the fluid throughout a variety of tissue types and/or sample sizes can be developed and utilized.

A mounting structure includes a first substrate that has a first surface on which a functional element is provided, a wiring that is provided at a position which is different from a position of the functional element on the first surface, and is connected to the functional element, a second substrate that has a second surface facing the first surface, and a conductor that is provided on the second surface, and is connected to the wiring and the functional element, in which the shortest distance between the functional element and the second substrate is longer than a distance between a position where the wiring is connected to the conductor, and the second substrate.

Methods for processing data acquired using ultrasound elastography, in which shear waves are generated in a subject using continuous vibration of the ultrasound transducer, are described. The described methods can effectively separate shear wave signals from signals corresponding to residual motion artifacts associated with vibration of the ultrasound transducer. The systems and methods described here also provide for real-time visualization of shear waves propagating in the subject.

This disclosure describes systems and methods for ultrasound imaging and targeting. In one example, the systems and methods improve targeting and imaging through a heterogenous medium by using the angular spectrum approach (ASA) alone or in combination with passive acoustic mapping (PAM). In another example, the systems and methods improve the ultrasound imaging of vessels using microbubbles. The imaging of the vessels is also aided by the ASA and PAM. A closed loop controller is described that adjusts the ultrasound pressure provided to a region of interest to a desired pressure based at least in part on the harmonic, ultra-harmonic, sub-harmonic, or broadband frequency ranges for the microbubbles.

Methods for measuring mechanical properties of an object or subject under examination with an ultrasound system and using unfocused ultrasound energy are provided. Shear waves that propagate in the object or subject are produced by applying unfocused ultrasound energy to the object or subject, and measurement data is acquired by applying focused or unfocused ultrasound energy to at least one location in the object or subject at which shear waves are present Mechanical properties are then calculated from the acquired measurement data.

In a first aspect, the present description relates to a system for non-invasively characterizing a heterogeneous medium using ultrasound, comprising at least one first array (10) of transducers configured to generate a series of incident ultrasound waves in a region of said heterogeneous medium and record the ultrasound waves which are backscattered by said region as a function of time, as well as a computing unit (42) which is coupled to said at least one first array of transducers and configured to: record an experimental reflection matrix defined between an emission basis at the input and the basis of the transducers at the output; determine, from said experimental reflection matrix, at least one first wideband reflection matrix defined in a focused base at the input and output; determine a first distortion matrix defined between said focused basis and an observation basis, said first distortion matrix resulting, directly or after a change of basis, from the term-by-term matrix product of said first wideband reflection matrix defined between said focused basis and an aberration correction basis, with the phase-conjugated matrix of a reference reflection matrix defined for a model medium, between the same bases; determine, from said first distortion matrix, at least one mapping of a physical parameter of said heterogeneous medium.

To obtain an absorption distribution from a detected signal with a practical device. Light is applied to a subject, and a photoacoustic signal generated in the subjectA photoacoustic is detected. From the detected photoacoustic signal, a light differential waveform, which is a differential waveform of a temporal waveform of the light applied to the subject, is deconvolved. As a result of this deconvolution, an absorption distribution is obtained.

An ultrasound device, including a profile generator, an encoder configured to receive a profile signal from the profile generator, and an attenuator configured to receive a signal representing an output of an ultrasound sensor and coupled to the encoder to receive a control signal from the encoder, the attenuator including a plurality of attenuator stages, the attenuator configured to produce an output signal that is an attenuated version of the input signal.

Systems and methods for performing shear wave elastography using push and/or detection ultrasound beams that are generated by subsets of the available number of transducer elements in an ultrasound transducer. These techniques provide several advantages over currently available approaches to shear wave elastography, including the ability to use a standard, low frame rate ultrasound imaging system and the ability to measure shear wave speed throughout the entire field-of-view rather than only those regions where the push beams are not generated.

A method for visualizing details in a sample including directing an excitation beam to an excitation location below a surface of the sample, to generate signals in the sample; directing an interrogation beam toward the excitation location of the sample; directing a signal enhancement beam to the sample, to raise a temperature of a portion of the sample by 5 Kelvin or less, compared to a temperature of the portion of the sample in absence of the signal enhancement beam; detecting a portion of the interrogation beam returning from the sample that is indicative of the generated signals.