The invention relates to a wave-emitting device comprising an electromechanical actuator stimulated by a signal generator that allows it to generate torsional waves with a higher amplitude, and to an ultrasonic transducer comprising said device. The use of said devices allows the reconstruction of the structural characteristics of the materials subject to the waves generated by the emitter device.

A system for screening tissue on the presence of malignant cells in said tissue, which system comprises a wave detector and a data processing device connected or connectable to the wave detector for processing data received from the wave detector, which system comprises an actuator to excite the tissue which is suspected to comprise malignant cells, and the data processing device comprises an analyzer connected to the wave detector for analyzing the data received from the wave detector in response to the actuator exciting the tissue, which analyzer is arranged to identify the tissue with an elevated probability to comprise malignant cells in comparison with tissue that is not suspected to comprise malignant cells in an individual case. The inventors remark that the identification of high but symmetrical outcome results can be used in a population-based stratification of risk of developing malignant cells and can serve as a biomarker in risk-based screening approaches.

Method and system for ultrasonic characterization of a medium Method for ultrasonic characterization of a medium, comprising generating a series of incident ultrasonic waves, generating an experimental reflection matrix Rui(t) defined between the emission basis (i) as input and a reception basis (u) as output, determining a focused reflection matrix RFoc(rin, r.sub.out, at) of the medium between an input virtual transducer (Win) calculated based on a focusing as input to the experimental reflection matrix and an output virtual transducer (TVout) calculated based on a focusing as output from the experimental reflection matrix, the responses of the output virtual transducer (TVout) being obtained at a time instant that is shifted by an additional delay 6t relative to a time instant of the responses of the input virtual transducer (TVin).

Methods, systems and computer program products for determining a property for a sample having a target region using ultrasound data from an ultrasound scanner include generating at least one spatial coherence curve based on ultrasound backscatter data in the target region, the spatial coherence curve comprising coherence values as a function of depth in the sample; and determining a property for a sample in response to the spatial coherence curve as a function of depth.

The subject disclosure presents systems and computer-implemented methods for evaluating a tissue sample that has been removed from a subject. A change in speed of the energy traveling through the sample is evaluated to monitor changes in the biological sample during processing. The rate of change in the speed of the energy is correlated with the extent of diffusion. A system for performing the method can include a transmitter that outputs the energy and a receiver configured to detect the transmitted energy. A time-of-flight of acoustic waves and rate of change thereof is monitored to determine an optimal time for soaking the tissue sample in a fixative.

A method is disclosed that permits calculation of reagent concentrations (in SI units) over time and space within a tissue sample as the sample is immersed in the reagent and the reagent diffuses into the tissue sample. The disclosed method has yielded the surprising result that once a formaldehyde concentration at all points within a tissue sample exceeds about 90 mM during a cold step of a cold+hot fixation protocol, the hot step of the fixation protocol can be commenced to provide reliable detection of molecular targets and preservation of tissue morphology in downstream analyses.

The present invention relates to an apparatus for treating a pathology, comprising: an ultrasonic generation device (1), a remote control unit (2) to supply electricity to the device (1), electrical connection means (31, 32) between the device (1) and the control unit (2), remarkable in that the control unit (2) is programmed to assess the quality of the acoustic coupling between the ultrasonic device (1) and a tissue to be treated.

A thermoacoustic measurement probe may include an open-ended hollow radio-frequency (RF) waveguide; and a thermoacoustic transducer, wherein the open-ended hollow RF waveguide, in the form of a sleeve, surrounds and is mechanically joined to the thermoacoustic transducer.

Disclosed are a photo-acoustic sensor device and a photo-acoustic sensing method of the same. The sensing method includes providing a source light in a subject and receiving an ultrasonic wave generated in the subject by the source light. The source light may have a wavelength of 1400 nm to 2500 nm in a near-infrared band.

The systems and methods provided herein relate to the performance of inverse reconstruction algorithms from ultrasound radiofrequency data and stress-strain data. These systems and methods can be applied to any soft tissue mechanical measurements, providing information about both mechanical properties and fiber orientation, and the relationships between them.