Provided is a test system including at least the following: permeabilising means and/or lysis of at least one pathogen and/or at least one cell, means for capturing and/or making parts of the pathogens and/or cells, means for localising, immobilising and/or enriching at least one component of a pathogen and/or a cell, means for image processing preferably including an optical magnifying unit, enabling an optical reading out of at least one means for localising, immobilising and/or enriching can be carried out.

Methods of treating and preventing malaria infection, comprising administering a therapeutically effective amount of cell permeability modulating therapy are provided herein. Among other things, the present disclosure provides parameters that define subjects who are relatively susceptible or resistant to malaria infection. The present disclosure also provides therapeutic strategies for increasing malarial resistance and/or imparting a resistant state on subjects.

Embodiments are directed to diagnostic devices based on surface-enhanced Raman scattering comprising: an inlet module receiving liquid to be analyzed; a reaction module having a first region arranged with a receiving hole and a second region arranged with an output hole, wherein the receiving hole is communicated with the output hole through a flow channel configured with at least one chemical set, the reaction module receives the liquid delivered by the inlet module via the receiving hole, and the liquid to be analyzed flows through the chemical sets placed in the flow channel to obtain nanoparticles-carrying liquid, and the nanoparticles-carrying liquid configured to flow into the second region of the reaction module; and a detection module receiving the nanoparticle-carrying liquid from the output hole of the reaction module.

The present invention relates to novel genetic markers associated with endometriosis and risk of developing endometriosis, and methods and materials for determining whether a human subject has endometriosis or is at risk of developing endometriosis and the use of such risk information in selectively administering a treatment that at least partially prevents or compensates for an endometriosis related symptom.

A system, method, apparatus and diagnostic test for Plasmodium vivax, to determine a likelihood of a specific timing of infection by P. vivax in a subject, and hence identify individuals with a high probability of being infected with otherwise undetectable liver-stage hypnozoites. The system, method, apparatus and diagnostic test relate to the identification of hypnozoites (“dormant” liver-stages), or at least of the likelihood of the subject being so infected. Optionally and preferably, the specific timing relates to recent infections, for example within the last 9 months.

Disclosed is a blood analyzer including: a first sample preparation unit configured to prepare, from a blood sample, a first measurement sample for measuring a red blood cell infected with malaria; a second sample preparation unit configured to prepare, from the blood sample, a second measurement sample for measuring intrinsic fluorescence of a red blood cell; a light source unit configured to apply light to the first and the second measurement samples; a detection unit configured to detect fluorescence and scattered light generated from the first measurement sample to which light has been applied, and detect intrinsic fluorescence generated from the second measurement sample to which light has been applied; and an information processing unit configured to generate information about malaria infection based on fluorescence and scattered light detected from the first measurement sample, and generate information about iron-deficiency anemia based on intrinsic fluorescence detected from the second measurement sample.

A diagnostic system that includes a cartridge and a reader. The cartridge can contain a patient sample, such as a blood sample. The cartridge is inserted into the reader and the patient sample is analyzed. The sample can be processed for data collection and analysis to provide interpretative results indicative of a disorder, condition, disease or infection of the patient. For example, the data collection and analysis can determine one or more hemozoin characteristics.

The present invention relates to functional binding fragments comprising the minimal CSA-binding fragments of VAR2CSA and their use in identification and isolation of circulating trophoblast and/or fetal cells suitable for non-invasive prenatal diagnostic testing. Thus, the present invention describes methods of identifying and isolating trophoblast and/or fetal cells in a biological sample such as a maternal blood, and utilizing this for prenatal diagnostics.

Antibodies that bind to the circumsporozoite protein (CSP) of Plasmodium falciparum. Use of such antibodies as anti-malarial agents, to confer protection against infection by malarial parasites such as P. falciparum by insect vector transmission. Diagnosis of malaria using anti-CSP antibodies. Methods of determining efficacy of candidate vaccine compositions in development and testing of anti-malarial vaccines.

K13-propeller polymorphism is a useful molecular marker for tracking the emergence and spread of ART-resistant P. falciparum. The invention encompasses methods, compositions, and kits for detecting and genotyping Plasmodium, for example, Plasmodium falciparum. The methods, compositions, and kits can be used to detect the presence or absence of a mutated K-13 propeller nucleic acid or protein in the sample.