A dynamic imaging system for use with endoscope, or as an element of a video endoscope, utilizes path length differences and/or a variable aperture size to expand a usable depth of field and/or improve image resolution in an area of interest in the image field. In some implementations, the imaging system utilizes a variable aperture in conjunction with unequally spaced image sensors placed downstream from a beam splitter. An imaging system captures multiple focal planes of an image scene on separate sensors. A variable aperture permits the capture of enhanced resolution images or images with longer depths of field. These differently focused images and/or images with different resolutions and depths of field are then combined using image fusion techniques.

A variable magnification optical system capable of realizing a high-resolution observation image display system that can arbitrarily change an observation field of view without changing a working distance of an observation optical system while keeping the observation optical system small in size and an imaging apparatus including the variable magnification optical system.

An apparatus for imaging an anatomical structure(s) can be provided. For example, a housing arrangement can have a shape of a pill and can be to be delivered to the anatomical structure(s). An imaging arrangement can be configured to generate a microscopic image of the anatomical structure(s), wherein the imaging arrangement can include a variable focus lens, and can be provided in the housing arrangement.

A stereoscopic-vision endoscope includes an objective optical system, a relay optical system, a first lens unit, a light-beam splitting element, a second lens unit, and an image sensor. An intermediate image, a first image, and a second image are formed in a common optical path, a first optical path, and a second optical path respectively. The light-beam splitting element has a surface of incidence and a surface of emergence. A first light ray which passes through the intermediate image and reaches first image and a second light ray which passes through the intermediate image and reaches the second image are refracted to be away from an optical axis of the common optical path on the surface of incidence, as well as are refracted to be closer to the optical axis of the common optical path on the surface of emergence.

A dynamic imaging system of an endoscope that adjusts path length differences or focal points to expand a usable depth of field. The imaging system utilizes a variable lens to adjust the focal plane of the beam or an actuated sensor to adjust the detected focal plane. The imaging system is thus capable of capturing and adjusting the focal plane of separate images captured on separate sensors. The separate light beams may be differently polarized by a variable wave plate or a polarized beam splitter to allow separate manipulation of the beams for addition of more frames. These differently focused frames are then combined using image fusion techniques.

In various embodiments, a scope-based imaging system is introduced. An optical sensor assembly located at the tip of the scope may include the CMOS sensors, filters, and lenses/mirrors, to perform fluorescence imaging using the scope.

A system, device, and accompanying software for the remote, three-dimensional, and high-throughput imaging and analysis of human lesions, across a range of wavelengths, lens radii and imaging sensors. This system, device, and software generates and analyses of tumor images at infrared wavelengths through the use of miniaturized, liquid lenses. It has a number of clinical, diagnostic, research, and other imaging applications, including the remote, three-dimensional, and high-throughput imaging and analysis of human cancer tumors.

A tunable prism for vision correction of a patient and other applications is disclosed herein. The tunable prism includes a first transparent plate; a second transparent plate; and a transparent balloon, a transparent ball, a transparent gel, or a transparent bag filled with a transparent gel disposed between the first and second transparent plates. A tilt of at least one of the first and second transparent plates is configured to be modified so as to adjust a prism diopter of the tunable prism.

Improved fluoresced imaging (FI) and other sensor data imaging processes, devices, and systems are provided to enhance use of endoscopes with FI and visible light capabilities. A first optical device is provided for endoscopy imaging in a white light and a fluoresced light mode with an image sensor assembly including one or more image sensors. A mechanism in the first optical device to automatically adjust the focus of the first optical device wherein the automatic focus adjustment compensates for a chromatic focal difference between the white light image and the fluoresced light image caused by the dispersive or diffractive properties of the optical materials or optical design employed in the construction of the first or second optical devices, or both. Adjustment mechanisms are provided using liquid lenses or repositioning sensors. The design may be integrated with a scope or detachable.

In various embodiments, a scope-based imaging system is introduced. An optical sensor assembly located at the tip of the scope may include the CMOS sensors, filters, and lenses/mirrors, to perform fluorescence imaging using the scope.