This disclosure relates to a screening test method, device, and kit for carbohydrates found in a biological sample and associated conditions including, cancerous and precancerous conditions. Specifically, the method tests abnormal carbohydrates in a biological sample using reagents of galactose oxidase, and Schiff's Reagent. The screening test method, device, and kit provides expanded testing capabilities across a range of known conditions and in an otherwise healthy population. This disclosure further relates to the use of the device or kit for an initial evaluation for cancerous and precancerous conditions in people without obvious signs and symptoms, and cancer recurrence in at point-of-care facility or at home.

A chromogenic absorbent material for an animal litter includes an oxidizing agent responsive to peroxidatic/pseudoperoxidatic activity in an animal excretion or a first catalytic compound generating the oxidizing agent in situ. The material also includes a chromogenic indicator being chromogenically responsive to the oxidizing activity of the oxidizing agent, and an absorptive material which is porous, for absorbing the animal excretion. The absorptive material includes a water-absorbing polysaccharide providing absorptive properties to the chromogenic absorbent material; and may also include a second polysaccharide and a superabsorbent polymer. The material may be obtained in the form of particles having a low density and a high porosity, and is usable in conjunction with an animal litter for detecting various diseases in animals.

The disclosure relates to the treatment, diagnosis and/or prevention of multiple sclerosis (MS) by using an immunodominant protein or peptide. More particular the invention relates to the field of antigen specific immunotherapies, such as the induction of tolerance.

Compositions and methods for detecting β-hydroxybutyrate in a biological fluid from a subject in need thereof are disclosed. Also disclosed are compositions and methods of reducing an optical change in a composition for detecting the β-hydroxybutyrate during storage before the composition is exposed to the β-hydroxybutyrate.

Oxygen sensing luminescent dyes, polymers and sensors comprising these sensors and methods of using these sensors and systems are provided.

The present invention provides a method for measuring the concentration of an analyte in a test solution wherein the analyte is mevalonic acid and/or 3-hydroxymethylglutaryl coenzyme A, comprising the following steps (p) and (q): (p) a step of allowing an enzyme that catalyzes a reaction represented by Reaction Formula 1 and an enzyme that catalyzes a reaction represented by Reaction Formula 2 to act on a test solution containing mevalonic acid and/or 3-hydroxymethylglutaryl coenzyme A in the presence of a hydrogen acceptor X, a hydrogen donor Y, and coenzyme A; and (q) a step of measuring an amount of: a reduced hydrogen acceptor X that is produced; or an oxidized hydrogen donor Y that is produced; or a hydrogen acceptor X that is decreased; or a hydrogen donor Y that is decreased, wherein the hydrogen donor Y and the reduced hydrogen acceptor X are not the same.

The invention relates to a device and method for detecting a specific analyte in a liquid sample. The device that can be used in the method contains at least one fluid line, at least one receiving region for receiving a liquid sample, at least one enzymes region containing at least one determined enzyme and/or at least one acidification region containing at least one acid. The device also contains at least one reaction region used to form gas bubbles. The fluid line transports the liquid sample from the receiving region via the enzyme region and/or the acidification region to the reaction region by means of capillary forces and/or at least one micropump allowing fast, simple and cost-effective detection of a specific analyte in a liquid sample, the detection being carried out with a high level of sensitivity, specificity and precision. The invention further relates to uses of the device.

Some embodiments described herein relate to a sensor that includes a first a first polymer-luminescent sensing compound configured to produce a first luminescent signal in the presence of a first analyte and a second polymer-luminescent sensing compound configured to produce a second luminescent signal in the presence of a second analyte. The second luminescent signal can have a luminescent lifetime that is at least 1.1 times greater than a luminescent lifetime of the first luminescent signal. Such temporally differences in signal can be used to deconvolute the first luminescent signal from the second luminescent signal even when, for example, the first luminescent signal and the second luminescent signal have the same or a similar emission spectrum.

Methods and analyte sensors including at least a first working electrode having a first active area thereon, and performing a dip coating operation to deposit a bilayer membrane upon the first working electrode and the first active area. The bilayer may include an inner layer having a first membrane polymer and an outer layer having a second membrane polymer, the first membrane polymer and the second membrane polymer differing from one another. The dip coating operation may comprise one or more first dips in a first membrane formulation to form the inner layer of the bilayer membrane and one or more second dips in a second membrane formulation to form the outer layer of the bilayer membrane upon the inner layer.

Disclosed are compositions and methods for detecting the presence or level of gamma-hydroxybutyric acid (GHB), or for diagnosing GHB toxicity or overdose.