Systems and methods for imaging tissue are described. Particularly, systems and methods of imaging an inner limiting membrane, epi-retinal membrane, or posterior vitreous cortex of a patient's eye are disclosed. Imaging an inner limiting membrane, epi-retinal membrane, or posterior vitreous cortex may include applying a stain to the inner limiting membrane, epi-retinal membrane, or posterior vitreous cortex of the patient's eye, causing the stain to produce fluorescent light having a wavelength within a near-infrared range, capturing the fluorescent light, and producing an Optical Coherence Tomography (OCT) image of the inner limiting membrane, epi-retinal membrane, or posterior vitreous cortex with an OCT imaging system that is configured to detect light within the near-infrared range.

A fundus photography device includes: an OCT optical system configured to detect interference between a measurement light from a fundus of a subject's eye and a reference light from a reference optical path; a fundus photography optical system configured to detect a reflected light from the fundus; a controller configured to generate a tomographic image of the fundus and a first front image of the fundus based on an output signal from the OCT optical system, and generate a second front image of the fundus based on an output signal from the fundus photography optical system. The controller is configured to cause simultaneous display of the first front image and the second front image in different display regions on a monitor.

An optical coherence tomography device includes an OCT optical system that irradiates a tissue of the subject's eye with measurement light from a light source, and detects interference between reference light and the measurement light reflected from the tissue by using a detector, and a processor, in which the processor performs a generation process of acquiring A-scan data based on a signal output from the detector in a cycle of 300 kilohertz or more and generating three-dimensional OCT data at any time based on the acquired A-scan data, and performs an analysis process on each piece of the three-dimensional OCT data generated at any time through the generation process, so as to output a real-time analysis result of the three-dimensional OCT data which is generated at any time.

Provided is an image processing apparatus, including: an information acquiring unit configured to acquire three-dimensional polarization tomographic information and three-dimensional motion contrast information of an object to be inspected using tomographic signals of light beams having polarizations different from each other, which are obtained by splitting combined light obtained by combining return light from the object to be inspected irradiated with measuring light and reference light corresponding to the measuring light; an extracting unit configured to extract a specific region of the object to be inspected using the three-dimensional polarization tomographic information; and an image generating unit configured to generate a motion contrast enface image of the extracted specific region using the three-dimensional motion contrast information.

An apparatus for use in the measurement of the optical density of macular pigment in the human eye, and an apparatus for the use in measuring the lens optical density of a human eye. The apparatus is particularly applicable to flicker photometers, which are used to measure the macular pigment in the human eye.

There is provided a method of processing image data defining a fundus image of a retina to include supplementary information on a designated feature in the fundus image, comprising: designating (S10) a feature in the fundus image; receiving (S20) OCT data of a C-scan of the retina; selecting (S30) a subset of the OCT data representing a volumetric image of a part of the retina at a location on the retina corresponding to a location of the designated feature in the fundus image; processing (S40) the selected subset to generate, as the supplementary information, supplementary image data indicative of a variation, along a depth direction of the retina, of a measured reflectance of the eye in the selected subset; and combining (S50) the image data with the supplementary image data, such that an image defined by the combined data provides an indication of the variation at the designated feature.

The disclosure herein provides methods, systems, and devices for improving optical coherence tomography machine outputs through multiple enface optical coherence tomography angiography averaging techniques. The embodiments disclosed herein can be utilized in ophthalmology for employing optical coherence tomography (OCT) for in vivo visualization of blood vessels and the flow of blood in an eye of a patient, which is also known generally as optical coherence tomography angiography (OCTA). The embodiments disclosed herein can use linear registration, affine registration and/or elastic registration to align a plurality of optical coherence tomography angiography images or videos at corresponding superficial vascular layers having well-defined features or landmarks, and to apply the same linear registration, affine registration and/or elastic registration settings and/or data to corresponding deeper tissue layers, such as the choriocapillaris, which generally do not have well-defined features or landmarks, in order to align a plurality of corresponding deeper tissue layers for the purpose of averaging the images or video to produce a clearer and more accurate image or video of the tissue structure at deeper tissue layers.

An image processing apparatus includes a planar image acquisition unit configured to acquire a planar image of a subject, a tomographic image acquisition unit configured to acquire a tomographic image indicating a polarization state of the subject, and a display control unit configured to cause a display unit to display the planar image and the tomographic image indicating the polarization state side by side.

An ophthalmologic apparatus measures a dimension of an eye to be examined. The ophthalmologic apparatus includes a light source, an incidence member, an acquisition unit, and a display unit. The incidence member causes light from the light source to be incident on a plurality of different positions in the eye to be examined. The acquisition unit acquires a two-dimensional tomographic image of an interior of the eye to be examined on the basis of a plurality of interference signals acquired as a result of the incidence member causing the incidence of light on the plurality of different positions. The display unit displays the acquired two-dimensional tomographic image.

A method for evaluating retinal function and testing the visual field of a patient by monitoring how the patient tracks a target image on a display that comprises displaying the target image on the display such that it is located at a first position on the display and visible to the patient. The process continues by identifying what portion of the display the patient is looking at, selecting a location of the patient's retina to test, and calculating, based at least in part on what portion of the display the patient is looking at, a second position on the display corresponding to the selected location of the patient's retina. The target image is displayed at the second position on the display and the process identifies how many eye movements the patient made to look at the target at the second position. Based at least in part on the number of eye movements, the process determines whether the patient was able to see the target at the second position.