Methods, apparatus, and systems for performing an ophthalmic diagnostic test are disclosed. In one aspect, a head-wearable device for administering an ophthalmic test to a subject can comprise a head-wearable frame for mounting the device onto the subject's head, and a light seal configured for coupling to the frame so as to isolate at least one eye of the subject from ambient light when the device is worn by the subject.

Configurations are disclosed for a health system to be used in various healthcare applications, e.g., for patient diagnostics, monitoring, and/or therapy. The health system may comprise a light generation module to transmit light or an image to a user, one or more sensors to detect a physiological parameter of the user's body, including their eyes, and processing circuitry to analyze an input received in response to the presented images to determine one or more health conditions or defects.

Configurations are disclosed for a health system to be used in various healthcare applications, e.g., for patient diagnostics, monitoring, and/or therapy. The health system may comprise a light generation module to transmit light or an image to a user, one or more sensors to detect a physiological parameter of the user's body, including their eyes, and processing circuitry to analyze an input received in response to the presented images to determine one or more health conditions or defects.

A waveguide apparatus includes a planar waveguide and at least one optical diffraction element (DOE) that provides a plurality of optical paths between an exterior and interior of the planar waveguide. A phase profile of the DOE may combine a linear diffraction grating with a circular lens, to shape a wave front and produce beams with desired focus. Waveguide apparati may be assembled to create multiple focal planes. The DOE may have a low diffraction efficiency, and planar waveguides may be transparent when viewed normally, allowing passage of light from an ambient environment (e.g., real world) useful in AR systems. Light may be returned for temporally sequentially passes through the planar waveguide. The DOE(s) may be fixed or may have dynamically adjustable characteristics. An optical coupler system may couple images to the waveguide apparatus from a projector, for instance a biaxially scanning cantilevered optical fiber tip.

A waveguide apparatus includes a planar waveguide and at least one optical diffraction element (DOE) that provides a plurality of optical paths between an exterior and interior of the planar waveguide. A phase profile of the DOE may combine a linear diffraction grating with a circular lens, to shape a wave front and produce beams with desired focus. Waveguide apparati may be assembled to create multiple focal planes. The DOE may have a low diffraction efficiency, and planar waveguides may be transparent when viewed normally, allowing passage of light from an ambient environment (e.g., real world) useful in AR systems. Light may be returned for temporally sequentially passes through the planar waveguide. The DOE(s) may be fixed or may have dynamically adjustable characteristics. An optical coupler system may couple images to the waveguide apparatus from a projector, for instance a biaxially scanning cantilevered optical fiber tip.

A contact lens according to an embodiment of the present disclosure includes: a lens unit to be placed on an eyeball; and an optical device that is mainly provided in a circular region opposed to a pupil that becomes small by contraction in a case where the lens unit is placed on the eyeball, and provides an action that is different from an action of the lens unit to light entering the eyeball.

This invention relates to testing and determining a threshold value used in psychometric testing in field of ophthalmology, neuro-ophthalmology and visual neuropsychology. The method comprises at least the following steps: a) displaying a symbol with a distinctive visual appearance and with a stimulus level to a display at a stimulus time-point, the symbol selected from a group of possible symbols, b) monitoring if a response is given on a response device with multiple choices, each choice representing a possible visual appearance or location of the symbol, and b1) if a response is not given in a response time-limit from the stimulus time-point, increasing the stimulus level of the symbol by a predetermined step and returning to step a), or b2) if a response is given in the response time-limit from the stimulus time-point, comparing the response to symbol displayed in step a), and c1) if the response does not correspond to the symbol displayed in step a), producing, e.g. displaying, an error feedback and returning to step a), or c2) if the response corresponds to the symbol displayed in step a), determining if stop criteria for the test is satisfied, and d1) if stop criteria for the test is not satisfied, decreasing the stimulus level by a predetermined step and returning to step a), or d2) if stop criteria for the test is satisfied, ending the test.

Methods of using visual functions such as dark adaptation, low luminance visual acuity, low luminance deficit, contrast sensitivity and scotopic sensitivity as functional biomarkers for statin therapy in AMD. These biomarkers can be used, for example, to support clinical trials of statin therapy for AMD by identifying participants more likely to respond, by providing an early indication of response, or by serving as an endpoint; or to support treatment of AMD patients with statins by identifying patients more likely to respond, by providing an early indication of responders vs. non-responders, or by confirming a treatment benefit.

Embodiments of the present invention provide a computer-implemented method of determining a parameter indicative of dark adaptation of an eye, comprising receiving threshold data from a dark adaptometer indicative of a perception threshold of the eye, fitting first and second models to the threshold data, wherein the first model is associated with a first dark adaptation mechanism and the second model is associated with the first dark adaption mechanism and a second dark adaptation mechanism, determining a confidence associated with the fitting of each of the first and second models to the received threshold data, iteratively repeating the steps of receiving the threshold data and fitting the first and second models in dependence on the determined confidence, and outputting an indication of one or more parameters indicative of dark adaptation of an eye associated with one or both of the first and second models.

Mobile computer devices and systems for refraction determination of an eye, for example for objective refraction determination and/or subjective refraction determination, are provided. Here, a display of the mobile computer device can be driven to display an image for refraction determination.