A method and system for providing motion analysis data useful in identifying, monitoring, or treating neurological conditions. The preferred embodiment uses an optical coherence tomography system to obtain information about capability of motion control and control of involuntary eye movement. Alternate embodiments are taught.

A device receives a two-dimensional (2-D) image that depicts a cross-sectional view of a macula comprised of layers and boundaries to segment the layers, and determines spatial coordinates of the 2-D image that include x-coordinates and y-coordinates. The device uses a data model, that has been trained using a deep learning technique, to process the 2-D image and the spatial coordinates to generate boundary maps that indicate likelihoods of voxels of the 2-D image being in positions that are part of particular boundaries. The device determines, by analyzing the boundary maps, an initial set of boundary positions, and determines a final set of boundary positions by using a topological order identification technique to refine the initial set of boundary positions. The device determines the thickness levels of the layers of the macula based on the final set of boundary positions, and performs one or more actions based on the thickness levels.

Disclosed herein is a method of segmenting a volumetric image comprising a plurality of slices, the method comprising: inputting a target slice of the volumetric image to a deep neural network (DNN) having a multi-task learning architecture, the multi-task learning architecture comprising: a segmentation DNN that is configured to output a segmentation of the target slice; and a reconstruction DNN that is configured to: receive a plurality of adjacent slices to the target slice; and output a reconstruction of the target slice based on the plurality of adjacent slices; wherein the reconstruction DNN is further configured to share spatial information with the segmentation DNN, the spatial information being indicative of correlations between the adjacent slices and the target slice.

An optical measurement system and apparatus for carrying out cataract diagnostics in an eye of a patient includes a Corneal Topography Subsystem, a wavefront aberrometer subsystem, and an eye structure imaging subsystem, wherein the subsystems have a shared optical axis, and each subsystem is operatively coupled to the others via a controller. The eye structure imaging subsystem is preferably a fourierdomain optical coherence tomographer, and more preferably, a swept source OCT.

A method of processing B-scans acquired by an OCT imaging system to generate correction data for compensating for axial displacements between B-scans caused by a variation in distance between the OCT imaging system and an imaging target, and to generate a reliability indicator indicative of a reliability of the correction data. The correction data is generated by determining, for each pair of adjacent B-scans, a respective indicator of an axial shift between respective representations of a common ocular feature in the adjacent B-scans. The reliability indicator is generated by: calculating values indicative of speeds or accelerations of the imaging target relative to the OCT imaging system when pairs of B-scans were acquired; where at least a predetermined number of calculated values exceed a threshold, setting the reliability indictor to indicate that the correction data is unreliable, and otherwise to indicate that the correction data is reliable.

An ophthalmological information processing apparatus includes an acquisition unit and an image correcting unit. The acquisition unit is configured to acquire a front image depicting a predetermined site of a subject's eye in multiple gradations and an OCT image of the subject's eye. The image correcting unit is configured to correct a pixel value in a region including a first position of the predetermined site in the OCT image based on a pixel value at a second position corresponding to the first position in the front image.

The methods and systems provided can automatically determine an Arteriolar-to-Venular diameter Ratio, AVR, in blood vessels, such as retinal blood vessels and other blood vessels in vertebrates. The AVR is an important predictor of increases in the risk for stroke, cerebral atrophy, cognitive decline, and myocardial infarct.

A method is provided for observing structure and function of individual cells in a living human eye, comprising: using an adaptive optics optical coherence tomography (AO-OCT) system to image a volume of a retinal patch including numerous cells of different types, as for example, ganglion cells; using 3D subcellular image registration to correct for eye motion, including digitally dissecting the imaged volume; and using organelle motility inside the cell to increase cell contrast and to measure cell temporal dynamics.

Ophthalmic imaging systems and related methods provide pseudo feedback to aid a user in aligning the user's eye with an optical axis of the imaging system. An ophthalmic imaging system includes an ophthalmic imaging device having an optical axis, a display device, an eye camera, and a control unit. The display device displays a fixation target viewable by the user. The eye camera images the eye to generate eye image data. The control unit processes the eye image data to determine a position of the eye relative to the optical axis, processes the position of the eye relative to the optical axis to generate a pseudo position of the eye relative to the optical axis, and causes the display device to display an indication that provides feedback to the user that the eye is located at the pseudo position of the eye relative to the optical axis.

A wide range within a subject eye is observed while a burden on a subject of whom the subject eye is part is moderated. In an optical system that deals with light reflected from the fundus of the subject eye, a first optical system that pertains to a field of view of a fundus central portion centered on an optical axis is used as a standard optical system. The optical system can be switched by a replacement mechanism from the first optical system to a second optical system that pertains to a field of view of a fundus surroundings portion surrounding the fundus central portion.