Disclosed are systems and methods for generating wide-field optical coherence tomography angiography (OCTA) images. In embodiments, multiple OCTA scans of a sample are automatically acquired at overlapping locations. The systems and methods include functionality to adaptively control the scanning procedure such that eye blink and eye motion events are detected in real time and accounted for during 3D scan acquisition. Also disclosed are methods for detecting and correcting motion-related artifacts in OCTA datasets which allow for the longer scan times over larger fields of view required for wide-field imaging. These methods may include division of en face angiogram images into a set of motion-free parallel strips, and application of gross and fine registration methods to align overlapping strips into a motion- corrected composite image. A series of overlapping motion-corrected composite images may be combined into a larger montage to enable wide-field OCTA imaging using multiple OCTA scans.

An imaging system for cell-based therapies is provided. The imagining system includes one or more optical tags configured for insertion into a cell or biological tissue, an excitation light source configured to illuminate the one or more optical tags; a detector configured to measure optical emission of the one or more optical tags; an imaging subsystem configured to determine a three-dimensional location of each of the one or more optical tags in the cell or biological tissue; and a controller in electrical communication with the excitation light source, the detector, and the imaging subsystem. Each of the one or more optical tags has a contrasting feature and includes a fluorescent material. The contrasting feature may be defined by at least one of a refractive index, shape, color, and laser emission of each optical tag of the one or more optical tags.

The invention relates to a method for determining the occurrence of a vascular collapse of a blood vessel in or on the eye. According to the invention, it is proposed that the vascular collapse be determined from a measured temporal change of blood flow in the blood vessel.

A prism array light redistribution apparatus for an eye imaging system including light transmitting fibers, light receiving fibers, and a micro prism array optically coupled to bridge the light transmitting fibers and the light receiving fibers, configured to receive light having a bell-shaped angular distribution from the light transmitting fibers and refract light emitted by the light transmitting fibers to enter the light receiving fibers

This present disclosure relates to the technical field of artificial intelligence, and provides a vessel image classification method and apparatus, a device, and a storage medium. The method includes: inputting a first vessel image sample into a first image processing model, and obtaining a predicted enhanced image and predicted vessel location information; and training the first image processing model based on a second vessel image sample, vessel location labeling information, the predicted enhanced image, and the predicted vessel location information. In the above solution, the impact of image quality on the vessel classification is considered during training of the vessel classification model, so that an end-to-end vessel classification model subsequently generated based on the trained first image processing model can realize a higher classification accuracy for a low quality vessel image, thereby improving the accuracy of classifying vessels in the vessel image by artificial intelligence.

An ophthalmoscope for examining eyes, includes: a housing; a converting device for converting light into an electrical signal; and an objective, the objective comprising a lens and/or a mirror. The objective has a convexly curved focus area, a convexly curved image surface of an eye being able to be sharply imaged onto the converting device by means of the objective.

Systems and methods for performing a retinal angiogram, which can be used to non-invasively quantify retinal perfusion by measuring differences in retinal vascular density. The systems and methods can be used to measure a response of the vasculature, particularly in the choriocapillaris. The systems and methods can be used to diagnose neurodegenerative conditions, associated sleep and mood disorders, and measure metabolic reserve. In particular, the systems and methods can also be used for both diagnostics and prognostics.

A system and method for use with optical coherence tomography (OCT) data to identify a target pathology extracts multiple pathology-characteristic images from the OCT data. The extracted pathology-characteristic images may include a mixture of OCT structural images (including retinal layer thickness information) and OCT angiography images. Optionally, other pathology-characteristic images and data maps (mapped to corresponding positions in the OCT data), such as fundus images and visual field test maps may be accessed as additional pathology-characteristic images. Each pathology-characteristic image defines a different image channel (e.g., “color channel”) per pixel in a composite, channel-coded image, which is then used to train a neural network to search for the target pathology in OCT data. The trained neural network may then receive new composite, channel-coded image and identify/segment the target pathology within the new channel-coded image.

One embodiment is directed to a system comprising a head-mounted member removably coupleable to the user's head; one or more electromagnetic radiation emitters coupled to the head-mounted member and configured to emit light with at least two different wavelengths toward at least one of the eyes of the user; one or more electromagnetic radiation detectors coupled to the head-mounted member and configured to receive light reflected after encountering at least one blood vessel of the eye; and a controller operatively coupled to the one or more electromagnetic radiation emitters and detectors and configured to cause the one or more electromagnetic radiation emitters to emit pulses of light while also causing the one or more electromagnetic radiation detectors to detect levels of light absorption related to the emitted pulses of light, and to produce an output that is proportional to an oxygen saturation level in the blood vessel.

An image processing method including acquiring a fundus image, extracting a first area including a first feature from the fundus image, extracting a second area including a second feature different from the first feature from the fundus image, and generating a combined image in which the extracted first area and the extracted second area are combined.