Tracer kinetic models are utilized as temporal constraints for highly under-sampled reconstruction of DCE-MRI data. In one embodiment, a method for improving dynamic contrast enhanced imaging. The method includes steps of administering a magnetic resonance contrast agent to a subject and then collecting magnetic resonance contrast agent from the subject. A tracer kinetic model (i.e. eTofts or Patlak) is selected to be applied to the magnetic resonance imaging data. The tracer kinetic model is applied to the magnetic resonance imaging data. Tracer kinetic maps and dynamic images are simultaneously reconstructed and a consistency constraint is applied. The proposed method allows for easy use of different tracer kinetic models in the formulation and estimation of patient-specific arterial input functions jointly with tracer kinetic maps.

A process for profiling fluid distribution and analyzing fluid redistribution kinetics in multi-layer absorbent articles is disclosed.

A method is for providing a medical image of a patient. The method includes acquiring medical measurement data of the patient, including a set of multiple sampled state combinations; a first state space, including first physiological states, and a second state space, including second physiological states, together spanning a third state space. Each of the combinations includes a state from the first and second state spaces, and the third state space includes the set of combinations. The method further includes generating a medical image of the patient using the medical measurement data acquired, including a further state combination; the further state combination including a state from the first and second state space, the third state space including the further state combination, and the further state combination lying within the third state space outside the set of combinations. Finally, the method includes providing the medical image of the patient generated.

The present invention relates to magnetic contrast structures for magnetic resonance imaging, and methods of their use. The contrast structures include magnetic materials arranged as a pair of disk-shaped magnetic components with a space between a circular surface of each disk shape, or a tubular magnetic structure, a substantially cylindrical magnetic structure, a substantially spherical shell-formed magnetic structure, or a substantially ellipsoidal shell-formed structure, each defining a hollow region therein. The space and/or hollow region in the contrast structure creates a spatially extended region contained within a near-field region of the contrast structure over which an applied magnetic field results in a homogeneous field, such that nuclear magnetic moments of a second material when arranged within the spatially extended region precess at a characteristic Larmor frequency, whereby the contrast structure is adapted to emit a characteristic magnetic resonance signal of the magnetic material.

A process for the preparation of beads including a biocompatible hydrophobic polymer, a perfluorocarbon, polyvinylalcohol and optionally a metal compound, including the steps of: adding the perfluorocarbon and optionally the metal compound to a solution of the biocompatible hydrophobic polymer in a polar solvent to provide a first liquid mixture, adding the first liquid mixture to an aqueous solution of a biocompatible surfactant including polyvinylalcohol under sonication to obtain a second liquid mixture, a) maintaining the sonication of the second liquid mixture while cooling, b) evaporating the polar solvent from the second liquid mixture to obtain a suspension of beads including the biocompatible hydrophobic polymer, the perfluorocarbon and optionally the metal compound, c) separating the beads from the suspension and preparing a water suspension of the beads and d) freeze-drying the water suspension to obtain the beads, wherein the addition of the first liquid mixture to the biocompatible surfactant in step b) is performed within a period of at most 10 seconds, wherein the sonication in step b) and the sonication in step c) are performed directly into the liquid mixtures by for example a probe or flow sonicator at an amplitude of at least 120 m for 0.01-10 minutes and wherein the weight ratio of the biocompatible surfactant to the biocompatible hydrophobic polymer is at least 3:1. Beads having close F-H2O interactions, which are suitable for imaging purposes.

In a method and magnetic resonance (MR) system for determining at least one measuring point-in-time in a cardiac cycle for conducting diffusion measurements of the myocardium of an examination object, a sequence of MR images of the heart is acquired and a time curve of a parameter of the cardiac geometry is determined in the sequence of MR images. At least one mean of the parameter of the cardiac geometry is determined from the time curve of the parameter. For the determined at least one mean of the parameter, the associated point-in-time in the time curve of the parameter is determined in which the determined mean occurs, wherein the determined point-in-time defines the at least one measuring point-in-time in a cardiac cycle during which the diffusion measurements of the myocardium are carried out.

A method is for performing an angiographic measurement of a main measurement region of a patient via a magnetic resonance system. An embodiment of the method includes performing at least one overview measurement to generate overview-measurement data; defining, using the overview-measurement data, the main measurement region and a first measurement region, the first measurement region differing from the main measurement region; performing a first time-resolved measurement in the first measurement region defined to generate first time-resolved measurement data; detecting an injected contrast agent bolus in the first measurement region using the first time-resolved measurement data; determining a flow rate of the injected contrast agent bolus detected; setting at least one measurement parameter of the angiographic measurement according to the flow rate determined; and performing the angiographic measurement of the main measurement region of the patient in the magnetic resonance system using the at least one measurement parameter set.

A method for identifying target regions in a tissue for local drug delivery, where functional and/or structural anatomical data such as edema and/or resection cavity is captured by an imaging system, and where the anatomical data is evaluated by segmentation techniques such as region-growing-based methods with computer assistance to determine a margin around a resection cavity and/or the volume of edema, the margin and/or the volume of edema being the target tissue for local drug delivery.

An imaging apparatus for imaging a sample includes a magnetic apparatus that defines a sample volume that is large enough to accommodate the sample to be imaged, and one or more magnetically manipulatable materials within the sample. The magnetic apparatus includes a magnet that is configured to create a magnetic field having a magnitude B in the sample Each magnetically manipulatable material is a material that exhibits a transition between a first magnetic state and a second magnetic state in response to a change in a property associated with the sample while the magnetic field having the magnitude B is maintained in the sample.

An apparatus includes a magnetic apparatus that defines an actuation volume that is large enough to accommodate a sample, the magnetic apparatus including a magnet that is configured to create a magnetic field having a magnitude B in the sample when supplied with a DC current; at least one biological construct within the sample, the biological construct configured to change its status in response to a change in a property; and at least one magnetocaloric actuator coupled with the biological construct. A change in a characteristic in the actuation volume causes the property of the magnetocaloric actuator to change, which causes a change in the status of the biological construct.