A multifunctional ophthalmic instrument and method for assessing ocular surface health is disclosed. The instrument includes an illumination projector, which contains broadband light sources, covering visible and near infrared spectra, a zoom lens system with continuously variable magnification, a detection system to record said images, and a computer to display and analyze said images. Preferably, an eye alignment system with a beamsplitter is used to provide a fixation target for the eye under assessment. An optional thermal camera, operating in the long wave infrared spectrum is aligned paraxially to the zoom lens system. Further, an optional separate video camera is used to monitor the blink rate. Corneal topography and tear break up time could be evaluated with a low magnification, and microscopic features, such as tear meniscus height, meibomian gland orifices, are imaged at a high magnification. Meibomian glands and lipid layer thickness are analyzed with visible and near infrared spectra.

A target surface in an eye is located using a dual aiming beam apparatus that transmits a first aiming beam of light and a second aiming beam of light. An optics subsystem receives a laser beam from a laser source, the first aiming beam of light, and the second aiming beam of light, and directs the beams of light to be incident with the target surface and aligns the beams of light such that they intersect at a point corresponding to a focus of the laser beam. An imaging apparatus captures an image of the target surface including a first spot corresponding to the first aiming beam of light and a second spot corresponding to a second aiming beam of light. A separation between the spots indicates that the focus is away from the target surface, while overlapping spots indicate the focus is at or on the target surface.

An ophthalmic apparatus includes an illumination optical system including a slit in which a slit-shaped aperture is formed and an iris aperture in which two apertures are formed at positions away from an optical axis position, the iris aperture being arranged at a position substantially conjugate optically to an iris of a subject's eye between a light source and the slit, and configured to generate slit-shaped illumination light using light from the light source and to guide the illumination light to a fundus of the subject's eye; and an imaging optical system including an imaging aperture in which an aperture is formed, and configured to guide returning light of the illumination light to an image sensor, the returning light being guided from the fundus by pupil division and passing through the aperture formed in the imaging aperture. A width of the slit-shaped aperture, a distance between the two apertures, and a size of the aperture in the imaging aperture are set so that an overlap region of a light flux region of the illumination light and a light flux region of the returning light is located on a side of the fundus from a posterior surface of lens of the subject's eye within the eye of the subject eye.

In some embodiments, techniques for using machine learning to enable visible light pupilometry are provided. In some embodiments, a smartphone may be used to create a visible light video recording of a pupillary light reflex (PLR). A machine learning model may be used to detect a size of a pupil in the video recording over time, and the size over time may be presented to a clinician. In some embodiments, a system that includes a smartphone and a box that holds the smartphone in a predetermined relationship to a subject's face is provided. In some embodiments, a sequential convolutional neural network architecture is used. In some embodiments, a fully convolutional neural network architecture is used.

In certain embodiments, double-vision-related vision defects determinations or modifications may be facilitated. In some embodiments, a stimulus may be to be presented at a first time at a position on a first display for a deviating eye of a user (e.g., without a stimulus being presented on a second display of for a reference eye of the user) to cause the deviating eye to fixate on the position on the first display. A deviation measurement for the deviating eye may be determined based on an amount of movement of the deviating eye occurring upon the presentation on the first display for the deviating eye at the first time. In some embodiments, a modification profile associated with the user may be determined based on the deviation measurement, where the modification profile includes one or more modification parameters to be applied to modify an image for the user.

A self service refraction instrument includes an adjustable optical assembly coupled within an instrument housing between an eyepiece and a viewing target display. A defocus correcting component includes a pair of adjustably spaced apart spherical lens elements. An astigmatism correcting component includes a pair of cylindrical lens elements that are synchronously rotatable in opposite directions for adjusting cylinder power and in a same direction for adjusting axis angle. A decision module informed by visual acuity scores for an autorefraction Rx or an old prescription Rx of a test subject, the test subject's communicated choices among presented options of corrective optics prescriptions and a refraction rules database that decides to next test sphere, axis or cylinder, at a specific step size of increments, or to test visual acuity, or to end a test.

A fundus imager includes a camera for capturing eye fundus images, and a display for displaying the eye fundus images. The fundus imager captures an eye fundus video using the camera, performs an analysis on the eye fundus video to generate a signal, and calculates one or more vital signs from the signal.

An ophthalmic apparatus includes an objective lens arranged to be passed through by first and second measurement optical axes that are positioned at a distance from each other. An OCT optical system performs OCT on a subject's left eye arranged on the first measurement optical axis or a subject's right eye arranged on the second measurement optical axis. An optical axis adjusting unit adjusts an optical axis of the OCT optical system under control of a controller so that the optical axis approximately coincides with any one of the first measurement optical axis and the second measurement optical axis. An intraocular parameter calculator calculates an intraocular parameter of the subject's left or right eye based on a detection result of interference light acquired in a state where the optical axis of the OCT optical system approximately coincides with the first or second measurement optical axis.

To provide a display apparatus that makes it possible to further improve a performance in controlling video presentation according to characteristics of an eyeball of a user. A display apparatus is provided that includes a light source; a processor that performs processing on a distribution of characteristics of an eyeball; a monitoring section that monitors a state of the eyeball; a matching section that performs matching on the distribution of the characteristics of the eyeball and the state of the eyeball; and an irradiator that irradiates a specified position on a retina with video display light emitted by the light source.

A system to perform remote oculography includes light-occluding goggles configured to be worn by a patient. The light-occluding goggles include an infrared camera positioned to capture one or more first images of a first eye of the patient. The light-occluding goggles also include a display positioned such that it is viewable by a second eye of the patient. The display is configured to display a pattern for the patient to view. The light-occluding goggles also include a sensor configured to detect information regarding a position of a head of the patient. The system also includes a visible light camera configured to capture one or more second images of the patient as the patient wears the light-occluding goggles.