The invention provides novel Compton camera detector designs and systems for enhanced radiographic imaging with integrated detector systems which incorporate Compton and nuclear medicine imaging, PET imaging and x-ray CT imaging capabilities. Compton camera detector designs employ one or more layers of detector modules comprised of edge-on or face-on detectors or a combination of edge-on and face-on detectors which may employ gas, scintillator, semiconductor, low temperature (such as Ge and superconductor) and structured detectors. Detectors may implement tracking capabilities and may operate in a non-coincidence or coincidence detection mode.