Systems and methods to estimate 3D TOF scatter include acquisition of 3D TOF data, determination of 2D TOF data from the first TOF data, determination of first estimated scatter based on the second TOF data, reconstruction of a first estimated image based on the first estimated scatter and the second TOF data, determination of attenuated unscattered true coincidences based on the first estimated image, determination of second estimated scatter based on the first TOF data and the attenuated unscattered true coincidences, and reconstruction of an image of the object based on the first TOF data and the second estimated scatter.

Systems and methods to estimated mean randoms include acquisition of list mode data describing true coincidences and delay coincidences detected by a positron emission tomography scanner during a scan of an object, determination, for each crystal of the positron emission tomography scanner and for each of a plurality of time periods of the scan, of delay coincidences including the crystal based on the list mode data, determination, each crystal, of determine a singles rate associated with each time period based on the delay coincidences determined for the crystal over the time period, determination, for each time period, of determine estimated mean randoms for each of a plurality of pairs of the crystals based on the singles rate associated with the time period for each crystal of the crystal pair, and reconstruction of an image of the object based on the estimated mean randoms for each time period and the detected true coincidences.

One embodiment provides a method for three-dimensional imaging by determining distances of objects within scenes, the method including: emitting a light onto an object within a scene for a predetermined length of time; receiving a plurality of reflections of the light from the object, wherein each of the plurality of reflections is received for a predetermined length of time less than an exposure time for a frame of the scene, wherein the photon detector generates an electrical signal; determining depth location information of at least a portion of the object within the scene corresponding to the given of the electrical signals; and generating, from the depth location information of portions of the object within the scene, a three-dimensional image for the frame of the scene.

A signal sampling method comprising: sampling an electrical signal to be measured using a pre-determined sampling method to obtain a plurality of first sampling points, each of which is represented by a first amplitude and a corresponding first time; measuring a second amplitude of the electrical signal to be measured, wherein the second amplitude is different from the plurality of the first amplitudes; and delaying the electrical signal to be measured, and using the delayed electrical signal to determine a second time when the amplitude of the electrical signal to be measured reaches the second amplitude in order to obtain a second sampling point, which is represented by the second amplitude and the second time. A greater number of sampling points can be sampled, such that the precision of sampling and also the accuracy of subsequent signal restoration may be improved.

An x-ray tomography system which can generate a qualitative 3D image of a region of interest using a an x-ray source, the x-ray source configured to emit x-ray radiation at the region of interest. The x-ray radiation or the x-ray source or the relative position of the x ray source configured to be moved in a two dimensional plane. An x-ray detector including a plurality of detector elements arranged in a two dimensional plane opposite the x-ray source, the x-ray detector configured to detect x-ray radiation after attenuation by the subject and provide an indication of the detected x-rays. And a processor configured to receive the indication of the detected x-rays and resolve the detected x-ray radiation into a three dimensional image. The three dimensional image is qualitative in nature.

Multiple interactions, such as Compton scattering, inside a PET detector are used to predict an incident photon's direction for identifying true coincidence events versus scatter/random coincidence events by creating a cone shaped shell projection defining a range of possible flight directions for the incident photon. The disclosed techniques can be used as prior information to improve the image reconstruction process. The disclosed techniques can be implemented in a LYSO/SiPM-based layer stacked detector, which can precisely register multiple interactions' 3D position.

The disclosure relates to a device and positron emission tomography (PET) scanner for acquiring a PET image and a system for generating the PET image. The disclosure describes a device that may have one or more moveable portions. The device may comprise an upper portion and a lower portion. The upper portion and lower portion define a cavity for a patient. At least one of the upper portion or the lower potion may be movable. The upper and lower portions may comprise a cap and wings, respectively, At least one of the caps and/or wings may comprise one or more detection modules. The wings may also move with respect to a corresponding cap.

A nuclear medicine diagnostic apparatus according to a present embodiment includes a plurality of units of detector that detects gamma rays, and each of the units of detector includes detection circuitry, generation circuitry, and first production circuitry. The detection circuitry detects an analog signal based on a result of detecting the gamma rays. The generation circuitry generates a clock signal. The first production circuitry produces time information by converting the analog signal into a digital signal on the basis of the clock signal.

The present disclosure may provide a SPECT system. The SPECT system may include a collimator including a group of first pinholes and a group of second pinholes. The group of first pinholes may be configured to remain open. The group of second pinholes may be configured to alternate between an open configuration and a blocked configuration. The collimator may be configured to allow photons to traverse through at least one group of the group of first pinholes or the group of second pinholes. The SPECT system may also include a detector configured to detect at least a portion of the photons that have traversed the collimator.

An anti-scatter collimator is for arrangement in a stacked construction with an X-ray detector. In an embodiment, the anti-scatter collimator includes collimator walls arranged adjacently at least along a first direction. The collimator walls are mutually spaced to provide a through-channel between each pair of adjacent collimator walls. The through-channels provided by the arrangement of the multiplicity of collimator walls are at least partially filled with a filler material.