A garment cuff protection device for preventing soiling of cuffs includes a panel that is flexible. A coupler is coupled to a first face of the panel and is configured to removably couple the panel to an interior surface of a cuff of a sleeve of a garment. The panel is configured to prevent soiling of the cuff.

A garment is provided that includes an outer tubular garment portion and an inner tubular garment portion that are each fabricated from the same, continuous piece of protective material. By being formed from continuous portion of material, a user is provided with protection from ingress of fluids around an appendage when such fluid might be otherwise introduced through breaks in the material that rely entirely on a circumferential seam to secure separate pieces of material together. The inner tubular portion is not removable or severable from the outer tubular garment portion but is extendible to allow a user flexibility of use (e.g., stretching) without sacrificing performance. A method of creating a circumferentially continuous fluid impervious seal is also provided.

A cuff attachment for an isolator sleeve cuff, the cuff attachment comprising an annular band of substantially elastomeric material having an open first end and an open second end, the first end having a diameter which is wider than a diameter of the second end, the first end being adapted to be attachable to an isolator sleeve cuff, and the second end being adapted to releasably retain a plug therein. A plug for sealing the second end of the cuff attachment, the plug comprising a body sized and shaped to be releasably retained in the second end of the cuff attachment. An isolator sleeve system comprising the cuff attachment and the plug.

A cuff attachment for an isolator sleeve cuff, the cuff attachment comprising an annular band of substantially elastomeric material having an open first end and an open second end, the first end having a diameter which is wider than a diameter of the second end, the first end being adapted to be attachable to an isolator sleeve cuff, and the second end being adapted to releasably retain a plug therein. A plug for sealing the second end of the cuff attachment, the plug comprising a body sized and shaped to be releasably retained in the second end of the cuff attachment. An isolator sleeve system comprising the cuff attachment and the plug.