The present disclosure relates to contact lenses for use with eyes experiencing eye-length related disorders, like myopia with or without astigmatism. This invention relates to a contact lens for managing myopia with or without astigmatism; wherein the contact lens is configured with an optical zone defined substantially centred about its optical axis to provide a meridionally and azimuthally variant power distribution resulting, at least in part, in a foveal correction of the myopic eye and, at least in part, resulting in a conoid of partial blur at the retina of the myopic eye, serving as a directional cue or an optical stop signal; and a non-optical peripheral carrier zone about the optical zone configured with a invariant azimuthal thickness distribution, with or without rotation assisting features, to further provide temporally and spatially varying stop signals to decelerate, control, inhibit, or reduce the rate of myopia progression substantially consistent over time.

A microfluidic flow restrictor that uses micron-sized beads to impede flow is described. The flow rate can be adjusted by adding or removing the beads using injection needles through self-sealing ports, one injection needle injecting or aspirating beads and another injection needle pushing or pulling fluid from outside of a bead trap within the flow restrictor. In alternative embodiments, the beads or other filler material can be trapped in a manifold bead trap such that they block a subset of fluid channels of the flow restrictor, allowing fluid to flow freely through the rest of the fluid channels. The flow restrictor can be integrated with a contact lens or implantable medical device for use in dispensing liquid therapeutic agents at flow rates of microliters per minute or moving body fluids at a controlled rate from one part of the body to another.

The present invention relates to a system for corneal crosslinking of injured corneas, treating keratoconus, or correcting vision, the system comprising: a hyaluronic acid-dye conjugate; and a contact lens including an LED light source.

In the present invention, a dye is activated by receiving light irradiated from the LED light source of the contact lens so as to generate radicals, thereby generating a covalent bond between amino acid radicals of corneal collagen, and strengthening a collagen layer. In the present invention, the hyaluronic acid-dye conjugate, in which hyaluronic acid is bound to the dye, is used to improve penetration of the dye in the cornea, and the contact lens is used together with the hyaluronic acid-dye conjugate to further improve the penetration of the dye. In addition, the structure of the lens which presses the center of the cornea deforms the shape of the cornea, thereby having a vision correction effect.

A contact lens having more than one configuration is disclosed herein. The optical power of the contact lens may be dynamically changed through the different configurations of the contact lens. The different configurations may be actuated using a valve. Also disclosed herein is a contact lens comprising a dimension, which contact lens is configured to have the dimension change non-linearly as a function of a pressure applied to the contact lens.

Disclosed are lenses and methods for verifying a lens with an induced aperture. The lenses can have a geometry that, among other things, maintains a centered position about a wearer's eye to prevent more than a permissible amount of movement of the lens relative to the eye. Further disclosed is a method for verifying the power profiles used with the lens, and a lens that can have a single power profile for a wide range of presbyopia.

Contact lenses that have an ion-impermeable portion and an ion-permeable portion that are able to move on the eye without binding to the eye are described. The contact lenses exhibit an average ionoflux transmittance of at least 1.34×10.sup.−4 mm/min. One or more electronic components can be included in the contact lenses. Methods of making the contact lenses are also described.

The invention relates to a method for producing embedded hydrogel contact lenses involving a set of 3-mold halves consisting essentially of: one female lens mold half having a molding surface defining the anterior surface of a contact lens; one male lens mold half having a molding surface defining the posterior surface of the contact lens; and an insert mold half having a molding surface defining one of the front and back surfaces of an insert. One of the lens mold halves is used twice: first with the insert mold half for molding an insert during first curing process and then with the other lens mold half for molding an embedded hydrogel contact lens with the molded insert embedded partially or fully therein during second curing process. The invention also relates to embedded hydrogel contact lenses produced from a method of the invention.

The invention is directed to an embedded hydrogel contact lens, which comprises an insert sandwiched between two layers of hydrogel materials and can be produced according to a cast molding method including the procedures involving two females halves (FC1 and FC2) and two male halves (BC1 and BC2) and three consequential molding steps involving three molding assemblies: the 1st one formed between FC1 and BC1 for molding an insert; the 2.sup.nd one formed between FC1 and BC2 for molding a lens precursor having the molded insert embedded in a layer of a hydrogel material in a way that the front surface of the molded insert merges with the convex surface of the lens precursor; and the 3rd one formed between FC2 and BC2 for molding an embedded hydrogel contact of the invention.

Embodiments concern an optical eye-contact device comprising a lens body having a symmetry axis and which further comprises a light-transmissive portion and an opaque portion, wherein the light-transmissive portion is decentered with respect to the symmetry axis.

The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a watersoluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, to and at a temperature from about 40° C. to about 140° C. for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.