An ultra high-resolution near infrared brain imager system includes a modular cap housing closely spaced multiple vertical-cavity surface-emitting laser-single-photon avalanche photodiode array (VCSEL-SPAD) modules, each one of the VCSEL-SPAD modules including a linear VCSEL array and a SPAD detector.

Provided is a holographic microscope including an input optical system configured to emit polarized input beam, a first beam splitter configured to emit an object beam by reflecting a portion of the polarized input beam, and emit a reference beam by transmitting a remaining portion of the polarized input beam, a reference optical system configured to separate the reference beam into a first reference beam and a second reference beam, a camera configured to receive the first reference beam and the second reference beam and the object beam that is reflected by an inspection object, the camera including a micro polarizer array, wherein a first polarization axis of the first reference beam is perpendicular to a second polarization axis of the second reference beam.

A method of structured illumination digital holography includes: (a) providing a structured illumination generating unit and binarization random number encoding unit to generate a coded structured illumination pattern; (b) sampling at least two patterns with phase shift which synthesized as a single structured illumination pattern to be encoded; (c) forming a single digital hologram, and wavefront reconstructing the single digital hologram; (d) performing a compressive sensing approach to recover the object wave with at least two phase shift patterns; and (e) reconstructing the separation of overlap spectrum, to obtain an image covering bandpass spectrum with different high frequency and low frequency.

The present invention can realize both a transmission type and a reflection type, and provides a holographic microscope which can exceed the resolution of the conventional optical microscope, a hologram data acquisition method for a high-resolution image, and a high-resolution hologram image reconstruction method. In-line spherical wave reference light (L) is recorded in a hologram (I.sub.LR) using spherical wave reference light (R), and an object light (O.sup.j) and an illumination light (Q.sup.j) are recorded in a hologram (I.sup.j.sub.OQR) using a spherical wave reference light (R) by illuminating the object with an illumination light (Q.sup.j, j=1, . . . , N) which is changed its incident direction. From those holograms, a hologram (J.sup.j.sub.OQL), from which the component of the reference light (R) is removed, is generated, and from the hologram, a light wave (h.sup.j) is generated. A light wave (c.sup.j) of the illumination light (Q.sup.j) is separated from the light wave (h.sup.j), and using its phase component (.sup.j=c.sup.j/|c.sup.j|), a phase adjustment reconstruction light wave is derived and added up as (H.sub.P=h.sup.j/.sup.j), and an object image (S.sub.P=|H.sub.P|.sup.2) is reconstructed.

A system for motility contrast imaging a biological target within tissue comprising a CCD array; an illumination source for generating an incoming beam; a first beam splitter for receiving the incoming beam and producing an object beam and a reference beam; a second beam splitter for illuminating a multitude of biological targets with the object beam and for directing backscattered object beams towards the CCD array; a computer-controlled delay stage for zero-path-matching the reference beam to the backscattered object beams; a reference beam that intersects the backscattered object beams at an angle to produce a series of interference fringes that modulate Fourier-domain information; and a computer for receiving a time series of Fourier-domain information. The interference fringes between the backscattered object beam and the reference beam are recorded by the CCD array and passed to the computer which constructs a digital hologram at successive times.

In some implementations, a method comprises: determining a set of characteristics of light spectra reflected or transmitted by a set of materials when the set of materials is illuminated by a plurality of light wavelengths; constructing one or more classifiers configured to classify each material of the set of materials based on the set of characteristics of the light spectra; using the classifiers, mapping each of the light spectra onto an area of an image sensor; wherein one or more optical elements filter and focus the light spectra onto one or more elements of a detector array; wherein each optical element focuses onto an area of the detector array; wherein the mapping is a 1:1 mapping; wherein each optical element uses a Bragg reflection condition to filter the light spectra and to focus the light spectra onto an element of the detector array.

A method for digital holographic microtomography comprises (a) providing at least one wavefront controlling device for driving a sample to be rotated and/or an incident beam scanning the sample, (b) utilizing a digital holographic access unit for recording the transmitted or reflected wavefronts of the sample, (c) utilizing a digital holography reconstructing method for reconstructing the transmitted or reflected wavefronts of the sample, and (d) utilizing a tomographic reconstruction approach for reconstructing three dimensional image information of the sample.

The invention relates to an interferometric method, in which the light scattered by an object is imaged onto an electronic camera, wherein a sample light component is assigned to scattering sites on a sectional face in the interior of the object. This sample light component can he separated from the contributions of the other sample light components by processing of the camera image and leads to a sectional image. A particular advantage of the invention lies in the fact that multiple parallel sectional faces can be exposed sequentially at predetermined intervals from each other in the interior of the object. Such a sequence of sectional images can be used to calculate a solid model of the object.

The invention is applicable in particular to the live retina and allows a three-dimensional retina scan within a few seconds with a cost-effective and, if necessary, hand-held device.

Application options are in the fields of ophthalmology and in biometry.

A lens-less digital holographic microscope, a reflective digital holographic microscope, and a digital holographic microscope including a plurality of lenses. In one example, the digital holographic microscope includes a single mode fiber collimated light source which provides illumination for both the science and reference arms, a pair of microscope objectives located side-by side, and illuminated by the common beam, a relay lens whose center is between the two objectives, and a focal plane element where the interference pattern is measured.

Laser 3D imaging techniques include splitting a laser temporally-modulated waveform of bandwidth B and duration D from a laser source into a reference beam and a target beam and directing the target beam onto a target. First data is collected, which indicates amplitude and phase of light relative to the reference beam received at each of a plurality of different times during a duration D at each optical detector of an array of one or more optical detectors perpendicular to the target beam. Steps are repeated for multiple sampling conditions, and the first data for the multiple sampling conditions are synthesized to form one or more synthesized sets. A 3D Fourier transform of each synthesized set forms a digital model of the target for each synthesized set with a down-range resolution based on the bandwidth B.