Source light having a range of optical wavelengths is generated. The source light is split into sample light and reference light. The sample light is delivered into a sample, such that the sample light is scattered by the sample, resulting in signal light that exits the sample. The signal light and the reference light are combined into an interference light pattern having optical modes, each having a direct current (DC) component and at least one alternating current (AC) component. Different subsets of the optical modes of the interference light pattern are respectively detected, and analog signals representative of the optical modes of the interference light pattern are output. Pair of the analog signals are subtracted from each other, and differential analog signals are output. The sample is analyzed based on the differential analog signals.

A method and user device for determining a unified Parkinson's disease rating scale (UPDRS) value associated with a user of the user device include obtaining video data associated with a movement of a body part of the user. The UPDRS value is determined using a model and the video data associated with the movement of the body part of the user. The UPDRS value is provided to permit an evaluation of the user based on the UPDRS value.

A system for monitoring the cardiopulmonary functioning of a person includes a remote terminal and a sensor module configured to be worn by the person. The sensor module includes at least one physiological sensor configured to sense the following types of physiological information generated by the person: pulse rate, blood flow, and blood pressure; at least one signal processor configured to process signals generated by the at least one physiological sensor; and at least one transmitter responsive to the at least one signal processor that is configured to transmit at least one signal to the at least one remote terminal. The at least one signal processor is configured to focus processing resources on one of the types of physiological information in response to a specified preference by the person.

A system includes an eye tracker having a camera, the eye tracker being configured and arranged to track an eye movement of a subject, and a processor in communication with the eye tracker, the processor being configured and arranged to create a dataset of the eye movement, generate a plot of the dataset, the plot reflecting a timecourse of eye position versus time, and identify one or more streaking vertical lines in the plot to indicate a deficit in cranial nerve II function.

Wearable apparatus for monitoring various physiological and environmental factors are provided. Real-time, noninvasive health and environmental monitors include a plurality of compact sensors integrated within small, low-profile devices, such as earpiece modules. Physiological and environmental data is collected and wirelessly transmitted into a wireless network, where the data is stored and/or processed.

An earpiece monitor configured to be worn by a subject includes a battery, an earpiece fitting configured to be inserted within an ear canal of an ear of the subject, a reflective pulse oximeter configured to measure pulse rate and pulse intensity of the subject, a motion sensor configured to monitor footsteps and head motion of the subject, a digital memory for storing at least one algorithm, and a processor configured to process signals from the reflective pulse oximeter and the motion sensor using the at least one algorithm to generate as assessment of a health state of the subject. The earpiece fitting is configured to transmit sound to the inner ear or eardrum of the subject. The assessment of the health state of the subject may include an assessment of subject physiological stress and/or an assessment of overall subject health.

Systems and methods for path length selected diffuse correlation spectroscopy (PLS-DCS) are disclosed. The systems and methods are suitable for measuring dynamics of a target medium. The systems and methods can utilize light sources having a coherence length that is shorter than a path length distribution of the target medium and can utilize a reference optical path to interferometrically detect PLS-DCS signals. The coherence length and reference path length can be selected to provide sensitivity to portions of the target medium that correspond to a desired path length distribution.

Systems and methods are provided for determining an acceleration at a location of interest within one of a user's head and neck. At least one of linear acceleration data, angular acceleration data, angular velocity data, and orientation data is produced using at least one sensing device substantially rigidly attached to an ambient-accessible surface of the user's head. The location of interest is represented relative to a position of the at least one sensing device as a time-varying function. An acceleration at the location of interest is calculated as a function of the data produced at the sensing device and the time-varying function representing the location of interest. The calculated acceleration at the location of interest is provided to at least one of the user and an observer in a human-perceptible form.

Devices, systems and methods are disclosed that allow a patient to self-treat neurodegenerative diseases, such as dementia, Alzheimer's disease, ischemic stroke, post-concussion syndrome, chronic traumatic encephalopathy and the like by electrical noninvasive stimulation of a vagus nerve. The system comprises a handheld stimulator that is applied to the surface of the patient's neck, wherein the stimulator comprises or is joined to a smartphone. A camera of the smartphone may be used to position and reposition the stimulator to a particular location on the patient's neck. The system may also comprise a base station that is used to meter the charging of a rechargeable battery within the stimulator. The base station and stimulator transmit data to one another regarding the status of a stimulation session.

According to various embodiments, there is provided a method for determining a neurological condition of a subject using a robotic system. The robotic system includes a transducer. The method includes determining, by a computing system, a first location with respect to a vessel of the subject, the robotic system configured to position the transducer at the first location. The method further includes receiving, by the computing system, a first signal from the vessel in response to the transducer transmitting acoustic energy towards the vessel. The method further includes analyzing, by the computing system, the received first signal to determine a first parameter of blood flow in the vessel. The method further includes determining, by the computing system, the neurological condition of the subject based on the first parameter of the blood flow in the vessel.