A method of analysis using mass spectrometry and/or ion mobility spectrometry is disclosed comprising: (a) using a first device to generate smoke, aerosol or vapour from a target in vitro or ex vivo cell population; (b) mass analysing and/or ion mobility analysing said smoke, aerosol or vapour, or ions derived therefrom, in order to obtain spectrometric data; and (c) analysing said spectrometric data in order to identify and/or characterise said target cell population or one or more cells and/or compounds present in said target cell population.

A sensor network, which includes a sensor controller serially coupled to a plurality of sensor modules, is configured to program the sensor modules so as to transfer measurement data to the sensor controller and to synchronize the sensor modules to picosecond accuracy via on-chip or on-module custom circuits and a physical layer protocol. The sensor network has applications for use in PET, LiDAR or FLIM applications. Synchronization, within picosecond accuracy, is achieved through use of a picosecond time digitization circuit. Specifically, the picosecond time digitization circuit is used to measure on-chip delays with high accuracy and precision. The delay measurements are directly comparable between separate chips even with voltage and temperature variations between chips.

The disclosure herein relates to systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking. In some embodiments, the systems, devices, and methods described herein are configured to analyze non-invasive medical images of a subject to automatically and/or dynamically identify one or more features, such as plaque and vessels, and/or derive one or more quantified plaque parameters, such as radiodensity, radiodensity composition, volume, radiodensity heterogeneity, geometry, location, perform computational fluid dynamics analysis, facilitate assessment of risk of heart disease and coronary artery disease, enhance drug development, determine a CAD risk factor goal, provide atherosclerosis and vascular morphology characterization, and determine indication of myocardial risk, and/or the like. In some embodiments, the systems, devices, and methods described herein are further configured to generate one or more assessments of plaque-based diseases from raw medical images using one or more of the identified features and/or quantified parameters.

The disclosure relates to a system and method for medical imaging. The method may include: move, by a motion controller, a phantom along an axis of a scanner to a plurality of phantom positions; acquire, by a scanner of the imaging device, a first set of PET data relating to the phantom at the plurality of phantom positions; and store the first set of PET data as an electrical file. The length of an axis of the phantom may be shorter than the length of an axis of the scanner, and at least one of the plurality of phantom positions may be inside a bore of the scanner.

The present disclosure relates to a method, system and non-transitory computer readable medium. In some embodiments, the method includes: acquiring image data of a target subject positioned on a scanning table of an imaging device; determining, by a processor, first position information of the target subject by inputting the image data into a first machine learning model, the first position information of the target subject including a posture of the target subject relative to the imaging device; determining, by the processor, second position information related to a scan region of the target subject by inputting the image data into a second machine learning model, the second position information including a position of the scan region relative to the scanning table and the imaging device; and causing the imaging device to scan the target subject based on the first position information and the second position information.

An MR-PET apparatus is provided. The MR-PET apparatus may include a supporting component, a PET detection device, an RF coil, and a signal shielding component. The PET detection device may be supported on the supporting component. The PET detection device may be configured to receive a plurality of photons. The RF coil may be configured to generate or receive a radio frequency (RF) signal. The signal shielding component may be placed between the PET detection device and the RF coil. The signal shielding component may be configured to shield the PET detection device from at least part of the RF signal.

The present disclosure provides a system and method for motion field generation and image correction. The method may include obtaining a plurality of first sets of magnetic resonance (MR) image data of an object generated based on a plurality of first sets of imaging sequences. The method may include obtaining a motion curve of the object. The method may include obtaining position emission tomography (PET) image data of the object generated in a scanning time period. The method may include generating one or more target motion fields corresponding to the scanning time period based on the plurality of first sets of MR image data and the motion curve. The method may include generating one or more corrected PET images by correcting, based on the one or more target motion fields, the PET image data.

A method and apparatuses for a radiation detector apparatus, comprising a scintillator array comprising a plurality of scintillator crystals. The plurality of scintillator crystals includes a first scintillator crystal and a second scintillator crystal adjacent to the first scintillator crystal within the scintillator array. A photosensor array comprising a plurality of photosensors including a first photosensor configured to detect photons from the first scintillator crystal. A first separator positioned between the first scintillator crystal and the second scintillator crystal. First separator optically separates the first scintillator crystal and the second scintillator crystal such that the first photosensor detects photons from the first scintillator crystal and not from the second scintillator crystal.

The disclosure relates to PET imaging systems and methods. The systems may obtain a plurality of PET images of a subject and a CT image acquired by performing a spiral CT scan on the subject. Each gated PET image may include a plurality of sub-gated PET images. The CT image may include a plurality of sub-CT images each of which corresponds to one of the plurality of sub-gated PET images. The systems may determine a target motion vector field between a target physiological phase and a physiological phase of the CT image based on the plurality of sub-gated PET images and the plurality of sub-CT images. The systems may reconstruct an attenuation corrected PET image corresponding to the target physiological phase based on the target motion vector field, the CT image, and PET data used for the plurality of gated PET images reconstruction.

The invention refers to an apparatus that allows to improve the image quality of nuclear images, e.g. PET images. The apparatus (110) comprises a providing unit (111) for providing nuclear image data of a region of interest, a providing unit (112) for providing a motion signal indicative of a motion of the region of interest, a determination unit (113) for determining different motion states of the region of interest based on the motion signal, a determination unit (114) for determining for each motion state nuclear image data corresponding to the motion state, a reconstruction unit (115) for reconstructing an absorption map for each motion state based on the corresponding nuclear image data of the respective motion state, and a reconstruction unit (116) for reconstructing one or more nuclear images of the region of interest based on the nuclear image data and the absorption maps reconstructed for each motion state.