A Compton camera for medical imaging is divided into segments with each segment including part of the scatter detector, part of the catcher detector, and part of the electronics. The different segments may be positioned together to form the Compton camera arcing around part of the patient space. By using segments, any number of segments may be used to fit with a multi-modality imaging system.

Peptides that home, target, migrate to, are directed to, are retained by, or accumulate in and/or bind to the cartilage or kidney of a subject are disclosed. Pharmaceutical compositions and uses for peptides or peptide-active agent complexes comprising such peptides are also disclosed. Such compositions can be formulated for targeted delivery of an active agent to a target region, tissue, structure or cell in the cartilage. Targeted compositions of the disclosure can deliver peptide or peptide-active agent complexes to target regions, tissues, structures, or cells targeted by the peptide.

With a diagnostic imaging support apparatus, a diagnostic imaging support method, and a diagnostic imaging support program, an optimum image for extracting a contour can be automatically selected from a superimposed image obtained by superimposing a plurality of images of different types. A diagnostic imaging support apparatus 1 includes: an accepting unit 22 that accepts a specification of the position of a predetermined defined region R on a superimposed image G obtained by superimposing a plurality of images of different types including a target image G0 that is a target on which a contour is created; a selection unit 23 that selects an image for extracting a contour on the basis of image information about regions R0, R1, and R2, in the plurality of images of different types, each corresponding to the accepted defined region R; and a contour extraction unit 24 that extracts the contour from the selected image.

Systems, instruments, and methods for surgical navigation with verification feedback are provided. The systems, instruments, and methods may be used to verify a trajectory of a surgical tool during a procedure. The systems, instruments, and methods may receive one or more captured images of an anatomical portion of a patient; execute a surgical plan to insert the surgical tool into the anatomical portion; receive sensor data collected from one or more sensors being inserted into the anatomical portion; determine whether the sensor data corresponds to the surgical plan; and send, in response to determining that the sensor data does not correspond to the surgical plan, an alert indicating that the surgical tool is not being inserted according to the surgical plan. The one or more sensors may be attached to the surgical tool.

Various aspects include methods compensating for Compton scattering effects in pixel radiation detectors. Various aspects may include determining whether gamma ray detection events occurred in two or more detector pixels within an event frame, determining whether the gamma ray detection events occurred in detector pixels within a threshold distance of each other in response to determining that gamma ray detection events occurred in two or more detector pixels within the event frame, and recording the two or more gamma ray detection events as a single gamma ray detection event having an energy equal to the sum of measured energies of the two or more gamma ray detection events located in a detector pixel having a highest measured energy in response to determining that the gamma ray detection events occurred in detector pixels within the threshold distance of each other.

An operating device for a medical system for imaging and/or intervention is disclosed. In an embodiment, the operating device includes a housing; a grip region; a coupling unit; and a connecting unit. The connecting unit is configured to releasably connect to a holding structure for the operating device and, via the coupling unit, is coupled to the grip region such that a releasing of a releasable connection is caused by a gripping of the grip region with one hand of a person and an establishing of the releasable connection is caused by a letting go of the grip region. Further, the grip region is configured for carrying of the operating device by a gripping the grip region with one hand of the person.

A framework for quality-driven image processing. In accordance with one aspect, image data and anatomical data of a region of interest are received. Zonal information is generated based on the anatomical data. Image processing is performed based on the image data to generate an intermediate image. One or more image quality metrics may then be determined for the intermediate image data using the zonal information. A processing action may be performed based on the one or more image quality metrics to generate a final image.

A method for performing a computer-aided diagnosis (CAD) includes: acquiring a medical image set; generating a three-dimensional (3D) tumor distance map corresponding to the medical image set, each voxel of the tumor distance map representing a distance from the voxel to a nearest boundary of a primary tumor present in the medical image set; and performing neural-network processing of the medical image set to generate a predicted probability map to predict presence and locations of oncology significant lymph nodes (OSLNs) in the medical image set, wherein voxels in the medical image set are stratified and processed according to the tumor distance map.

A vestibular neurostimulation device, which may include first and second electrodes; first and second thermoelectric devices thermally coupled, respectively, to first and second earpieces that are configured to be insertable into respective ear canals of a patient; and a controller comprising a waveform generator. The waveform generator may be is configured to deliver a modulated electric signal to the patient through galvanic vestibular stimulation (GVS) using the first and second electrodes and to deliver a time varying thermal waveform to the patient through caloric vestibular stimulation (CVS) using the first and second earpieces simultaneous with the delivery of the modulated electrical signal through GVS. The CVS and/or GVS may be configured to increase a passage of insulin-like growth factor 1 (IGF-1) through a blood-brain-barrier.

A medical imaging system for detecting ionizing radiation. The system includes one or more pixilated imagers positioned to acquire patient image data and one or more position sensors positioned to acquire patient position data. Once the patient image data and patient position data are acquired, one or more processors operably connected to each of the one or more pixilated imagers and one or more position sensors calculate a three-dimensional mass distribution based on patient image data and patient position data.