A computer-implemented system and method for generating a medical image is provided. In some embodiments, the medical image is generated by determining a location and an alignment for a first tracking detector with respect to a particle beam system. The direction of a beam generated from the particle beam system is determined. A first position of a first particle from a detected particle hit on the first tracking detector is also determined. A determination is made as to a first residual range of the first particle from a detected particle hit on a residual range detector. The system reconstructs a path for the first particle based on the location, the alignment, the first position, and the first residual range of the first particle. The resulting medical image that is generated by the system is based on the reconstructed path for the first particle.

An imaging system utilizes 2D DXA images obtained in a tomographic imaging process or mode in order to provide more detailed information to the operator of the bone structure of the patient. The imaging system obtains multiple 2D DXA images at different angles with regard to the patient in a number of passes across the body of the patient. These 2D DXA images can then be utilized to reconstruct at least one 2D slice of the body of the patient, such as in a plane parallel to the plane of a patient support surface, such as a scanner table. The information provided by the tomographic reconstruction provides enhancements to the process of modifying a 3D FEA model associated to an already available set of tomographic reconstructed slices selected from the comparison with the current tomographic reconstructed slices. In this manner, the system and method provide a significant reduction in the error of the resulting modified 3D FEA model for review and analysis compared to a 2D approach.

An x-ray imaging system utilizes enhanced computing arrays. A plurality of x-ray illumination source positions are utilized to produce x-ray radiation at each of the x-ray illumination source positions and to project x-ray radiation towards an object. A detector detects x-ray radiation from the object and transmits detector images for each of the illumination source positions. A memory buffer stores the detector images from the detector. A graphics processing unit formats the detector images and constructs a complete frame data set with the detector images for each of the illumination source positions. Another graphics processing unit receives the complete frame data set and performs image reconstruction on the complete frame data set.

A proton radiography system includes a source of a proton beam at nonrelativistic energy, directed on a beam path to an object to be imaged; one or more time-of-flight (TOF) detectors arranged on the beam path to detect incidence of beam protons and generate output signals indicative thereof with a time resolution substantially less than a time of flight of the protons; and a data acquisition and analysis subsystem coupled to the TOF detectors to receive the respective output signals and (1) calculate TOF values for respective bunches of one or more protons, (2) convert the TOF values to proton velocity values and proton energy values, and (3) use the proton energy values to calculate a corresponding value for a physical property of the object along the beam path, and incorporate the value into elements of a radiographic image of the object stored or displayed in the system.

Methods of two-dimensional x-ray imaging of a target volume and tracking a target structure contained within a target volume are described.

The disclosure provides improvements of resolution and contrast in the field of x-ray imaging by using a line emitting, quasi-monochromatic x-ray source for x-ray fluorescence computed tomography. A particular type of x-ray source suitable for this is a line emitting liquid-jet-anode x-ray source. X-ray fluorescence is obtained using nanoparticles, preferably coated nanoparticles with a metallic core. The x-ray radiation from the x-ray source is shaped and filtered using energy dispersive optics before being delivered to the nanoparticles.

Tracking a target structure contained within a target volume using an x-ray tomosynthesis imaging detector is described.

An IGRT system and methods are described embodiments of which perform selectively integration of x-ray source arrays, dual-energy imaging, stereoscopic imaging, static and source collimation, or inverse geometry tomosynthesis imaging to acquire or track a target during radiation treatment.

Methods of two-dimensional x-ray imaging of a target volume and tracking a target structure contained within a target volume are described.

Tracking a target structure contained within a target volume using an x-ray tomosynthesis imaging detector is described.